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Anticancer properties
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In this study, green-synthesized zinc oxide nanoparticles (ZnO NPs) were surface-modified with pluronic F-127 after being synthesized using the leaf extract of guava (Psidium guajava). The resulting material, ZnO@F-127, was then characterized, and its anticancer activity was evaluated on several cell lines.
8p
viambani
18-06-2024
3
1
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The wave function regards like localized orbital locator, electron localized function, average localized ionization energy and non-covalent interaction are also examined as a means of theoretical evidence of the titled compound. The NBO calculations probe the intermolecular and intramolecular movement of charges, and additionally the molecule's stability. The ADMET properties are also considered for the compound with the assistance of Swiss ADMET online tool.
17p
dianmotminh02
03-05-2024
1
1
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The present study investigated the phytochemical and biological properties of the rhizomes C. aromatica. From the CHCl3 extract of C. aromatic rhizomes, six known compounds, including (-)-hannokinol, (3R,5R)-3,5-diacetoxy-1,7-bis(4- hydroxyphenyl)heptane, naringenin, 2-(4- (hydroxymethyl)phenyl)propan-2-ol, 5-hydroxymethylfurfural, and bisacurone, were isolated. All compounds were tested on the biological inhibitory activities against tyrosinase, αglucosidase, and urease. It was the first time all compounds were isolated from rhizomes of C. aromatica Salisb.
6p
dianmotminh02
03-05-2024
2
2
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Ebook "Medicinal chemistry and pharmacological potential of fullerenes and carbon nanotubes" particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.
411p
manmanthanhla0201
27-02-2024
3
1
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The Indian leadwort (Plumbago indica L.) of the family Plumbaginaceae is a plant with high pharmaceutical value, as it contains plumbagin, a naphthoquinone with antibacterial, antifungal and anticancer properties. Among the propagation methods for the Indian leadwort, in vitro propagation is considered an effective method in producing disease-free transplants in a short period of time with high propagation rate.
10p
vicaptainmarvel
21-04-2023
4
2
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Cephalotaxus mannii Hook.f is a rare medicinal plant used for the treatment of leukemia, however, its fungal endophytes with antibacterial and anticancer properties have not been exploited yet. In this study, six fungal isolates were recovered from roots of C. mannii collected in Ha Giang province, Vietnam.
11p
vicaptainmarvel
21-04-2023
4
2
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Over the past decades, researchers and scientists have paid more and more attention to the discovery of novel antibiotics and anticancer agents in fighting infection and cancer diseases. It is believed that endophytic actinomycetes from medicinal plants provide abundant resources for new compounds with significant bioactive properties. In the present study, we assessed antibacterial and cytotoxic activities of endophytic actinomycetes associated with Litsea cubeba (Lour.) Pers.
11p
vidudley
20-02-2023
7
2
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Nano-sized materials have shown to have very high potential in anticancer therapy by an adequate tuning of their functionalization and physico-chemical properties. This study is focused on the synthesis and characterization of mesoporous silica nanoparticles (MSN) functionalized with a titanium(IV) or an organotin(IV) compound (therapeutic agents), fluorescein isothiocyanate (image agent) and transferrin (targeting molecule).
15p
vironald
15-12-2022
8
2
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Extranodal natural killer/T cell lymphoma (NKTCL) is a highly aggressive type of non-Hodgkin lymphoma that facing the treatment challenges. Natural compounds are important sources for drug development because of their diverse biological and chemical properties, among which terpenoids have strong anticancer activities.
10p
vikolindagrabar
27-07-2022
3
1
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5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent.
10p
vidarwin
23-02-2022
12
1
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Isatin, 1H -indoline-2,3-dione, an endogenous compound, is also a synthetically versatile molecule that possesses a diversity of biological activities including anticonvulsant, antibacterial, antifungal, antiviral, anticancer, and cytotoxic properties. Based on the promising cytotoxic activity studies on N -substituted isatin derivatives, a series of 18 derivatives of 2-(2,3-dioxo-2,3-dihydro-1H -indol-1-yl)-N -phenylacetamide were designed, synthesized, and characterized according to their analytical and spectral data.
9p
langthannam
29-12-2021
10
0
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Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents.
9p
langthannam
29-12-2021
9
0
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The morphology and doping levels were observed to have a collective effect on the anti-proliferation activity of GaOOH with specificity in treating certain cancer cells.
13p
meyerowitz
25-12-2021
6
1
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The aim of this study was to obtain an oil extract from a Bulgarian green microalga strain Coelastrella sp. BGV and to assess its anticancer and apoptogenic activity in vitro against human tumor cells HeLa by means of MTT and fluorescence microscopy analyses. The results showed that the oil extract obtained by a direct extraction using a common vegetable oil reduces proliferation and induces apoptosis in HeLa cells.
3p
mudbound
10-12-2021
16
1
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Therefore, in this study, we examined the biological and pharmaceutical properties, focusing on cell-targeted toxicity, organism-targeted toxicity (zebrafish) and anticancer activity on cervical cancer in vitro, of the ethanol extract of the medicinal plant C. kongensis (CK-EE), an endemic plant of Vietnam used as traditional medicine for a long period.
7p
guitaracoustic02
08-12-2021
18
2
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In this study, novel 2-substituted benzimidazoles molecules having triazole, thiadiazole, and oxadiazole rings were synthesized and were evaluated by anticancer, antioxidant/oxidant status, genotoxicity, and antiangiogenesis assays. Anticancer activity of the compounds was determined by MTT (0.5, 5, and 50 µg/mL) and lactate dehydrogenase (LDH) release assays against human prostate and breast cancer cells. Oxidative status of cells was elicited by total oxidative stress and total antioxidant capacity methods.
20p
tudichquannguyet
29-11-2021
10
1
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Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)- based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated.
12p
tudichquannguyet
29-11-2021
8
1
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Isoquercitrin is a flavonoid chemical compound that can be extracted from different plant species such as Mangifera indica (mango), Rheum nobile, Annona squamosal, Camellia sinensis (tea), and coriander (Coriandrum sativum L.). It possesses various biological activities such as the prevention of thromboembolism and has anticancer, antiinflammatory, and antifatigue activities. Therefore, there is a critical need to elucidate and predict the qualitative and quantitative properties of this phytochemical compound using the high performance liquid chromatography (HPLC) technique.
13p
tudichquannguyet
29-11-2021
12
1
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Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications.
20p
tudichquannguyet
29-11-2021
12
1
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Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. It is known that alterations in the DNA methylation pattern and/or the loss of specific histone acetylation/methylation markers are related to several hallmarks of cancer, such as drug resistance, stemness, epithelial–mesenchymal transition, and metastasis.
16p
thiencuuchu
27-11-2021
9
1
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