Animal models

Evaluate the analgesic effect of “Dinh Thong Phong” capsules on experimental animals. Subjects and methods: “Dinh Thong Phong” capsules, meeting the standard criteria, were evaluated for analgesic effect on white mice. In particular, the central analgesic effect was assessed using the hot plate model, peripheral analgesic effect was assessed using the writhing pain model.

4p vipanly 28-10-2024 0 0   Download

The purpose of this study was to create an animal model of a mandibular alveolar bone defect without compromising the animal’s well-being. Materials and methods: A total of 24 New Zealand white rabbits underwent surgery to create mandibular alveolar bone defects.

10p viengfa 23-10-2024 0 0   Download

A large number of studies have demonstrated the wound-healing effects of LLLT in vitro, in animal models, and in clinical practice. However, there are also differences in the study results, which are dose and wavelength dependent of LLLT. Evaluation of the wound healing process in experimental animals treated with low- level laser therapy in clinical and histopathology.

8p viengfa 23-10-2024 0 0   Download

The study was conducted from October 2016 to December 2017 at the Experimental Farm, Faculty of Animal Science, Vietnam National University of Agriculture, with the aim to evaluate the interaction between farming model types and reproductive performance of Ho and Dong Tao chickens.

9p vibecca 01-10-2024 2 1   Download

Animals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model to test the influence of histone modifications on behavior.

21p vimichaelfaraday 25-03-2022 13 1   Download

In diabetic patients, the body does not produce enough insulin or not properly respond to insulin. Insulin is a hormone produced by -cells of the pancreas. It stimulates the cells to absorb the glucose from the blood and its hyposecretion may leads to the over accumulation of glucose in the blood and often leading to various complications.

82p spiritedaway36 26-11-2021 18 2   Download

The present research reviewed previously published studies with the objective to enhance the understandings of the effects of different drugs on bone healing. There is clear evidence that antibiotics, corticosteroids, nonsteroidal inflammatory drugs, and chemotherapeutic drugs all affect bone healing.

11p chauchaungayxua12 09-07-2021 10 1   Download

Research objectives: Use the blended learning model in teaching to improve teaching efficiency and improve the online self-study capacity of human and animal physiology for biology pedagogy students.

27p thebadguys 08-06-2021 22 4   Download

This research with two aims: Establishing an animal model of autism using Swiss white mice by prenatal exposure to sodium valproate. Evaluating the effects of enriched environment on behaviors in modelled white mice

27p petsematary 02-06-2021 15 4   Download

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality in the world. Therefore, more and more studies are developing novel therapies to treat this disease. The pre-clinical trials on animals are a vital step to evaluate the efficacy as well as side effects of these novel therapies. Hence, this study aimed to develop the murine model of HCC using 3 kinds of mice: NOD/SCID, nude and Balb/c mice.

7p larachdumlanat127 02-01-2021 14 2   Download

The flesh fly Sarcophaga ruficornis is a pest of veterinary importance as it affects various animals reared for livestock including cows, buffaloes, sheep, and goats causing myiasis, which results in huge economic loss to the livestock owners. Various attempts have been made to control this fly using different chemical formulations. Barium carbonate is highly toxic compound upon acute and chronic exposures. Barium compounds have been found to have a toxic effect on different animal models.

10p kequaidan7 01-09-2020 16 2   Download

This article is devoted to the study of the attitude to organic food of residents of Southern Russia in connection with the development of a regional model of organic animal husbandry.

9p guineverehuynh 18-06-2020 10 2   Download

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 11 0   Download

Quantifying the multiple processes which control and modulate the extent of oral bioavailability for drug candidates is critical to accurate projection of human pharmacokinetics (PK). Understanding how gut wall metabolism and hepatic elimination factor into first-pass clearance of drugs has improved enormously. Typically, the cytochrome P450s, uridine 5′- diphosphate-glucuronosyltransferases and sulfotransferases, are the main enzyme classes responsible for drug metabolism. Knowledge of the isoforms functionally expressed within organs of first-pass clearance, their anatomical topology (e.

16p caothientrangnguyen 09-05-2020 18 0   Download

The purpose of this study was to evaluate the anti-inflammatory and the bronchodilator effects of Dinh Suyen P/H extract in experimental animals. The anti-inflammatory activity of Dinh Suyen P/H extract was evaluated in an induced peritoneal inflammation model in rats and amiant-induced granuloma model in mice.

9p cumeo4000 01-08-2018 19 0   Download

Oceans provide enormous and diverse space for marine life. Invertebrates are conspicuous inhabitants in certain zones such as the intertidal; many are soft- bodied, relatively immobile and lack obvious physical defenses. These animals frequently have evolved chemical defenses against predators and overgrowth by fouling organisms. Marine animals may accumulate and use a variety of toxins from prey organisms and from symbiotic microorganisms for their own purposes. Thus, toxic animals are particularly abundant in the oceans.

23p uocvong01 24-09-2015 63 7   Download

Most (78%) mitochondrial genomes in the studied mutant strain of Drosophila subobscura have undergone a large-scale deletion (5 kb) in the coding region. This mutation is stable, and is transmitted intact to the offspring. This animal model of major rearrangements of mitochondrial genomes can be used to analyse the involvement of the nuclear genome in the production and maintenance of these rearrangements.

8p research12 01-06-2013 50 6   Download

ProLiV - Animated Process-modeler of Complex (Computational) Linguistic Methods and Theories - is a fully modular, flexible, XML-based stand-alone Java application, used for computer-assisted learning in Natural Language Processing (NLP) or Computational Linguistics (CL).

4p hongphan_1 15-04-2013 58 4   Download

Protein aggregation is central to most neurodegenerative diseases, as shown by familial case studies and by animal models. A modified ‘amyloid cas-cade’ hypothesis for Alzheimer’s disease states that prefibrillar oligomers, also called amyloid-b-derived diffusible ligands or globular oligomers, are the responsible toxic agent. It has been proposed that these oligomeric spe-cies, as shown for amyloid-b, b2 -microglobulin or prion fragments, exert toxicity by forming pores in membranes, initiating a cascade of detrimental events for the cell. ...

10p awards 06-04-2013 40 3   Download

The herpes simplex virus thymidine kinase⁄ganciclovir (HSV-tk⁄GCV) sys-tem that selectively depletes cells expressing HSV-tk upon treatment with GCV has provided a valuable tool for developing a new animal model expressing the desired tissue damage. In this paper, an HSV-tk vector with an albumin promoter⁄enhancer was constructed. Based on the favourable killing effect on Hep-G2 cells by the recombinant construct, the HSV-tk transgenic mouse strains were developed.

9p awards 06-04-2013 52 2   Download