Anticoagulant activity

Distichochlamys citrea (DC) is an endemic ginger species used in treating associatedheart diseases in traditional medicine in Vietnam. However, scientific evidence to support the local use of this plant was limited. The present study aimed to investigate the antioxidant and antithrombotic activities of D. citrea extracts for the first time. The antioxidant activity of DC extracts was assessed by scavenging DPPH radical and measuring their total phenolic content (TPC). The antithrombotic activity was evaluated by inhibiting platelet aggregation and prolonging blood coagulation.

17p xuanphongdacy06 18-09-2024 3 1   Download

In this work, a new sulfated polysaccharide was isolated from green seaweed Caulerpa racemosa harvested at Nha Trang sea. The structure of obtained polysaccharide was determined and its cytotoxic activity was evaluated. The results showed that structure of the polysaccharide has a main chain of (1→4)-β-D-galactopyranose residues and branches are (1→3)-α-L-glucopyranose-2,4-disulfate residues linked to the main chain at C-6 position.

6p dianmotminh02 03-05-2024 11 2   Download

The purposes of the dissertation: Preparation of low molecular weight sodium alginate from brown algae in Nha Trang Bay which has anticoagulant activity as a raw material for functional food production.

36p tunelove 11-06-2021 23 3   Download

The objectives of the thesis: Research in the toxin/protein having bioactive isolated from Heterometrus laoticus (H. laoticus) scorpion and krait Bungarus fasciatus (B. fasciatus) snake venom.

32p extraenglish 24-05-2021 13 3   Download

The objectives of the thesis: Research in the toxin/protein having bioactive isolated from Heterometrus laoticus (H. laoticus) scorpion and krait Bungarus fasciatus (B. fasciatus) snake venom.

32p extraenglish 24-05-2021 21 3   Download

Annexin B1 fromCysticercus cellulosaehas recently been identified using immunological screening in an attempt to find novel antigens for vaccine development against cysticercosis. The protein possesses anticoagulant activity and carries significant therapeutic potential due to its thrombus-targeting and thrombolytic properties.

10p inspiron33 25-03-2013 34 5   Download

Mouse anticoagulant protein C (461 residues) shares 69% sequence identity with its human ortholog. Interspecies experiments suggest that there is an incompatibility between mouse and human protein C, such that human protein C does not function efficiently in mouse plasma, nor does mouse protein C function efficiently in human plasma.

17p viettel02 20-02-2013 32 2   Download

Protein C inhibitor (PCI; SERPINA5) is a plasma serine protease inhibitor, and a potent inhibitor of activated protein C (APC), which plays a critical role in the anticoagulant protein C pathway. Recently, PCI was also found to form a complex with the serine protease hepatocyte growth factor activator (HGFA), inhibiting the HGFA-catalyzed activation of the single-chain hepatocyte growth factor precursor.

7p mobifone23 21-01-2013 44 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin

10p panasonic01 13-12-2011 41 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anticoagulant properties of drotrecogin alfa (activated) during hemofiltration in patients with severe sepsis...

2p coxanh_3 27-10-2011 52 4   Download

Vaccine Patients recovering from tetanus should be actively immunized (see below) because immunity is not induced by the small amount of toxin required to produce disease. Additional Measures Like all patients receiving ventilatory support, patients with tetanus require attention to hydration; nutrition; physiotherapy; prophylactic anticoagulation; bowel, bladder, and renal function; decubitus ulcer prevention; and treatment of intercurrent infection.

8p colgate_colgate 21-12-2010 52 2   Download

Disseminated Intravascular Coagulation DIC is a clinicopathologic syndrome characterized by widespread intravascular fibrin formation in response to excessive blood protease activity that overcomes the natural anticoagulant mechanisms. DIC is associated with several underlying pathologies (Table 110-2). The most common causes are bacterial sepsis, malignant disorders such as solid tumors or acute promyelocytic leukemia (APL), and obstetric causes. DIC is diagnosed in almost half of pregnant women with abruptio placentae or with amniotic fluid embolism.

6p thanhongan 07-12-2010 69 3   Download

The central mechanism of DIC is the uncontrolled generation of thrombin by exposure of the blood to pathologic levels of tissue factor (Fig. 110-3). Simultaneous suppression of physiologic anticoagulant mechanisms and abnormal fibrinolysis further accelerate the process. Together these abnormalities contribute to systemic fibrin deposition in small and mid-sized vessels. The duration and intensity of the fibrin deposition can compromise the blood supply of many organs, especially the lung, kidney, liver, and brain, with consequent organ failure.

5p thanhongan 07-12-2010 67 3   Download