Affective disorders
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Clinical and genetic characteristics of children with Alagille syndrome in Children’s Hospital No. 1
Alagille syndrome is an autosomal dominant disorder that affects many various organs. Objectives: Determining the prevalence of clinical and genetic characteristics of children with Alagille syndrome in Children’s Hospital No.1.
7p viwalton 29-06-2024 1 1 Download
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Obstructive Sleep Apnea is a prevalent disorder that affects individuals across various age groups and lifestyles. Although OSA is commonly associated with obesity and sedentary lifestyles, it can also affect physically active individuals. Bodybuilding and obstructive sleep apnea should be interconnected due to factors such as changes in body composition and weight fluctuations.
6p vikoch 27-06-2024 3 1 Download
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Smoking is a major risk factor for multiple gastrointestinal cancers, and adversely affects peptic ulcer disease, gastroesophageal reflux, pancreatitis and Crohn’s disease. Despite key recommendations for diagnosing and treating tobacco use disorder in healthcare settings, the degree to which this is implemented in Gastroenterology (GI) clinics is unknown.
10p vishanshan 27-06-2024 1 1 Download
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Death anxiety is thought to cause a range of mental disorders among cancer patients, which may affect their mental health and even quality of life. This study sought to investigate experiential avoidance, meaning in life, and death anxiety among Chinese cancer patients and then explore the relationship between these 3 variables.
9p vikoch 27-06-2024 2 1 Download
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Esophageal squamous cell carcinoma (ESCC) is a high-risk malignant tumor that has been reported in China. Some studies indicate that gut microbiota disorders can affect the occurrence and development of ESCC, but the underlying mechanism remains unclear. In this study, we aimed to explore the possible underlying mechanisms using microbiomics and metabolomics.
17p vikoch 27-06-2024 4 1 Download
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Topical Reviews in Neurosurgery, Volume 1 focuses on neurosurgery, a medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders that affect any portion of the nervous system. This book discusses the advances in computed tomography, vascular surgery in neurological disorders, and carotid endarterectomy.
196p vimeyers 29-05-2024 5 2 Download
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Oxidoreductases (ORases) are enzymes that catalyze oxidation and reduction reactions in cells or extracellular compartments of the body. Genetic mutations and other factors that affect ORase activity have been implicated in a range of diseases, especially inherited metabolic disorders. Aldose reductase, sorbitol dehydrogenase, xanthine oxidoreductase are the ORases with relevance to diabetes pathology.
7p dianmotminh02 03-05-2024 3 1 Download
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Part 2 book "A textbook of opthalmology" includes content: Ocular diseases and ocular affections in systemic diseases - urgical procedures, miscellaneous aspects, genetics and paediatric ophthalmology, immunology related to ocular disorders, prevention and rehabilitation of blindness.
363p zizaybay1101 30-04-2024 6 3 Download
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Autistic individuals are commonly characterized by stereotypical behaviors, which affect their daily life, particularly social aspects. The study aimed to assess the effectiveness of dance movement-based intervention in reducing stereotypical behavior among autistic children.
9p viarnault 25-04-2024 3 2 Download
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Recent studies have used genome-wide data to investigate evolutionary mechanisms related to behavioral phenotypes, identifying widespread signals of positive selection. Here, we conducted a genome-wide investigation to study whether the molecular mechanisms involved in these traits were affected by local adaptation.
12p vibransone 28-03-2024 2 2 Download
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Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism.
14p vibransone 28-03-2024 5 2 Download
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Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown.
15p vibransone 28-03-2024 5 2 Download
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Germline chromothripsis causes complex genomic rearrangements that are likely to affect multiple genes and their regulatory contexts. The contribution of individual rearrangements and affected genes to the phenotypes of patients with complex germline genomic rearrangements is generally unknown.
14p vioraclene 31-03-2024 2 2 Download
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Recent studies have suggested that individual variants do not sufficiently explain the variable expressivity of phenotypes observed in complex disorders. For example, the 16p12.1 deletion is associated with developmental delay and neuropsychiatric features in affected individuals, but is inherited in > 90% of cases from a mildly-affected parent.
21p vibransone 28-03-2024 8 2 Download
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Age and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue function. However, the underlying cellular and genetic factors linking aging and obesity on adipose tissue function have remained elusive.
24p vicwell 29-02-2024 4 2 Download
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Part 2 book "Ebersole and Hess’ gerontological nursing and healthy aging" includes content: Living with chronic illness, diseases affecting vision and hearing, metabolic disorders, bone and joint problems, cardiovascular and respiratory disorders, cognitive impairment, mental health, economic and legal issues, definitions of elder abuse and neglect,... and other contents.
214p muasambanhan08 23-02-2024 2 1 Download
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Glycogen storage disease type IX is a rare disorder that can cause a wide variety of symptoms depending on the specific deficiency of the phosphorylase kinase enzyme and the organs it affects.
6p vitiki 30-01-2024 5 2 Download
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Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder and the fourth cause of death of end-stage renal disease. The disease has a prevalence of 1:400–1:1000 accounting for 10% of patients on dialysis. In most ADPKD patients, bilateral kidneys are similarly affected, with numerous fluid-filled cysts arising from different nephron segments.
4p vitiki 30-01-2024 7 2 Download
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Transverse myelitis is a rare neurological disorder of the spinal cord, caused by inflammation and damage of the myelin sheath of the neurons of the spinal cord across one or more spinal segments. This causes a disruption in the passage of nervous signals leading to motor, sensory, and autonomic dysfunction. This affects the physical and psychological health, as well as the functional status of the patient.
9p vitiki 30-01-2024 7 2 Download
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Wolfram syndrome is a rare autosomal recessive neurodegenerative disorder that affects 1/200,000 to 1/1,000,000 children. It is characterized by juvenile onset diabetes, optic nerve atrophy and other systemic manifestations. Symptoms of the disease arise mostly in early childhood with a high mortality rate due to severe neurological complications.
5p vitiki 30-01-2024 7 2 Download