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Anti-tubercular drugs
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Ketoprofen and isoniazid together are a potential combination of a nonsteroidal antiinflammatory drug and an antitubercular medicine to treat tuberculosis and associated symptoms like fever and fatigue. The Schiff base of isoniazid with ketoprofen is synthesized in this research. Infrared spectroscopy (IR) and X-ray diffraction (XRD) analysis of the crystal packing proved the formation of the Schiff base and the existence of N-H···O hydrogen bonds between the hydrogen-bonded dimer of the Schiff base.
23p
tudichquannguyet
29-11-2021
15
0
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A series of 3-mercapto-1,2,4-triazole–pyrrole hybrids was designed as antimycobacterial agents by employing 5- (4-(1H -pyrrol-1-yl)phenyl)-4H -1,2,4-triazole-3-thiol as the scaffold onto which several types of moieties were introduced in the triazole ring at N-4 and N-2 and as substituents of the mercapto function. The aforementioned moieties are an allyl or a phenyl moiety at N-4; an aminomethyl group at N-2; or methyl, substituted benzyl, ethoxycarbonylmethyl, or substituted phenacyl at sulfur.
16p
tudichquannguyet
29-11-2021
9
1
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The study describes the synthesis, characterization, in vitro antimicrobial and anticancer evaluation of a series of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamide derivatives. The synthesized derivatives were also assessed for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv.
14p
vijiraiya2711
27-05-2020
15
1
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Tuberculosis has proved harmful to the entire history of mankind from past several decades. Decaprenyl-phosphorylribose 2′-epimerase (DprE1) is a recent target which was identified in 2009 but unfortunately it is neither explored nor crossed phase II.
12p
vijiraiya2711
27-05-2020
10
1
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Tuberculosis is an air-borne disease, mostly affecting young adults in their productive years. Here, Ligand-based drug design approach yielded a series of 23 novel 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives.
11p
vijiraiya2711
27-05-2020
14
1
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Tuberculosis (TB) is a major public health problem in India and a leading cause of death in adults, especially among the economically productive age group. Historically TB has been associated with significant morbidity and mortality and remains a major global health problem.
11p
nguaconbaynhay1
04-12-2019
50
1
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