Anti-proliferative activity

Green tea consumption has been shown to exhibit cancer-preventive activities in preclinical studies. Polyphenon E (Poly E) is a green tea standardized extract. This study was undertaken to examine the antiproliferative effect and pro-oxidant activity of Poly E on PC3 prostate cancer cells.

5p vifaye 20-09-2024 1 1   Download

Objectives of the dissertation: Structured design of coxib - combretastatin hybrid compounds. Synthesize coxib - combretastatin hybrid compounds. Screening for anti-cancer and anti-inflammatory activities of hybrid compounds. Identifying anti-inflammatory and anti-cancer mechanisms of hybrid compounds. Docking of a hybrid coxib - combretastatin compound with two purpose effect COX2 and tubulin.

27p extraenglish 24-05-2021 8 3   Download

Objectives of the dissertation: Structured design of coxib - combretastatin hybrid compounds; synthesize coxib - combretastatin hybrid compounds; screening for anti-cancer and anti-inflammatory activities of hybrid compounds; icreening for anti-cancer and anti-inflammatory activities of hybrid compounds.

27p capheviahe27 23-02-2021 14 3   Download

The silver and gold nanoparticles were biosynthesized using leaves of a pharmacologically important plant Heliconia rostrata.

8p tocectocec 25-05-2020 7 0   Download

PKR is an interferon-induced serine-threonine protein kinase that plays an important role in the mediation of the antiviral and antiproliferative actions of interferons. PKR is present at low basal levels in cells and its expression is induced at the transcriptional level by interferons. PKR’s kin-ase activity stays latent until it binds to its activator. In the case of virally infected cells, double-stranded (ds) RNA serves as PKR’s activator.

15p awards 06-04-2013 31 2   Download

Sanguinarine has been shown to inhibit proliferation of several types of human cancer cell including multidrug-resistant cells, whereas it has min-imal cytotoxicity against normal cells such as neutrophils and keratino-cytes. By analyzing the antiproliferative activity of sanguinarine in relation to its effects on mitosis and microtubule assembly, we found that it inhibits cancer cell proliferation by a novel mechanism.

12p inspiron33 26-03-2013 41 3   Download

Physalis philadelphicaLam, commonly known as a tomatillo, is a staple of the Mesoamerican cuisine. In our laboratory, an ethyl acetate-soluble extract and four withanolides [ixocarpalactone A (IxoA), ixocarpalac-tone B, philadelphicalactone B, and withaphysacarpin] were isolated. Stud-ies conducted on Hepa-1c1c7 hepatoma cells revealed that withanolides were potent inducers of quinone reductase, suggesting possible cancer chemo-protective activity.

10p inspiron33 23-03-2013 36 3   Download

Vanadium exerts a variety of biological effects, including antiproliferative responses through activation of the respective signaling pathways and the generation of reactive oxygen species. As epidermal cells are exposed to environmental insults, human keratinocytes (HaCaT) were used to investi-gate the mechanism of the antiproliferative effects of vanadyl(IV) sulfate (VOSO4).

16p vinaphone15 25-02-2013 30 1   Download

Thymoquinone, a naturally derived agent, has been shown to possess anti-oxidant, antiproliferative and proapoptotic activities. In the present study, we explored thymoquinone effects on the proteasomal complex, the major system involved in the removal of damaged, oxidized and misfolded pro-teins.

14p mobifone23 21-01-2013 39 4   Download