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Alpha complex
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McCune–Albright syndrome is a complex disorder encompassing multiple endocrinopathies. These manifestations are secondary to a mutation in the stimulatory G-protein alpha subunit. Cushing syndrome is due to autonomous secretory function of the adrenal gland and is present in 7.1% of patients with McCune–Albright syndrome.
5p
vigamora
23-05-2023
7
2
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In continuation of our interest in identifying new α-glucosidase inhibitors with potential to become antidiabetic drugs, this work focuses on the study of 4-(dimethylaminoalkyl)piperazine-1-carbodithioate derivatives as α-glucosidase inhibitors. The eight heterocyclic piperazine-dithiocarbamate complexes studied in this work contain a variety of substitutions on their benzene ring exhibiting potent, noncompetitive inhibition of α-glucosidase.
9p
lyhuyenthu
31-01-2023
9
2
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N-acetyltransferase 13 (NAT13) is a probable catalytic component of the ARD1A-NARG1 complex possessing alpha (N-terminal) acetyltransferase activity. Results: In this study, a full-length complementary DNA (cDNA) encoding Schistosoma japonicum NAT13 (SjNAT13) was isolated from schistosome cDNAs. The 621bp open reading frame of SjNAT13 encodes a polypeptide of 206 amino acids.
11p
vidarwin
22-02-2022
16
1
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The heterogeneous subtypes and stages of epithelial ovarian cancer (EOC) differ in their biological features, invasiveness, and response to chemotherapy, but the transcriptional regulators causing their differences remain nebulous.
18p
vimahuateng
26-11-2021
8
1
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Hypothyroidism is a common complex endocrinopathy that typically has an autoimmune etiology, and it affects both humans and dogs. Genetic and environmental factors are both known to play important roles in the disease development. In this study, we sought to identify the genetic risk factors potentially involved in the susceptibility to the disease in the high-risk Giant Schnauzer dog breed.
16p
vijeeni2711
24-07-2021
12
0
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Dupuytren’s disease (DD) is a complex fibro-proliferative disorder of the hand that is often progressive and eventually can cause contractures of the affected fingers. Transforming growth factor beta (TGF-β1) has been implicated as a key stimulator of myofibroblast activity and fascial contraction in DD.
12p
vitennessee2711
02-02-2021
9
2
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Understanding channel structures that lead to active sites or traverse the molecule is important in the study of molecular functions such as ion, ligand, and small molecule transport. Efficient methods for extracting, storing, and analyzing protein channels are required to support such studies.
19p
vikentucky2711
24-11-2020
10
2
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Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex has been identified for a subset of these “wild type” GISTs.
9p
vimoscow2711
29-08-2020
9
0
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Mammalian target of rapamycin (mTOR) represents a key downstream intermediate for a myriad of oncogenic receptor tyrosine kinases. In the case of the insulin-like growth factor (IGF) pathway, the mTOR complex (mTORC1) mediates IGF-1 receptor (IGF-1R)-induced estrogen receptor alpha (ERα) phosphorylation/activation and leads to increased proliferation and growth in breast cancer cells.
11p
vimale2711
25-08-2020
13
2
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Although the pathogenesis of paediatric-onset autoimmune hepatitis (pAIH) remains incompletely understood, genetic variants and environmental factors are known to be involved. Caspase recruitment domain family member 10 (CARD10) is a scaffold protein that participates in a complex pathway activating nuclear factor kappa-B (NFjB) and tumour necrosis factor alpha (TNF-a). This study aimed to investigate the association of CARD10 rs6000782 (g.37928186A > C) and TNF gene promoter rs1799724 (c.-1037C > T) variants with pAIH susceptibility in a cohort of Egyptian children.
8p
trinhthamhodang1
14-11-2019
40
2
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The new method uses a continuous-slowing-down model coupled with (a,n) cross section data to precompute the expected neutron yield over the alpha particle lifetime. This eliminates the complexity and computational cost associated with explicit charged particle transport. When combined with an integrated alpha particle decay source sampling capability.
