Antiviral effect

Flavonoids are a diverse group of natural compounds extensively studied in various research articles. They are widely distributed in the plant kingdom and exhibit various biological activities, including antioxidant, antiinflammatory, anticancer, antiviral, and antimicrobial effects. The genus Knema Lour., which contains many species in Southeast Asia, has been traditionally used to treat various ailments. The current review aims to provide a comprehensive update on the isolation of flavonoids and other secondary metabolites from the genus Knema Lour. between 1978 and 2022.

15p dianmotminh02 03-05-2024 5 2   Download

Ebola virus disease (EVD) is an often-fatal infection where the effectiveness of medical countermeasures is uncertain. During the West African outbreak (2013–2016), several patients were treated with different types of antiviral therapies including monoclonal antibody-based cocktails that had the potential to neutralise Ebola virus (EBOV). However, at the time, the efficacy of these therapies was uncertain.

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While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.

18p viellison 28-03-2024 1 1   Download

Although antiviral treatments have been shown to affect the recurrence and long-term survival of patients with hepatocellular carcinoma (HCC) who have high viral loads, the effect of different responses to antiviral therapy on the clinical outcomes remains unclear.

12p visharma 20-10-2023 5 2   Download

This work describes the electrochemical investigation of a promising antiviral agent, favipiravir (FAV) utilizing a nonmodified glassy carbon (GC) electrode, along with a unique voltammetric approach that can determine FAV with a good degree of accuracy, speed, and cost-effectiveness. Using cyclic voltammetry, the compound demonstrated a single well-defined and an irreversible oxidation peak at approximately +1.12 V (vs. Ag/AgCl) in Britton–Robinson (BR) buffer at pH 10.0.

12p lyhuyenthu 31-01-2023 5 2   Download

The CRISPR/Cas9 system has recently been engineered to confer resistance to geminiviruses in plants. However, we show here that the usefulness of this antiviral strategy is undermined by off-target effects identified by deep sequencing in Arabidopsis. We construct two virus-inducible CRISPR/Cas9 vectors that efficiently inhibit beet severe curly top virus (BSCTV) accumulation in both transient assays (Nicotiana benthamiana) and transgenic lines (Arabidopsis).

7p vigalileogalilei 27-02-2022 28 1   Download

Porcine reproductive and respiratory syndrome virus (PRRSV) is a serious viral disease of swine. At present, there are vaccines for the control of PRRSV infection, but the effect is not satisfactory. The recombination of attenuated vaccines causes significant difficulties with the prevention and control of PRRSV.

7p vigandhi 23-02-2022 14 1   Download

Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV) activities of baicalin in CEF cells.

9p vigandhi 23-02-2022 7 1   Download

Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention.

9p vigandhi 23-02-2022 14 1   Download

RNA-targeting CRISPR-Cas can provide potential advantages over DNA editing, such as avoiding pleiotropic effects of genome editing, providing precise spatiotemporal regulation, and expanded function including antiviral immunity.

24p viarchimedes 26-01-2022 8 0   Download

The effects of ionic strength and temperature on the dissociation constants of adefovir (PMEA) and cidofovir (HPMPC) used as antiviral drugs were studied at 298 K, 308 K, and 318 K in aqueous media and at different ionic strength backgrounds of NaCl potentiometrically. The dissociation constants of the ligands were determined via the calculation of the titration data with the SUPERQUAD computer program. The thermodynamic parameters (∆G, ∆H , and ∆S) for all species were calculated.

9p langthannam 29-12-2021 6 0   Download

A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)- (+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone. Spectroscopic results revealed that the Schiff bases containing camphor or carvone likely adopted an E-configuration along the characteristic imine bond while those containing camphorquinone assumed a Z-configuration.

43p tudichquannguyet 29-11-2021 7 2   Download

Essential oil (EO) dietary supplementation is a new strategy to improve animal health. EO compounds have antiparasitic, antimicrobial, antiviral, antimycotic, antioxidant and anti-inflammatory proprieties. Nutrigenomics investigations represent innovative approaches in understanding the relation between diet effect and gene expression related to the animal performance. Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses.

15p vibeauty 23-10-2021 10 1   Download

The aim of our work was to assess the effect of direct acting antivirals on portal hemodynamics by Doppler ultrasound in patients with post hepatitis C cirrhosis.

10p chauchaungayxua10 18-03-2021 6 1   Download

The use of natural feed additives as substitutes for antibiotic in poultry production has become an area of great interest. Medicinal plants or herbs consists of many pharmacologically active chemical compounds which have antimicrobial activity, antioxidant activity, antifungal activity, antiviral activity, anti-inflammatory effects as well as immunomodulatory properties (Toghyani et al., 2015).

7p angicungduoc8 07-11-2020 10 1   Download

India is endowed with an extensive network of fisheries resources; a long coast line of 1100 km along the Arabian Sea, supports a wide range of fish species with economic value and nutritional importance. Approximately 180 species of fish are found in fresh waters of India, majority of which are edible Antimicrobial proteins and peptides had been found from a wide variety of organisms in the last few years.

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Indigo alkaloids, such as indigo, indirubin and its derivatives, have been identified as effective antiviral compounds in Baphicacanthus cusia. Evidence suggests that the biosynthesis of indigo alkaloids in plants occurs via the shikimate pathway

11p viharuno2711 21-04-2020 5 2   Download

RNA interference (RNAi) is a specific and effective approach for inhibiting viral replication by introducing double-stranded (ds)RNA targeting the viral gene.

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The type I human interferon (IFN) family consists of a group of cytokines with a multiplicity of biological activities, including antiviral, antitumor, and immunomodulatory effects. However, because the half-life of IFN is short, its clinical application is limited.

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Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) whose wildlife reservoir is bats of the genus Pteropus. The emergence of pandemic potential of NiV is due to the fact that one or more pigs were infected from bats, and the virus then spread efficiently from pig to pig, then from pigs to people.

8p cothumenhmong3 22-02-2020 17 0   Download