Altered connective

Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity.

23p vibransone 28-03-2024 6 2   Download

DNA methylation plays a key role in development, contributes to genome stability, and may also respond to external factors supporting adaptation and evolution. To connect different types of stimuli with particular biological processes, identifying genome regions with altered 5-methylcytosine distribution at a genome-wide scale is important.

9p vinarcissa 21-03-2023 4 1   Download

Cell division and death play an important role in embryonic development. Cell specialization is accompanied with slow proliferation and quiescence. Cell death is important for morphogenesis. Gene expression changes during differentiation is coordinated by lineage-specific transcription factors and chromatin factors. It is not yet fully understood how alterations in gene expression and cell cycle/death mechanisms are connected. We previously identified a chromatin protein Arid4b as a critical factor for meso/ endoderm differentiation of mouse embryonic stem cells (mESCs).

9p thiencuuchu 27-11-2021 10 1   Download

Chapter 8 - The cellular basis of reproduction and inheritance. The main contents of this chapter include all of the following: Cell division and reproduction, the eukaryotic cell cycle and mitosis, meiosis and crossing over, alterations of chromosome number and structure.

117p tradaviahe14 27-01-2021 9 1   Download

Bioelectrical signals are known to be involved in the generation of cell and tissue polarity as well as in cytoskeletal dynamics. The epithelium of Drosophila ovarian follicles is a suitable model system for studying connections between electrochemical gradients, patterns of cytoskeletal elements and axial polarity.

12p viwyoming2711 16-12-2020 17 1   Download

Human disease often arises as a consequence of alterations in a set of associated genes rather than alterations to a set of unassociated individual genes. Most previous microarray-based meta-analyses identified disease-associated genes or biomarkers independent of genetic interactions.

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Methods for inference and comparison of biological networks are emerging as powerful tools for the identification of groups of tightly connected genes whose activity may be altered during disease progression or due to chemical perturbations.

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Gene expression connectivity mapping has gained much popularity in recent years with a number of successful applications in biomedical research testifying its utility and promise. A major application of connectivity mapping is the identification of small molecule compounds capable of inhibiting a disease state.

16p viconnecticut2711 29-10-2020 9 1   Download

Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA copy number, in connection with tumour dissemination and recurrence in patients with colon cancer.

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The expression alterations of B4GALT1 have been noted in some types of cancer and they are related to cancer cell proliferation, invasiveness, metastasis, and drug resistance. We aimed to establish the expression of B4GALT1 in bladder cancer and its connection to patient outcomes, as well as forecasting the advantages of adjuvant chemotherapy (ACT) in patients with muscle-invasive bladder cancer (MIBC).

9p vibaku2711 22-07-2020 18 2   Download

Autoimmune diseases occur in 3–5% of the population as a result of myriad of genetic and environmental factors that lead to altered immune reactivity. The alterations in the immune system initiated by a loss of immunological tolerance to self-antigens lead to the development of autoreactive phenomena that can be detected in the peripheral blood. The present study was undertaken to detect the Extractable Nuclear Antibodies present in the study population. This study was conducted for a period of 1 year in 100 patients attending Rheumatology department.

6p quenchua4 06-04-2020 16 2   Download

This study aimed to determine the effect of different ozone concentrations applied with different exposure times on the chemical composition and the surface morphology of enamel. Twenty human mandibular molars were divided into four groups according to ozone concentration and exposure times. Group A received 90 lg of ozone/ml oxygen for 1 min, group B received 90 lg of ozone/ml oxygen for 2 min, group C received 120 lg of ozone/ml oxygen for 1 min and group D received 120 lg of ozone/ml oxygen for 2 min.

6p kethamoi1 20-11-2019 21 0   Download

World is changing day by day in every aspect of life. A Smart City is an answer to different challenges such as socio-economic development and quality of life. In the way intelligent technology has brought enormous changes in urban development by altering the relation of production, consumption and distribution, it is now bringing enormous changes to the education sector. By providing technological opportunities for various ways of communication, the relationship between instructors and students has improved.

10p kequaidan1 05-11-2019 20 0   Download

Chapter 8 - The cellular basis of reproduction and inheritance. The main contents of this chapter include all of the following: Cell division and reproduction, the eukaryotic cell cycle and mitosis, meiosis and crossing over, alterations of chromosome number and structure.

129p shiwo_ding2 03-04-2019 22 1   Download

Characterization of animal genetic resources for food and agriculture (AnGR) involves three types of information: phenotypic, genetic and historical. The weight given to each depends on the country (e.g. whether it is developed or developing) and the objective (e.g. improve- ment, conservation or breed differentiation). These guidelines focus on the collection and use of phenotypic information.

158p conduongdinhmenh 07-05-2013 103 8   Download

Work with the hand in Auto IK mode and by directly rotating it until it looks something like the earlier illustration. Now, take a look at the Action Editor. It has several rows, or channels, and each has a name that corresponds to a bone in the active armature. When you select a bone in the 3D view, the corresponding channel in the Action Editor is selected. Just the same, RMB clicking a channel name in the Action Editor selects that bone in the 3D view. In the illustration, the lower_arm.l channel is selected.

8p seketnoi 29-04-2013 40 5   Download

A wide range of poultry products are traded and are aggregated in the model into two distinct categories: high-value and low-value products. The high-value poultry product includes white meat (breasts and wings) of chicken and turkey along with de- boned meat and specialty items. Low-value poultry is comprised of mainly dark meat (drumsticks and thighs) of chicken and turkey. 3 White and dark meats are produced in essentially equal and fixed amounts per bird and are thus treated as jointly produced goods in the model.

29p loginnhanh 22-04-2013 66 2   Download

UhpC is a membrane-bound sensor protein inEscherichia colirequired for recognizing external glucose-6-phosphate (Glc6P) and induction of the transport protein UhpT. Recently, it was shown that UhpC is also able to transport Glc6P.In this studywe investigatedwhether these transport and sensing activities are obligatorily coupled in UhpC.We expressed a His-UhpC protein in a UhpC-deficientE. coli strain and verified that this construct does not alter the basic biochemical properties of the Glc6Psensor system....

8p tumor12 20-04-2013 56 1   Download

One way to avoid that problem is to look at sub-national jurisdic- tions. For example, the 50 U.S. states have much less variation in reli- gion and culture than do two nations such as the United States and China. In 2002, the Fraser Institute produced its first edition of the Economic Freedom of North America, which provided an index of economic freedom in U.S. states and Canadian provinces (see Karabegoviç and McMahon 2008).

20p trinhcaidat 19-04-2013 63 3   Download

However, those runners who have the patience to develop speed for shorter distances will realise even greater benefits when they decide to take the step up the marathon. Building speed before endurance is always the best method of enhancing long-term performance. This article will give you a taste of speed training as it includes an eight-week training program designed to develop your running so you can complete a 10k race in your desired time. The program assumes a basic level of fitness, allowing you to complete the first week relatively comfortably.

15p nhacsihuytuan 06-04-2013 69 5   Download