Antifungal evaluation

The combination of antifungal drugs for the treatment of dermatophytosis, including oral itraconazole and topical terbinafine, has been shown to be more effective than monotherapy. To describe the clinical characteristics and evaluate the results of patients with dermatophytosis treated with the combination of oral itraconazole and topical terbinafine at Can Tho Hospital of Dermato-Venereology in 2023.

7p vikoch 27-06-2024 1 1   Download

In this research, a single-step polymeric novel particle was synthesized from oak bark extract by nanoemulsion polymerization technique for the first time in the literature. It has been shown that the synthesized particles are achieved without losing any antioxidant and antibacterial properties of the oak bark extract. In this study, the p(OB) particles were reported for the first time and were characterized in terms of antioxidant, blood compatible, H2O2 scavenging, antibacterial, and antifungal potential to evaluate their use in biocompatible materials with drug release system potential.

13p dianmotminh02 03-05-2024 3 1   Download

The present study aims to investigate the potential of the new formulations including silver (I) nanoparticles as well as copper (II) and zinc (II) chelates in their separated and complex forms in the treatment of infectious diseases. The capacity of metallic ion based systems to suppress the development of microorganism often seen on wounds, such as Gram-negative bacteria (Klebsiella pneumonia ATCC 700603, Pseudomonas aeruginosa ATCC 27853), Gram-positive bacteria (Staphylococcus aureus ATCC 29213), and fungi (Candida albicans ATCC 10231) were evaluated by microdilution assay.

6p giangnhanly 02-10-2023 3 3   Download

We have known that plant defensins have the main roles in biotic stress, especially antifungal activities. In addition, their functions on abiotic stress tolerance have been demonstrated on previous studies, but that information was still limited.

13p vimulcahy 18-09-2023 9 3   Download

Using the natural agents with inhibitory activity against digestive enzymes α-glucosidase and αamylase capable of hydrolyzing carbohydrates into glucose to reduce blood glucose levels in the blood is one of the effective strategies to control diabetes, especially type II diabetes. α-Mangostin (AMG) was proven to have strong biological activities, such as antifungal, antibacterial, anti-inflammatory, anti-cancer.

9p vimulcahy 18-09-2023 2 2   Download

Purple amomum (Amomum longiligulare T.L. Wu), which belongs to the monophyletic Zingiberaceae family, is a valuable medicinal plant in Vietnam. The studies on the biological activities of the extracts or essential oils of this species are very limited. So far, there has been no evaluation of the antifungal activity of purple amomum extracts.

11p viberkshire 09-08-2023 8 4   Download

Lifestyle factors such as hair length, the frequency of ear cleaning and bathing, age, cat rearing, and sex may contribute to opportunistic yeast infections in the external ear canal of cats. This study aimed to determine the prevalence of commensal yeast organisms in cats’ external ear canals, evaluate their predisposing lifestyle factors, and test the susceptibility of Malassezia pachydermatis to antifungal agents.

8p vidarwin 23-02-2022 9 1   Download

Around 200 different lipopeptides (LPs) have been identified to date, most of which are produced via Bacillus and Pseudomonas species. The clinical nature of the lipopeptide (LP) has led to a big surge in its research. They show antimicrobial and antitumor activities due to which mass-scale production and purification of LPs are beneficial. Response surface methodology (RSM) approach has emerged as an alternative in the field of computational biology for optimizing the reaction parameters using statistical models. In the present study, Pseudomonas sp.

16p langthannam 29-12-2021 10 0   Download

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13–22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1,4–12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillinresistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.

