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Ancestry estimations
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Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. The objective of this study was to construct an African ancestry-specific PrCa PRS (PRState) and evaluate its performance.
11p
vileonardodavinci
23-12-2023
6
2
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There are different genetic patterns for cardio-metabolic parameters among different populations. Additionally, it has been found that ancestral genetic components (the proportion of Amerindian, European and African) in admixed Latin American populations influence an individual’s susceptibility to cardio-metabolic disorders.
10p
vinarcissa
21-03-2023
1
1
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Understanding the relationship between genetic admixture and performances is crucial for the success of crossbreeding programs. Use of small sets of ancestry informative markers (AIMs) is a cost effective option to estimate the levels of admixture in situations where pedigree recording is difficult.
14p
vinarcissa
21-03-2023
4
1
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The frequencies of apolipoprotein L1 (APOL1) variants and their associations with chronic kidney disease (CKD) vary substantially in populations from Africa. Moreover, available studies have used very small sample sizes to provide reliable estimates of the frequencies of these variants in the general population.
9p
vinarcissa
21-03-2023
2
1
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Accurate identification of crop cultivars is crucial in assessing the impact of crop improvement research outputs. Two commonly used identification approaches, elicitation of variety names from farmer interviews and morphological plant descriptors, have inherent uncertainty levels.
11p
vinarcissa
21-03-2023
2
1
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Association studies are useful to unravel the genetic basis of common human diseases. However, the presence of undetected population structure can lead to both false positive results and failures to detect genuine associations.
11p
vihagrid
30-01-2023
7
3
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Accurate inference of genetic ancestry is of fundamental interest to many biomedical, forensic, and anthropological research areas. Genetic ancestry memberships may relate to genetic disease risks. In a genome association study, failing to account for differences in genetic ancestry between cases and controls may also lead to false-positive results. Although a number of strategies for inferring and taking into account the confounding effects of genetic ancestry are available, applying them to large studies (tens thousands samples) is challenging.
12p
vilarryellison
29-10-2021
13
0
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Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. Therefore, the genetic admixture may cause biased genetic association study with cancer susceptibility variants specifically in Hispanics.
14p
vijeeni2711
24-07-2021
9
0
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Osteoporosis, a disease characterized by low bone mineral density (BMD), is an important health problem in Mexico. BMD is a highly heritable trait, with heritability estimates of 50-85%. Several candidate genes have been evaluated to identify those involved in BMD variation and the etiology of osteoporosis.
8p
viannito2711
20-04-2021
12
1
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Estimation of individual ancestry from genetic data is useful for the analysis of disease association studies, understanding human population history and interpreting personal genomic variation. New, computationally efficient methods are needed for ancestry inference that can effectively utilize existing information about allele frequencies associated with different human populations and can work directly with DNA sequence reads.
11p
vikentucky2711
26-11-2020
15
1
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Admixed populations arise when two or more previously isolated populations interbreed. A powerful approach to addressing the genetic complexity in admixed populations is to infer ancestry. Ancestry inference including the proportion of an individual’s genome coming from each population and its ancestral origin along the chromosome of an admixed population requires
14p
vicolorado2711
22-10-2020
8
0
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XCIV and XCV are devoted to the trafficking venture of the year 1447, the unhappy fate of the Scandinavian Vallarte, and an expedition to the fisheries off the Angra dos Ruyvos. In Chapters XCVI and XCVII Azurara winds up his narrative, ending with the year 1448. The captives brought to Portugal down to that date by the various voyagers numbered, according to his estimate, 927, "the greater part of whom were turned into the true path of salvation"; and this he counts as the greatest of the Infant's glories, and the most valuable fruit of his lifelong efforts.
152p
chonguoinoiay1
02-04-2013
68
5
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