Asthma severity
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Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases.
16p viellison 28-03-2024 2 2 Download
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The Asarum L. genus includes 128 species with many medicinal effects. It has been used extensively in folk prescriptions to treat several diseases such as bronchitis, asthma, rheumatism, and hepatitis. Many kinds of research showed that the Asarum L. species have many essential oils such as myristicin, methyl eugenol, myrcene, asafrol, borneol, safrol, or α-pinene, and substances such as sesquiterpenes, sterols, naringenin, or glycosyl flavonoids.
8p viberkshire 09-08-2023 5 2 Download
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Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population.
11p vinarcissa 21-03-2023 3 1 Download
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Considering the high incidence of equine asthma (> 14%) within horse population and the importance of this animal model for human disease, we aimed to investigate the metabolomic profile of bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) in healthy and asthmatic horses.
9p vigandhi 23-02-2022 14 1 Download
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Curcumin, a derivative of the spice turmeric, has been adopted by Eastern medicine for centuries as an adjunct to treat several medical conditions (e.g., anorexia and arthritis) because of its well-established antiinfammatory properties. Studies have shown that the use of curcumin in mice models has led to reduction in several inflammatory markers as well as key inflammatory pathway enzymes.
8p vimackenziebezos 29-11-2021 8 1 Download
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The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of diferent infammatory phenotypes among asthma patients in Jilin Province, China.
11p vimackenziebezos 29-11-2021 8 1 Download
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Research into the efects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms
8p vimackenziebezos 29-11-2021 10 1 Download
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The aim was to identify risk factors for severe adult-onset asthma. Methods: We used data from a population-based sample (Adult Asthma in Finland) of 1350 patients with adultonset asthma (age range 31–93 years) from Finnish national registers.
11p vimackenziebezos 29-11-2021 11 1 Download
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This paper investigates the issues of under-treatment and uncertainty condition of acute asthma cases in ED. A novel approach, known as the fuzzy logic principle is employed to determine the severity of acute asthma. The fuzzy set theory, known as Fuzzy Rule-based Expert System for Asthma Severity (FRESAS) determination is embedded into the expert system (ES) to assess the severity of asthma among patients in ED.
24p spiritedaway36 28-11-2021 12 1 Download
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Regions of the genome containing variants that influence the number of expressed RNA molecules are expression quantitative trait loci (eQTLs). Variation associated with RAO that also regulates a gene’s expression in a disease relevant tissue could help identify candidate genes that influence RAO if that gene’s expression is also associated with RAO disease status.
15p vitzuyu2711 29-09-2021 4 1 Download
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We read with interest the case presented by Sasada et al., describing the occurrence of aspergillosis in a patient who underwent bronchial thermoplasty (BT). Te isolation of Aspergillus fumigatus, the presence of elevated serum total IgE, and possible eosinophilic infammation (high FeNO) suggest allergic sensitization to A.fumigatus.
2p vijichoo2711 31-05-2021 10 1 Download
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Glucocorticoid has been used extensively in clinical applications, because of its several pharmacologic actions, which include immunosuppression, anti-inflammation, anti-shock, and relief of asthma.
7p viannito2711 20-04-2021 7 2 Download
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The recommendations for the treatment of moderate persistent asthma in the Global Initiative for Asthma (GINA) guidelines for paediatric asthma are mainly based on scientific evidence extrapolated from studies in adults or on consensus.
11p vianthony2711 16-04-2021 9 1 Download
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Bronchodilator response in patients with asthma is evaluated based on post-bronchodilator increase in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). However, the need for additional parameters, mainly among patients with severe asthma, has already been demonstrated.
6p vianthony2711 16-04-2021 12 1 Download
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Respiratory tract infections (RTIs) may be more severe in those with asthma or COPD and these patients are more frequently in need of health care. The aim of the study was to describe the frequency of RTI symptoms in a general adult population and how care-seeking is associated with the presence of obstructive lung disease.
9p vianthony2711 16-04-2021 15 1 Download
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Neuropeptide S Receptor 1 (NPSR1, GPRA, GPR154) was first identified as an asthma candidate gene through positional cloning and has since been replicated as an asthma and allergy susceptibility gene in several independent association studies.
13p vianthony2711 16-04-2021 10 2 Download
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Tachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics. These neuropeptides act mainly by their receptors NK1, NK2 and NK3, respectively which may be targets for new asthma therapy.
7p vianthony2711 16-04-2021 6 2 Download
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Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers. Using real-life situations this study was designed to evaluate asthma control in outpatients with moderate to severe persistent asthma and to compare efficacy of fixed combinations of inhaled corticosteroids (ICS) and long acting beta-agonists (LABA).
8p vianthony2711 16-04-2021 8 1 Download
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The morbidity associated with severe uncontrolled asthma is disproportionately higher in low- and middle-income countries than in high-income countries. The aim of this study was to describe the phenotypic characteristics of difficult-to-treat severe asthma and treatment-resistant severe asthma in a sample of children and adolescents in Brazil.
10p vimontana2711 05-04-2021 7 2 Download
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Asthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide setting in patients with uncontrolled asthma.
8p vimontana2711 05-04-2021 6 2 Download