12p
minhxaminhyeu4
26-06-2019
9
0
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Chapter 21 (part 2) - Transcriptional regulation and RNA processing. After completing this chapter, students will be able to: Know the functions of the beta, beta’ and alpha subunits; know the function of the sigma factor and how it affects the binding of the RNA polymerase complex to the promoter; know what concensus sequences are; know the names of the two major concensus sequences associated with the ER. Coli promoter region (-35 region and the Pribnow box (-10 region);....
32p
tangtuy02
08-03-2016
48
3
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GToligomers, showingadose-dependent cytotoxic effect on a variety of human cancer cell lines, but not on normal human lymphocytes, recognize and form complexes with nuclear proteins.By working with human T-lymphoblastic CCRF-CEM cells and by using MS and SouthWestern blotting, we identified eukaryotic elongation factor 1 alpha (eEF1A) as the main nuclear protein that specifically recognizes these oligonucleotides.Western blotting and supershift assays confirmed the nature of this protein and its involvement in forming a cytotoxicity-related complex (CRC)....
12p
tumor12
20-04-2013
34
1
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p38 Mitogen-activated protein kinase alpha (p38 MAPKa) is a member of the MAPK family. It is activated by cellular stresses and has a number of cellular substrates whose coordinated regulation mediates inflammatory responses. In addition, it is a useful anti-inflammatory drug target that has a high specificity for Ser-Pro or Thr-Pro motifs in proteins and contains a number of transcription factors as well as protein kinases in its catalog of known substrates.
15p
fptmusic
11-04-2013
40
1
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RNA polymerase II (pol II) produces all mRNA in eukaryotic cells. Structures of the ten-subunit core of yeast pol II in free form [1, 2], in complex with DNA and RNA [3], and in complex with alpha-amanitin [4] have elucidated the mRNA transcription mech-anism [reviewed in 5, 6]. Based on this work, models for the com-plete 12-subunit pol II were obtained [7, 8]. We have subsequently solved the first structure of pol II in complex with a transcription factor, the elongation factor TFIIS [9, 10].
25p
fptmusic
11-04-2013
32
3
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Previous results have shown that the human oncoembryonic proteina-feto-protein (AFP) induces dose-dependent targeting apoptosis in tumor cells, accompanied by cytochromecrelease and caspase 3 activation. AFP posi-tively regulates cytochrome c⁄dATP-mediated apoptosome complex forma-tion in a cell-free system, stimulates release of the active caspases 9 and 3 and displaces cIAP-2 from the apoptosome and from its complex with recombinant caspases 3 and 9 [Semenkova et al. (2003) Eur. J. Biochem.
13p
inspiron33
25-03-2013
36
3
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As with every hypothesis test, inference based on alpha estimates can lead to the detection of a lucky fund, namely a fund with a significant estimated alpha, while its true alpha is equal to zero. The difficulty raised by the standard approach is that it implies a multiple hypothesis test since the null hypothesis of no performance is not tested once, but M times. Accounting for the presence of luck in a multiple testing framework is much more complex, because luck cannot be measured by the significance level applied to each fund.
83p
dangsuynghi
15-03-2013
66
7
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The ubiquitination and subsequent degradation of stress-induced abnormal proteins are indispensable to cell survival. We previously showed that a yeast (Saccharomyces cerevisiae) mutant carrying a single amino acid change, Ala401Glu, in RSP5, which encodes an essential E3 ubiquitin ligase, is hypersensitive to various stresses.
11p
vinaphone15
25-02-2013
35
1
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The complexes formed by partially folded human and bovine a-lactalbumin with oleic acid (OA) have been reported to display selective apoptotic activity against tumor cells. These complexes were named human (HAMLET) or bovine (BAMLET) alpha-lactalbumin made lethal to tumor cells.
15p
mobifone23
18-01-2013
45
4
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Summary. Turbulence is a complex phenomenon, characterized by many interacting degrees of spatial and temporal freedom. It is widespread, and indeed nearly the rule, in the flow of classical fluids. The complexity of the underlying equations has impeded analytical progress and therefore direct numerical simulations of the equations, as well as experimental work, are key to making further progress. Here, special attention is given to the role of low temperature helium as a test fluid, including the superfluid phase which also exhibits turbulence....
337p
tom_123
14-11-2012
46
6
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