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Antigen processing
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Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process.
14p
vibransone
28-03-2024
2
1
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Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, generated in vitro and therefore lacking information about antigen processing.
15p
vibransone
28-03-2024
4
1
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Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association between polygenic risk of depression and DNA methylation is unknown.
16p
viellison
28-03-2024
3
2
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Part 1 book "Veterinary immunology" includes content: Surviving in a microbial world; innate immunity; humoral innate immunity; humoral innate immunity; cellular innate immunity; cellular innate immunity; sickness; how immune cells communicate; antigens; dendritic cells and antigen processing; the major histocompatibility complex; organs of the immune system; lymphocytes; helper t-cells and their response to antigens; b-cells and their response to antigens; antibodies.
504p
muasambanhan03
02-01-2024
9
2
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Part 1 book "Veterinary immunology" includes content: The defense of the body, innate immunity, innate immunity, innate immunity, innate immunity, systemic responses to inflammation; innate immunity; cell signaling; antigens; dendritic cells and antigen processing; the major histocompatibility complex; organs of the immune system; lymphocytes; helper t'cells and their response to antigen; b'cells and their response to antigen 16 antibodies; how antigen binding receptors are made,... and other contents.
324p
muasambanhan03
02-01-2024
2
2
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The roles of low molecular mass polypeptide 2 (LMP2) and transporter-associated with antigen processing (TAP2) in tumorigenesis are controversial. Here we aimed to explore the effect of LMP2 and TAP2 on the oncogenesis and metastasis of cervical cancer cells.
10p
vileonardodavinci
23-12-2023
5
2
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Transporter associated with antigen processing 1 (TAP1) is a molecule involved in processing and presentation of major histocompatibility complex class I restricted antigens, including tumor-associated antigens. TAP1 participates in tumor immunity, and is aberrantly expressed in multiple cancer types.
17p
vischultz
20-10-2023
1
1
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ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding.
11p
vischultz
20-10-2023
4
1
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The ubiquity-proteasome system is an indispensable mechanism for regulating intracellular protein degradation, thereby affecting human antigen processing, signal transduction, and cell cycle regulation. We used bioinformatics database to predict the expression and related roles of all members of the PSMD family in ovarian cancer.
18p
visharma
20-10-2023
2
2
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Part 1 book "Vaccine adjuvants and delivery systems" includes content: Development of vaccine adjuvants - a historical perspective, antigen processing and presentation, mechanisms of adjuvant action; aluminum containing adjuvants - properties, formulation, and use - TLR4 agonists as vaccine adjuvants, immunostimulatory CPG oligodeoxynucleotides as vaccine adjuvants,... and other contents.
202p
oursky05
20-09-2023
3
1
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Part 1 book "Basic veterinary immunology" includes content: Overview of mechanisms of defense, overview of the innate immune system, innate immune recognition, the complement system, acute inflammation, innate cellular effector mechanisms, antigens and antigen processing, cells and organs of the adaptive immune system.
155p
oursky05
20-09-2023
7
2
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Nghiên cứu được thực hiện nhằm xác định tần số alen và tần số kiểu gen của đa hình gen alpha (1, 2) fucosyltransferase (FUT1) và gen transporter associated with antigen processing (TAP1) ở 25 giống lợn bản địa Việt Nam và 1 giống lợn ngoại.
7p
viintuit
06-09-2023
10
1
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Animal cloning is the process of producing an entire organism that theoretically has the same genome as its donor cell line. To validate the success of SCNT, one must verify that the genetic source of the cloned organism is identical to the donor cell. However, none of the studies have performed to identify the genetic characteristics in the stage of preimplantation development of cloned embryo.
8p
vimalfoy
08-02-2023
1
1
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B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor (BCR) genes and selection by their ability to bind antigens.
11p
vijeeni2711
30-06-2021
12
1
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The genes that produce antibodies and the immune receptors expressed on lymphocytes are not germline encoded; rather, they are somatically generated in each developing lymphocyte by a process called V(D)J recombination, which assembles specific, independent gene segments into mature composite genes. The full set of composite genes in an individual at a single point in time is referred to as the immune repertoire.
10p
vioklahoma2711
19-11-2020
6
1
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GATK Best Practices workflows are widely used in large-scale sequencing projects and recommend post-alignment processing before variant calling. Two key post-processing steps include the computationally intensive local realignment around known INDELs and base quality score recalibration (BQSR).
13p
vioklahoma2711
19-11-2020
9
1
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Bcl-2 (B cell lymphoma/leukemia gene-2) is the first proto-oncogene recognized to function by inhibiting programmed cell death/apoptosis. Although much is known about the anti-apoptotic ability of Bcl-2, little information is available concerning its function in other cellular processes, such as cell differentiation.
8p
viamsterdam
18-09-2020
9
0
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Canine parvovirus is the major cause of haemorrhagic gastroenteritis in canines worldwide. There is a high morbidity and mortality in the young puppies. The currently available CPV vaccine is protecting from all antigenic strains but still there is vaccination failure as the strains are emerging at higher rate.
6p
angicungduoc6
22-07-2020
7
1
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Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and are associated with the risk of diseases.
11p
viorochimaru2711
01-06-2020
6
1
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The production of recombinant monoclonal antibodies in mammalian cell culture is of high priority in research and medical fields. A critical step in this process is the isolation of the antigen-binding domain sequences of antibodies possessing the desired properties.
14p
viuchiha2711
21-04-2020
4
1
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