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Aetiological risk factors
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Early identification of genetic risk factors for complex diseases can enable timely interventions and prevent serious outcomes, including mortality. While the genetics underlying many Mendelian diseases have been elucidated, it is harder to predict risk for complex diseases arising from the combined effects of many genetic variants with smaller individual effects on disease aetiology.
13p
vicwell
29-02-2024
5
2
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Cancer of Unknown Primary (CUP) is metastatic cancer with an unidentifiable primary tumour origin during life. It remains difficult to study the occurrence and aetiology of CUP. Hitherto, it is unclear whether risk factors are associated with CUP, yet identifying these factors could reveal whether CUP is a specific entity or a cluster of metastasised cancers from various primary tumour origins.
13p
vischultz
20-10-2023
6
1
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High-risk human papillomavirus (HR-HPV) is the main aetiological factor for the development of cervical cancer. While nearly 70% of HR-HPV infections are cleared within 12 months, in the remainder of women they persist and can progress into cervical cancer.
6p
vipriyankagandhi
27-07-2022
3
1
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Musculoskeletal disorders are common worldwide. Several factors are suggested in their aetiology, one of which is ergonomics alongside other individual factors. This study aims at investigating the prevalence of musculoskeletal disorders among administrative office workers at a large university in Saudi Arabia.
9p
vimackenziebezos
30-11-2021
7
2
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Musculoskeletal disorders are the most frequent occupational diseases in Europe. However, their multifactorial aetiology poses several challenges concerning not only the estimation of relative prevalence rates across occupational groups but also how the co-occurrence of known risk factors might differ between disorders of the upper and lower limbs.
11p
viannito2711
20-04-2021
11
1
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Females have a two-fold risk of developing knee osteoarthritis (OA) as compared to their male counterparts and atypical walking gait biomechanics are also considered a factor in the aetiology of knee OA.
12p
vioregon2711
22-02-2021
12
2
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Temporary hemiepiphysiodesis (TH) using an eight-Plate implant is one of the most common surgeries used for the correction of coronal angular deformities around the knee in adolescents. However, few studies have focused on children aged less than 10 years treated with TH using an eight-Plate implant.
11p
vivermont2711
28-01-2021
6
2
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The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the overall skeletal status and turnover in patients with BMES, with the aim of identifying risk factors for this disease.
9p
vivermont2711
28-01-2021
13
1
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Hip pain is prevalent in children with cerebral palsy (CP). Hip displacement is a known risk factor for hip pain. However, many children do not have displaced hips but still have hip pain and the aetiologies are poorly understood.
10p
vivermont2711
28-01-2021
6
2
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This is a retrospective observational study of 157 patients diagnosed with lower-extremity CVI that underwent surgical treatment at Department of Thoracic and Vascular Surgery, Medicine and Pharmacy Hospital from 08/2004 to 08/2006.
4p
angicungduoc9
05-01-2021
9
2
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The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France. Methods: We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case–control study, the ICARE study.
10p
vijennie2711
29-09-2020
11
0
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The aetiology of urological cancers is poorly understood and variations in incidence by ethnic group may provide insights into the relative importance of genetic and environmental risk factors. Our objective was to compare the incidence of four urological cancers (kidney, bladder, prostate and testicular) among six ‘non-White’ ethnic groups in England (Indian, Pakistani, Bangladeshi, Black African, Black Caribbean and Chinese) to each other and to Whites.
12p
vimoscow2711
29-08-2020
9
1
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Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen.
18p
vibaku2711
22-07-2020
10
2
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Findings of population-age subgroup variations in LC mortality and the number of underdiagnosed cases can inform surveillance efforts, while more extensive investigations of the aetiological risk factors are needed. Impact: There was a large race, sex and age differences in trends of LC mortality in SA.
9p
vimanila2711
29-06-2020
7
0
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Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a simple substitute for inherited susceptibility.
17p
vikuala271
13-06-2020
7
1
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The aetiology of disabling chronic conditions in childhood in high income countries is not fully understood, particularly the association with socio-economic status (SES). Very few studies have used longitudinal datasets to examine whether exposure to social disadvantage in early childhood increases the risk of developing chronic conditions in later childhood.
7p
vivalanbo2711
19-03-2020
8
2
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Delia-Marina Alexe MD PhD is a graduate of the University of Medicine and Pharmacy “Carol Davila” in Bucharest, Romania. She trained in trauma and cancer epidemiology at the University of Athens Medical School, Greece. She joined the Non-communicable Disease Epidemiology Unit at the London School of Hygiene and Tropical Medicine, UK, in 2006. Her research interests include cancer aetiology and trends; the role of adipose tissue hormones and growth factors in cancer risk; and early life environment and cancer risk....
0p
khongmuonnghe
07-01-2013
46
2
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There will be cases where chemical interferences can be identified for a particular method but the chances of encountering them in real life may be improbable. The analyst has to decide at what point it is reasonable to stop looking for interferences. These parameters apply to both qualitative and quantitative analysis. The selectivity of a method is usually investigated by studying its ability to measure the analyte of interest in test portions to which specific interferences have been deliberately introduced (those thought likely to be present in samples).
246p
kmkmkmkmkm
06-09-2012
45
3
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