Adverse drug effect
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Determination of drug-related problems in the hematology service: A prospective interventional study
Patients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects.
8p vishanshan 27-06-2024 2 1 Download
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Recent advances in the management of pancreatic neuroendocrine tumors (pNETs) highlight the potential benefits of temozolomide, an alkylating agent, for these patients. In this meta-analysis, we aimed to assess the outcome of temozolomide, alone or in combination with other anticancer medications in patients with advanced pNET.
15p vikoch 27-06-2024 1 1 Download
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This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.
467p vimeyers 29-05-2024 4 2 Download
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Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.
15p vioraclene 31-03-2024 5 1 Download
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Available anti-ulcer drugs unveil partial effectiveness and numerous adverse reactions. The present study investigated the possible protective effect of the herbal formulation Vien Khoi Tim (VKT) on indomethacininduced gastric mucosal damage in rats.
9p vilarry 12-03-2024 3 2 Download
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Part 2 book "Toxicological effects of veterinary medicinal products in humans (Vol 2)" includes content: Human safety of veterinary vaccines, adverse drug reactions in humans – data from veterinary pharmacovigilance schemes, veterinary medicines and the environment, potential adverse microbiological effects of antimicrobials.
199p muasambanhan02 18-12-2023 7 1 Download
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People with drug-resistant epilepsy (DRE) are at high risk of sudden unexpected deaths and lower quality of life. Experiments showed thread embedding acupuncture (TEA) has a seizurereducing effect; however, data on DRE has been limited. This trial aimed to establish the efficacy and safety of TEA in people with DRE.
9p vikissinger 21-12-2023 2 2 Download
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Several studies have reported an association between severe neutropenia and long-term survival in patients treated with trifuridine-tipiracil (TAS-102). Because some of these studies failed to address immortality time bias, however, their findings should be interpreted with caution.
8p vileonardodavinci 23-12-2023 3 2 Download
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Continued part 1, part 2 of ebook "Veterinary pharmacovigilance: Adverse reactions to veterinary medicinal products" provides readers with content including: safety assessment of veterinary vaccines; microbiological assessment of veterinary medicinal products and potential adverse effects; adverse effects of veterinary pharmaceutical products in animals; adverse drug reactions in dogs – toxic hepatic responses; adverse reactions to vaccines;...
405p lytamnguyet 04-08-2023 7 2 Download
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The study aimed to investigate the needs for DI service and evaluate the effectiveness of the enhanced DI service at Pham Ngoc Thach (PNT) hospital. HCPs at PNT hospital completed the first survey on the demand for DI in June 2022 and the second survey on the effectiveness of the DI service in April 2023.
14p viwolverine 11-07-2023 5 2 Download
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Antibiotics administered incorrectly may result in detrimental consequences, such as prolonging treatment duration, causing adverse effects, or even increasing mortality. The research aimed to examine the characteristics of the antibiotics list utilized at PDHC in 2019.
7p viwarmachine 03-07-2023 3 2 Download
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As the US Food and Drug Administration (FDA) receives over a million adverse event reports associated with medication use every year, a system is needed to aid FDA safety evaluators in identifying reports most likely to demonstrate causal relationships to the suspect medications. We combined text mining with machine learning to construct and evaluate such a system to identify medication-related adverse event reports.
8p visteverogers 24-06-2023 4 3 Download
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The Food & Drug Administration (FDA) is considering the permanent exemption of premarket notification requirements for several Class I and II medical device products, including several artificial Intelligence (AI)– driven devices. The exemption is based on the need to rapidly more quickly disseminate devices to the public, estimated cost-savings, a lack of documented adverse events reported to the FDA’s database.
3p vighostrider 25-05-2023 2 2 Download
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Identification of drugs, associated medication entities, and interactions among them are crucial to prevent unwanted effects of drug therapy, known as adverse drug events. This article describes our participation to the n2c2 shared-task in extracting relations between medication-related entities in electronic health records.
8p vighostrider 25-05-2023 5 2 Download
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Muscarinic agonists are indicated for the treatment of many conditions including ileus, urinary retention, glaucoma, and Sjögren’s syndrome. Due to their lack of tissue specificity, these drugs can lead to undesirable side effects at of-target sites and may be potentiated by supplements that impact the half-life of these drugs.
4p vigamora 23-05-2023 3 2 Download
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Methotrexate is an anticancer drug from the antimetabolite class. It is also used in gynecology and obstetrics for the medical treatment of ectopic pregnancies. Low-dose methotrexate-induced adverse toxic effects are rare. We report a case of toxic effect associated with severe renal insufficiency induced by LD-MTX (Low-Dose Methotrexate) for ectopic pregnancy.
6p vidoctorstrange 06-05-2023 5 2 Download
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RAD140 (Testalone) is a novel selective androgen receptor modulator with very limited data currently available on adverse effects related to this compound. The first-in-human phase 1 trial was recently published and did report a significant proportion of elevated aspartate aminotransferase, alanine transaminase, and total bilirubin among the test subjects.
3p vidoctorstrange 06-05-2023 5 2 Download
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Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population
Several pathogenesis and genetic factors influence predisposition to antituberculosis drug-induced hepatotoxicity (ATDH) especially for isoniazid (INH). However, the major susceptibility genes for ATDH are N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1).
6p vinarcissa 21-03-2023 6 1 Download
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Vaginal administration is a promising route for the local treatment of infectious vaginal diseases since it can bypass the first-pass metabolism, drug interactions, and adverse effects. However, the commercial products currently available for topical vulvovaginal treatment have low acceptability and do not adequately explore this route.
11p viginny 30-12-2022 5 2 Download
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Diabetes is a group of diseases characterized by high levels of blood sugar for an extended period. Despite newer and effective therapy, current treatment is riddled with fundamental challenges. To overcome the adverse effects of existing drugs, regenerative medicine has emerged as an essential treatment, for which tissue engineering may serve as a foundation for the repair of pancreatic cells secreting insulin.
13p viporsche 28-10-2022 8 2 Download