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Alkylating agent
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Recent advances in the management of pancreatic neuroendocrine tumors (pNETs) highlight the potential benefits of temozolomide, an alkylating agent, for these patients. In this meta-analysis, we aimed to assess the outcome of temozolomide, alone or in combination with other anticancer medications in patients with advanced pNET.
15p
vikoch
27-06-2024
1
1
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In this paper, we report a simple and fast method to produce uniform nano-sized Ag particles that can be dispersed in the oil phase by using oleic acid as solvent and capping agent. Oleylamine, a longchain amine that can act as an electron donor at elevated temperatures and is miscible with oleic acid, was selected as a reductant.
6p
viambani
18-06-2024
1
1
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The genetic origins of chemotherapy resistance are well established; however, the role of epigenetics in drug resistance is less well understood. To investigate mechanisms of drug resistance, we performed systematic genetic, epigenetic, and transcriptomic analyses of an alkylating agent-sensitive murine lymphoma cell line and a series of resistant lines derived by drug dose escalation.
11p
vioraclene
31-03-2024
2
1
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Fluorinated carboxylic acids have been in use as ion-pairing reagents for over three decades. It has been observed that ion-pairing reagents not only increase the retention of oppositely charged analytes on reversed-phase HPLC columns but also decrease the retention of similarly charged analytes.
8p
viginny
23-12-2022
8
3
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High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears to have a radiosensitizing effect when used in combination with RT and may be worthwhile in meningioma treatment.
6p
vikolindagrabar
27-07-2022
6
2
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The Urea-Hydrogen Peroxide complex (UHP) was synthesized from urea and hydrogen peroxide, characterized by FT-IR. This UHP complex could be employed as an oxidizing agent for metal-free oxidation reaction of disulfides to thiosulfinate compounds. This protocol was carried out under very mild conditions at 0oC in CH3CO2H solvent, was efficient and compatible with a range of alkyl, aryl or allyl disulfides to afford direct access to thiosulfinate compounds in very good yields up to 92% and high selectivities.
8p
cothumenhmong11
05-05-2021
12
1
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Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy. TMZ is an alkylating agent that induces autophagy, apoptosis and senescence in GBM cells.
13p
vijisoo2711
29-09-2020
9
0
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Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is a highly effective alkylating agent which causes many types of DNA lesions, including DNA base alkylation damage that is repaired by base excision repair (BER).
11p
vijennie2711
25-09-2020
14
1
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Melphalan has been used in the treatment of various hematologic malignancies for almost 60 years. Today it is part of standard therapy for multiple myeloma and also as part of myeloablative regimens in association with autologous allogenic stem cell transplantation. Melflufen (melphalan flufenamide ethyl ester, previously called J1) is an optimized derivative of melphalan providing targeted delivery of active metabolites to cells expressing aminopeptidases.
9p
vinaypyidaw2711
26-08-2020
25
2
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To date, standardized strategies for the treatment of recurrent glioma are lacking. Chemotherapy with the alkylating agent BCNU (1,3-bis (2-chloroethyl)-1-nitroso-urea) is a therapeutic option even though its efficacy and safety, particularly the risk of pulmonary fibrosis, remains controversial.
11p
vinaypyidaw2711
26-08-2020
16
1
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Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we evaluated the EM rate, and investigated the risk factors associated with EM in MM patients.
9p
vimale2711
25-08-2020
13
1
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The metabolic inhibitor 3-bromopyruvate (3-BrPA) is a promising anti-cancer alkylating agent, shown to inhibit growth of some colorectal carcinoma with KRAS mutation. Recently, we demonstrated increased resistance to 3-BrPA in wt p53 tumor cells compared to those with p53 silencing or mutation.
16p
vimale2711
25-08-2020
7
2
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Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors.
10p
viputrajaya2711
22-06-2020
15
0
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A systematic and comparative study on mutagenic ability of different doses of ethyl methane sulphonate (EMS, an alkylating agent), gamma rays (an ionizing radiation) and EMS + gamma rays was carried out in a well-adapted desi chickpea variety HPG17. All mutagenic treatments were effective in inducing genetic variability. A proportional decrease in germination of mutagen treated seeds as well as subsequent plant survival was observed with increase in mutagen dose.
7p
angicungduoc5
14-06-2020
9
0
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The antimutagenic effect of ascorbic acid (vitamin C) was investigated by using the Drosophila wing spot test. In this assay, 3-day-old transheterozygous larvae for the multiple wing hair (mwh, 3-0.3) and flare (flr, 3-38.8) genes were treated with 3 direct acting mutagens: ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS) and N-nitroso N-ethylurea (ENU).
6p
vitamix
15-02-2019
10
0
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From the 3-acetylaminoindan-1-one obtained during the course of our work, we studied the synthesis of novel indanone derivatives as new antitumor agents, by acidic hydrolysis of the acetamide group, diazotisation and alkylation of the amino group and bromination of the cyclopentanic methylene group.
3p
uocvong04
24-09-2015
40
3
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The benzoacronycine derivative, S23906-1, was character-ized recently as a novel potent antitumor agent through alkylation of theN2 positionof guanines inDNA.We show here that its reactivity towards DNA can be modulated by glutathione (GSH). The formation of covalent adducts between GSH and S23906-1 was evidenced by EI-MS, and the use of different GSH derivatives, amino acids and dipeptides revealed that the cysteine thiol group is absolutely required for complex formation because glutathione disul-fide (GSSG) and other S-blocked derivatives failed to react covalently with S23906-1. ...
12p
fptmusic
16-04-2013
38
2
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While researching this book, I came across a letter in the journal Nature asking for caution in the current trend for the use of humorous nomenclature for newly discovered genes1, the author referring to the tumour suppressor gene Pokemon, which I have briefly described in Chapter 4.
349p
hyperion75
18-01-2013
44
5
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A young woman confronted with a diagnosis of systemic lupus erythematosus (SLE) can expect lifelong complications arising from the disease itself, as well as the therapies used to treat this condition. About 50–70 per cent of SLE patients experience inflammation of the kidneys. As such, the young woman can expect to be treated with high doses of corticosteroids, often accompanied by the alkylating agent cyclophosphamide.
758p
hyperion75
18-01-2013
58
6
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis
11p
panasonic06
25-12-2011
40
2
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