Anti-bacterial activity

FtsZ is conserved in almost all bacteria and is an essential protein for bacterial cell division. The cell division is prevented by the inhibitors against FtsZ’s functions. Thus, FtsZ is known as an attractive, and underexploited novel antibacterial target protein. The aim of this research is searching for new antibacterial agents from 72 plants collected in Central Vietnam.

6p viuchiha 03-01-2025 2 1   Download

A new series of transition metal complexes of Co(III), Ni(II) and VO(IV) was synthesized with the bidentate Schiff base ligand (HL) derived from the condensation of 2-amino-3-benzyloxypyridine and 5-bromo salicylaldehyde.

14p tocectocec 25-05-2020 26 2   Download

A group of new fluoroaniline Schiff bases (3a–3f) were synthesized and structurally characterized by various spectroscopic techniques such as 1H-NMR, LC-MS and FT-IR spectral studies.

8p tocectocec 25-05-2020 16 1   Download

A series of novel 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine linked various sulfonamide derivatives 8a-8j poly functionalized were designed and synthesized in moderate to good yield.

10p tocectocec 25-05-2020 14 1   Download

Ethanolic and aqueous (hot and cold) extracts of the fruit pulp, stem bark and leaves of Tamarindus indica were evaluated for antibacterial activity, in vitro, against 13 Gram negative and 5 Gram positive bacterial strains using agar well diffusion and macro broth dilution techniques, simultaneously.

12p tanbnhp 22-03-2014 49 6   Download

Members of the proline-rich antibacterial peptide family, pyrrhocoricin, apidaecin and drosocin appear to kill responsive bacterial species by binding to themultihelical lid region of the bacterial DnaK protein.Pyrrhocoricin, the most potent among these peptides, is nontoxic to healthy mice, andcanprotect these animals frombacterial challenge.

12p research12 23-04-2013 33 3   Download

Microcin J25 (MccJ25) is the single macrocyclic antimicro-bial peptidebelonging to the ribosomally synthesizedclass of microcins that are secreted byEnterobacteriaceae.Itshowed potent antibacterial activity against severalSalmonellaand Escherichiastrains and exhibited a compact three-dimen-sional structure [Blondet al. (2001) Eur. J. Biochem., 268, 2124–2133]. The molecular mechanisms involved in the biosynthesis, folding andmode of action of MccJ25 are still unknown.

11p tumor12 22-04-2013 44 2   Download

Peptides composed of leucyl and lysyl residues (
LK pep-tides) with different compositions and sequences were compared for their antibacterial activities usingcell wall-less bacteria of the classMollicutes(acholeplasmas, mycoplas-mas and spiroplasmas) as targets. The antibacterial activity of the amphipathica-helical peptides varied with their size, 15 residues beingthe optimal length, independent of the membrane hydrophobic core thickness and the amount of cholesterol.

11p fptmusic 16-04-2013 38 3   Download

Cationic antimicrobial peptides are naturally occurring antibiotics that are actively being explored as a new class of anti-infective agents. We recently identified three cathelicidin antimicrobial peptides from chicken, which have potent and broad-spectrum antibacterial activitiesin vitro (Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE & Zhang G (2006)J Biol Chem281, 2858–2867).

13p inspiron33 26-03-2013 51 4   Download

Antimicrobial peptides are effector molecules of the innate immune system. We have recently shown that peptides containing multiples of the heparin-binding Cardin and Weintraub motifs AKKARA and ARKKAAKA exert antimicrobial activities. Here, we show that replacement of lysine and arginine in these motifs by histidine abrogates the antibacterial effects of these peptides.

8p inspiron33 26-03-2013 48 4   Download

Cathelicidins are an important family of cationic host defense peptides in vertebrates with both antimicrobial and immunomodulatory activities. Fowlicidin-1 and fowlicidin-2 are two newly identified chicken cathelicidins with potent antibacterial activities. Here we report structural and func-tional characterization of the putatively mature form of the third chicken cathelicidin, fowlicidin-3, for exploration of its therapeutic potential.

11p inspiron33 23-03-2013 40 3   Download

Histidine-rich glycoprotein (HRGP), an abundant heparin-binding protein found in plasma and thrombocytes, exerts antibacterial effects against Gram-positive bacteria (Enterococcus faecalisand Staphylococcus aureus) and Gram-negative bacteria (Escherichia coliandPseudomonas aeruginosa). Fluorescence studies and electron microscopy to assess membrane permea-tion showed that HRGP induces lysis of E.

13p inspiron33 23-03-2013 51 5   Download

Fish skin mucus contains a variety of antimicrobial proteins and peptides that seem to play a role in self defense. We previously reported an antibac-terial protein in the skin secretion of the rockfish, Sebastes schlegeli, which showed selective antibacterial activity against Gram-negative bacteria. This study aimed to isolate and structurally and functionally characterize this protein.

12p inspiron33 23-03-2013 50 4   Download

Eppin has two potential protease inhibitory domains: a whey acid protein or four disulfide core domain and a Kunitz domain. The protein is also reported to have antibacterial activity against Gram-negative bacteria. Eppin and its whey acid protein and Kunitz domains were expressed in Escherichia coliand their ability to inhibit proteases and kill bacteria compared.

9p media19 06-03-2013 28 1   Download

The crystal structure of uridine monophosphate kinase (UMP kinase, UMPK) from the opportunistic pathogenUreaplasma parvumwas deter-mined and showed similar three-dimensional fold as other bacterial and archaeal UMPKs that all belong to the amino acid kinase family.

12p media19 05-03-2013 36 3   Download

Daptomycin and A21987C antibiotics are branched, cyclic, nonribosomally assembled acidic lipodepsipeptides produced byStreptomyces roseosporus. The antibacterial activity of daptomycin against Gram-positive bacteria strongly depends on the nature of the N-terminal fatty acid moiety.

7p vinaphone15 28-02-2013 28 3   Download

Whereas significant knowledge is accumulating on the antibacterial and antifungal properties of host defense peptides (HDPs) and their synthetic mimics, much less is known of their activities against parasites. A variety ofin vitro andin vivo antiparasitic assays suggest that these notorious anti-microbial compounds could represent a powerful tool for the development of novel drugs to fight parasites in the vertebrate host or to complement current therapeutic strategies

9p viettel02 20-02-2013 42 3   Download

Cell wall biosynthesis is a key target for antibacterial drugs. The major constituent of the bacterial wall, peptidoglycan, is a netlike polymer responsible for the size and shape of the cell and for resisting osmotic pres-sure. It consists of glycan chains of repeating disaccharide units cross-linked through short peptide chains.

9p viettel02 19-02-2013 47 3   Download

The human guanylate binding protein 5 (hGBP5) belongs to the family of interferon-c-inducible large GTPases, which are well known for their high induction by pro-inflammatory cytokines. The cellular role of this protein family is unclear at this point, but there are indications for antiviral and antibacterial activity of hGBP1.

9p mobifone23 18-01-2013 31 3   Download

Fish produce mucus substances as a defensive outer barrier against envi-ronmental xenobiotics and predators. Recently, we found a bioactive pro-tein in the mucus layer of the flounder Platichthys stellatus, which showed antibacterial activity against Staphylococcus epidermidis, Staphylococ-cus aureusand methicillin-resistantS. aureus.

13p mobifone23 18-01-2013 45 5   Download