Antimicrobial spectrum
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Tigecycline has a broad spectrum of antimicrobial activity and has been approved for the treatment of complicated intra-abdominal infections. However, it is debatable whether tigecycline should be used alone or in combination.
8p vioracle 29-09-2023 6 2 Download
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Escherichia coli (E. coli) is one of the leading causes of infections in cancer patients. Antibiotic-resistant E. coli is a major cause of treatment failure in infected cancer patients. This study aims to determine the prevalence and antibiotic susceptibility of E. coli in cancer patients from January 2022 to December 2022 at National Cancer Hospital.
8p vicaptainmarvel 21-04-2023 5 2 Download
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In this study, a new formulation based on the combination of two active constituents (zinc pyrithione and triclosan) and an inactive component (carboxymethyl cellulose polymer) was optimized for seed coating to control seed-borne pathogens. According to the in vitro antimicrobial tests, the combination of zinc pyrithione and triclosan showed a broader spectrum of phytopathogenic bacteria and fungi control.
12p lyhuyenthu 31-01-2023 6 2 Download
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Antimicrobial peptides play important roles in both plant and animal defense systems. Moreover, over-expression of CaAMP1 (Capsicum annuum antimicrobial protein 1), an antimicrobial protein gene isolated from C. annuum leaves infected with Xanthomonas campestris pv. vesicatoria, confers broad-spectrum resistance to hemibiotrophic bacterial and necrotrophic fungal pathogens in Arabidopsis.
10p vihagrid 30-01-2023 6 3 Download
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This study compared the bacterial spectrum and antibiotic susceptibility of uropathogens in older and younger patients with urinary stones to provide appropriate antibiotic management. Methods: We retrospectively reviewed urinary tract infection patients with urolithiasis, presented to Xiangya Hospital from March 2014 to April 2021.
9p vinobelprisen 26-03-2022 13 4 Download
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The problem of increasing resistance against conventional antibiotics has drawn people’s attention. Therefore, the development of novel antibacterial agents with effective and safe therapeutic effects is imminent. Antimicrobial peptides (AMPs) are considered a promising class of antibacterial agents due to their broad antibacterial spectrum.
16p vigandhi 23-02-2022 12 1 Download
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Antimicrobial resistance (AMR) is an increasing global health concern reducing options for therapy of infections and also for perioperative prophylaxis. Many Enterobacteriaceae cannot be treated anymore with third generation cephalosporins (3GC) due to the production of certain 3GC hydrolysing enzymes (extended spectrum beta-lactamases, ESBLs).
12p vigandhi 23-02-2022 17 2 Download
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The LAB isolates were screened for antimicrobial activity. Out of 142 isolates only 68 isolates exhibited antimicrobial activity. Among these isolates, nine showed wide spectrum antimicrobial activity as well as good bile salt, acid and phenol tolerance.
11p schindler 30-12-2021 7 0 Download
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The newly synthesized compounds were screened for their antimicrobial activities; some of them were found to be active towards the test microorganisms as the results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 31.3–500 µg/mL against gram-positive and gram-negative bacteria, Candia albicans and Saccharomyces cerevisiae.
12p langthannam 29-12-2021 8 0 Download
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Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR (1H, 13C) and HRMS spectrums.
9p tudichquannguyet 29-11-2021 9 1 Download
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Antimicrobial resistance (AMR) threatens millions of people around the world and has been declared a global risk by the World Economic Forum. One of the important AMR mechanisms in Enterobacteriaceae is the production of extended-spectrum β-lactamases. The most common ESBL, CTX-M β-lactamases, is spread to the world by CTX-M-15 and CTX-M-14. Sulbactam, clavulanic acid, and tazobactam are first-generation β-lactamase inhibitors and avibactam is a new non-β-lactam β-lactamase inhibitor.
12p tudichquannguyet 29-11-2021 6 1 Download
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The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated as a potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.
11p vibeauty 23-10-2021 13 0 Download
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Cryptocaryon irritans is an obligate parasitic ciliate protozoan that can infect various commercially important mariculture fish species and cause high lethality and economic loss. Current methods of controlling this parasite with chemicals or antibiotics are widely considered to be environmentally harmful. Piscidins with broad spectrum antibacterial, antifungal and antiviral activities were found to have potent activity against C. irritans. Little, however, has been understood about the killing mechanisms of piscidins in parasites.
11p vibeauty 23-10-2021 11 1 Download
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Bacillus subtilis strain NCD-2 is an excellent biocontrol agent against plant soil-borne diseases and shows broad-spectrum antifungal activities. This study aimed to explore some secondary metabolite biosynthetic gene clusters and related antimicrobial compounds in strain NCD-2.
16p vijeeni2711 30-06-2021 8 1 Download
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Five secondary metabolites including three flavonoids, 6-lavandulyl-5,7,2′,4′-tetrahydroxyflavanone (1), 5′- lavandulyl-2′-methoxy-2,4,4′,6′-tetrahydroxychalcone (2), 6-lavandulyl-7-methoxy-5,2′,4′-trihydroxyflavanone (3), and two alkaloids, tryptoline (4), and norharman (5) were isolated from the culture broth of Streptomyces sp. C011. Their structures were determined by spectral data analysis, including MS, 2D NMR, and CD spectrum. All the separated compounds were evaluated for their antimicrobial activities. Compounds 1, 2, 3 and 5 exhibited antimicrobial activity...
5p cothumenhmong11 06-05-2021 13 2 Download
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Community acquired pneumonia (CAP) is a major cause of morbidity, hospitalization, and mortality worldwide. Management of CAP for many patients requires rapid initiation of empirical antibiotic treatment, based on the spectrum of activity of available antimicrobial agents and evidence on local antibiotic resistance.
14p vimontana2711 05-04-2021 10 1 Download
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Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injuries but the source of posttraumatic HBD expression has not been focused on before.
9p vitennessee2711 02-02-2021 8 1 Download
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Antimicrobial spectrum of Escherichia coli isolated from poultry faecal samples in and around ranchi
Due to significance of E. coli infection in poultry, the present study was undertaken to isolate E. coli from faecal samples brought from various organized and backyard poultry farms situated in and around Ranchi and to study their antibiotic resistance pattern of widely available antibiotics.
5p trinhthamhodang9 16-12-2020 13 2 Download
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Beta-lactam antibiotics are the most commonly used antimicrobials against bacterial infections. In recent years, emergence of resistance to these antimicrobial agents due to production of β-lactamases has become a serious global health concern. It was reported as leading cause to ineffectiveness to antibiotic usage, increased morbidity and high cost of treatment. Extended spectrum beta-lactamases (ESBLs) detection amongst the Gram – negative bacilli is considered as an important marker of endemicity.
9p caygaocaolon8 07-11-2020 8 1 Download
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This retrospective study aims to analyze various uropathogens and their antimicrobial susceptibility pattern in a tertiary care hospital, which assist in selecting the most appropriate antibiotic therapy in treatment of Urinary Tract Infection.
8p cothumenhmong7 09-09-2020 11 1 Download