Asymmetric methylation

Ebook "Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of α-Aryl ketones" addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

218p nhanphanguyet 28-01-2024 3 2   Download

RNA-directed DNA methylation (RdDM) initiates cytosine methylation in all contexts and maintains asymmetric CHH methylation. Mature plant embryos show one of the highest levels of CHH methylation, and it has been suggested that RdDM is responsible for this hypermethylation.

14p viarchimedes 26-01-2022 13 1   Download

Starting from a chiral secondary alcohol, novel enantiopure 1,4-aminoalkylphenols (AAPs) were prepared by exploiting conventional organic transformations such as the Mitsunobu reaction, Eschweiler–Clarke N -methylation, and demethylation of anisoles. The catalytic activity of the 1,4-AAPs was investigated in enantioselective Et2Zn addition to benzaldehyde. They were found to accelerate the Et2Zn addition to benzaldehyde. High yields and enantioselectivities (e.g., 95% yield and 82% ee) were achieved.

12p tudichquannguyet 29-11-2021 10 1   Download

DNA methylation is an important regulator of gene expression and chromatin structure. Methylated DNA immunoprecipitation sequencing (MeDIP-Seq) is commonly used to identify regions of DNA methylation in eukaryotic genomes. Within MeDIP-Seq libraries, methylated cytosines can be found in both double-stranded (symmetric) and single-stranded (asymmetric) genomic contexts.

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The methyl a-D-mannopyranoside molecule is bound in the Cl chair conformation 8.7 A from the calcium-binding site and 12.8 A from the transition metal-binding site. A network of seven hydrogen bonds connects oxygen atoms 0-3, 04, 0-5 and 0-6 of the mannoside to residues Asnl4, Leu99, TyrlO0, Asp208 and Arg228. 0-2 and 0-1 of the mannoside extend into the solvent. 0-2 is hydrogenbonded through a water molecule to an adjacent asymmetric unit.

5p byphasse043256 12-01-2019 19 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Atypical epigenetic mark in an atypical location: cytosine methylation at asymmetric (CNN) sites within the body of a non-repetitive tomato gene

11p panasonic02 14-12-2011 50 3   Download