5p langthannam 29-12-2021 8 0   Download

New 2-(imidazo[1,2-a]pyridin-2-ylcarbonyl)-N -substituted hydrazinecarbothioamides (4a–j), N ’-(3-substituted-4-oxo-1,3-thiazolidin-2-ylidene)imidazo[1,2- a]pyridine-2-carbohydrazides (5a–f), and N -(nonsubstituted/4-substituted phenyl)-5-(imidazo[1,2-a]pyridine-2-yl)-1,3,4-oxadiazole-2-amines (6a–d) were synthesized from imidazo[1,2-a]pyridine-2-carbohydrazide (3) and evaluated for antifungal activity against Microsporum gypseum NCPF 580, M. canis, Trichophyton tonsurans NCPF 245, T. rubrum, Candida albicans ATCC 10231, and C. parapsilosis ATCC 22019 using amphotericin B as the standard.

11p langthannam 29-12-2021 11 0   Download

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a–j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a–j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells.

10p langthannam 29-12-2021 8 1   Download

A new, less expensive, solvent-free procedure was developed for the synthesis of some new derivatives of various fused heterocyclic ring systems, namely azolopyridazine, azolotriazine, azinotriazine, thienopyridine, and pyrazolopyridine. The structures of the products prepared were established by their spectral data and elemental analyses. Eight compounds were evaluated for their in vitro antimicrobial activity. Some of the tested compounds exhibited moderate to significant antibacterial and antifungal activities.

15p langthannam 29-12-2021 9 0   Download

All the complexes showed nonelectrolytic behavior. Moreover, the newly synthesized mixed ligand complexes were evaluated for their in vitro antimicrobial efficiency against bacteria and yeast. The compound named Co(L1 L) had good antifungal activity against Candida species, but no profound antibacterial effect against bacterial strains.

13p langthannam 29-12-2021 9 1   Download

The antimicrobial activity of the products was evaluated and the results revealed that compounds 8f and 15f showed strong activity against gram-positive bacteria while compound 15d showed the highest activity against gramnegative bacteria. Moreover, compounds 15b, 8d, 8e, 8c, 8l, and 8j exhibited significant antifungal activity. In addition, the antitumoral activity of the synthesized products against different cancer cell lines was determined and the results revealed that compound 12c was the most active against MCF-7, HepG-2, HCT-116, and HeLa with IC50 values of 0.51, 0.72, 0.95, and 0.

22p langthannam 29-12-2021 14 0   Download

The in-vitro antifungal effect of 09 different treatments (07 plants based = black pepper, red pepper, turmeric, clove, garlic, onion and papaya seed and 02 chemical preservatives = Potassium metabi-sulphate, PMS and Sodium benzoate, SB) showed significant (P < 0.05 = 0.0000) variation among the treatment groups.

6p mudbound 10-12-2021 6 1   Download

These results revealed strain-dependent antifungal activity. Our study indicates that the use of these lactic acid bacteria can be applied as a biocontrol of fungal growth and mycotoxins production.

6p mudbound 10-12-2021 4 1   Download

Plant defensins are small (45–54 amino acids), basic, cysteine-rich proteins that have a major role in innate immunity in plants. Many defensins are potent antifungal molecules and are being evaluated for their potential to create crop plants with sustainable disease resistance.

13p vijichea2711 28-05-2021 8 1   Download

The present in vitro study was conducted with aim to know the antifungal activity of three bio-agents (Trichoderma viride, Pseudomonas fluorescens and Bacillus subtilis), Neem oil and amendments (FYM and Neem cake) against Sclerotium rolfsii causing Stem rot in groundnut. The study was conducted in Plant Pathology laboratory, SHUATS during 2020.

8p trinhthamhodang11 27-04-2021 11 1   Download

The present study was done to evaluate the antifungal susceptibility pattern of Candida species by Disc diffusion method which is helpful for guiding therapy. All clinical samples sent to the Microbiology laboratory were inoculated on to Blood agar and MacConkey agar. The suspected colonies of Candida were identified by Gram stain and inoculated onto CHROM Candida differential agar for speciation.

6p trinhthamhodang11 27-04-2021 11 1   Download

The study also revealed that the antifungal effects of silver nanoparticles are positively correlated to the concentration of nanoparticles as well as the time of exposure. Further, it can be exploited as an alternative for chemical management in the future.

5p chauchaungayxua11 23-03-2021 7 1   Download