Anticonvulsant activity

Isatin, 1H -indoline-2,3-dione, an endogenous compound, is also a synthetically versatile molecule that possesses a diversity of biological activities including anticonvulsant, antibacterial, antifungal, antiviral, anticancer, and cytotoxic properties. Based on the promising cytotoxic activity studies on N -substituted isatin derivatives, a series of 18 derivatives of 2-(2,3-dioxo-2,3-dihydro-1H -indol-1-yl)-N -phenylacetamide were designed, synthesized, and characterized according to their analytical and spectral data.

9p langthannam 29-12-2021 10 0   Download

A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3H)- ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3H)-ones, and 2,3-dihydroquinazolin-4(1H)-ones were obtained at yields of 46% to 95% by a one-pot reaction of N -(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions.

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The presented work is devoted to the development of synthesis methods for novel 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1H -1,2,4-triazolo]anilines. Abovementioned compounds were obtained via hydrazinolysis (Ing-Manske procedure) and acid hydrolysis of corresponding N -acylated{([1,2,4]triazolo[1,5- c ]quinazolin-2-yl)alkyl-(alkaryl-, aryl-)}amines. The regioselectivity of hydrazinolysis and hydrolysis were established. The features of spectral characteristics were studied and discussed.

10p tudichquannguyet 29-11-2021 10 1   Download

Evolvulus nummularius, is ethnomedicinally used as a medicine for hysteria, to cure burns, cuts, wounds and scropion stings. This plant has antihelminthic activity, wound healing activity, poor sedative and anticonvulsant properties. In this study, the antibacterial activity of crude methanol extract of E. nummularius was studied against three gram negative multidrug resistant strains E. aerogenes, P. aeruginosa and K. pneumoniae. This plant extract showed both bacteriostatic and bactericidal activity against all these bacterial strains. The extract was most active against E. aerogenes.

8p nguaconbaynhay6 23-06-2020 8 1   Download

The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc.

12p vijiraiya2711 27-05-2020 10 1   Download

Medicinal plants are the base of traditional system of medicine and herbal industry for the development of new drug. The A. marmelos is also known as bael, wooden apple, belo and bilwa. The important phytochemicals isolated from various parts of the plant are alkaloids, cardiac glycoside, saponin, steroids, coumarines terpenoids, phenylpropenoids, tannins, polysaccharides and flavonoids.

9p nguathienthan2 19-12-2019 12 0   Download

The long term use of antiepileptic drugs possesses many unwanted effects; thus, new safe combinations are urgently mandated. Hence, the present study aimed to investigate the anticonvulsant effect of kava alone or in combination with a synthetic anticonvulsant drug, diazepam (DZ). To this end, female Wistar rats were divided into two subsets, each comprising 6 groups as follows: group (i) received 1% Tween 80 p.o. and served as control, while groups (ii) and (iii) received kava at two dose levels (100 and 200 mg/kg, p.o.). The remaining three groups received (iv) DZ alone (10 mg/kg p.o.

8p kethamoi1 17-11-2019 17 1   Download

Quantitative structure-activity relationship and molecular docking studies were carried out on a series of quinazolinonyl analogues as anticonvulsant inhibitors. Density Functional Theory (DFT) quantum chemical calculation method was used to find the optimized geometry of the anticonvulsants inhibitors. Four types of molecular descriptors were used to derive a quantitative relation between anticonvulsant activity and structural properties. The relevant molecular descriptors were selected by Genetic Function Algorithm (GFA).

11p kequaidan1 16-11-2019 16 1   Download

This review provides an up to date information about the diverse pharmaceutical activities of formazans. The bibliography includes 97 references which have been published during the period from 1980 to 2013. The covered biological activities of the title compounds include antioxidant, anticonvulsant, therapeutic, anthelmintic, anti-tubercular, antiviral, anti-inflammatory, anticancer, anti-HIV, antimicrobial, antiparkinsonian, cardiovascular and antiproliferative activities.

14p trinhthamhodang1 16-11-2019 18 1   Download

Aneja et al. Organic and Medicinal Chemistry Letters 2011, 1:15 http://www.orgmedchemlett.com/content/1/1/15 ORIGINAL Open Access Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents Deepak K Aneja1*, Poonam Lohan1, Sanjiv Arora1, Chetan Sharma2, Kamal R Aneja2 and Om Prakash3† Abstract Background: Thiazolidine-2, 4-diones (TZDs) have become a pharmacologically important class of heterocyclic compounds since their introduction in the form of glitazones into the clinical use for the treatment of type 2 diabetes.

11p dauphong13 10-02-2012 67 5   Download

Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Recent studies indicate that histone deacetylase is a direct target of valproic acid. Methods: In the present study, we have used histological analysis and RT-PCR assays to examine the cardiac abnormalities in mice treated with sodium valproate (NaVP) and determined the effects of NaVP on histone deacetylase activity and the expression...

7p toshiba23 18-11-2011 64 9   Download