Asymmetric synthesis

This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.

509p vimeyers 29-05-2024 5 2   Download

Nowadays, supercapacitors have been among popular electrochemical energy storage devices in modern life. Plenty of active materials have been investigated and developed to meet the increasing demands for high-performance supercapacitors. In this study, we introduce a facile chemical synthesis route in combination with a subsequent calcination process to fabricate the oxide/hydroxide composites of nickel (Ni) and copper (Cu) as active materials for highperformance asymmetric supercapacitors.

9p dianmotminh02 03-05-2024 3 1   Download

Ebook "Stereoselective desymmetrization methods in the assembly of complex natural molecules" describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date.

290p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Organic chemistry from retrosynthesis to asymmetric synthesis" connects a retrosynthetic or disconnection approach with synthetic methods in the preparation of target molecules from simple, achiral ones to complex, chiral structures in the optically pure form.

221p tracanhphuonghoa1007 22-04-2024 3 3   Download

Ebook "Progress in enantioselective Cu(I)-catalyzed formation of stereogenic centers" is not intended to provide a comprehensive review of all copper-catalysed reactions, but focuses on the most recent scientific advances in copper(I)-catalysed asymmetric synthesis. For this purpose, I have selected seven topics, most of which cover research conducted during the period 2010–2015. Several chapters deal with copper(I)-catalysed addition of organometallics to allylic substrates, β,β-disubstituted Michael acceptors and carbonyl groups.

229p tracanhphuonghoa1007 22-04-2024 4 3   Download

Ebook "Phosphorus chemistry I: Asymmetric synthesis and bioactive compounds" are dedicated to various topics in organophosphorus chemistry. The first volume concerns biologically-related topics (phosphinopeptides, phosphinic acids, prodrugs) as well as P-asymmetric compounds (also called P-stereogenic, P-chiral, etc. – there is still some intense discussion about how to name this field!).

250p tudohanhtau1006 29-03-2024 6 1   Download

Ebook "Stereoselective formation of amines (Topics in Current chemistry, Volume 343)" contains valuable and insightful contributions from several leading experts in this field, and the reviews within collectively provide an overview of a diverse set of valuable approaches as well as their implementation toward natural product and pharmaceutical synthesis.

292p tudohanhtau1006 29-03-2024 4 1   Download

Ebook "New organocatalytic strategies for the selective synthesis of centrally and axially chiral molecules" discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas. Organocatalysis is a relatively modern and “hot” topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism.

173p coduathanh1122 27-03-2024 4 1   Download

Ebook "Hydrolysis, oxidation and reduction (Catalysts for fine chemical synthesis, Volume 1)" to be a practical help for advanced undergraduate, graduate and postgraduate students, as well as experienced chemists in industry and academia working in organic and organometallic synthesis. The procedure section contains a wide variety of synthetic protocols, such as epoxidations of unsaturated ketones and esters, asymmetric reductions of carbon-oxygen double bonds, asymmetric hydrogenations of carbon-carbon double bonds and other types of reaction.

235p coduathanh1122 27-03-2024 5 1   Download

Ebook "Green approaches to asymmetric catalytic synthesis" summarizes the impressive amount of research that has been gathered within this field into three chapters focusing on: i) the search of alternative catalysts, ii) alternative solvents, and iii) alternative synthetic strategies and processes. For each topic, the fundamentals and some valuable applications are discussed.

150p manmanthanhla0201 26-02-2024 1 1   Download

Ebook "Hydroformylation for organic synthesis" should give a taste of the high level of refinement reached nowadays by hydroformylation. We present this “old” reaction to an audience of organic chemists who may or may not be conscious of its potential for synthesis of complex molecules. However, we are sure that those who are not aware of this potential will be convinced after reading these chapters.

233p nhanphanguyet 28-01-2024 2 2   Download

Ebook "Hydrofunctionalization (Topics in organometallic chemistry, Volume 43)" provides the broad scientific readership with a comprehensive summary and critical overview of a specific topic in organometallic chemistry. Research in this rapidly developing transdisciplinary field is having profound influence on other areas of scientific investigation, ranging from catalytic organic synthesis to biology, medicine and material science.

377p nhanphanguyet 28-01-2024 6 2   Download

Ebook "Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of α-Aryl ketones" addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

218p nhanphanguyet 28-01-2024 3 2   Download

We have effectively synthesized ZnS, FeSe2, and their nanocomposite using a straightforward and affordable solvothermal process. We also investigated for the first time their ideal electrochemical performance for supercapacitors.

10p viberbers 09-08-2023 8 3   Download

The asymmetric synthesis of α-(heteroaryl)alkylamines was accomplished by employing a diastereoselective nucleophilic 1,2-addition of lithiated aromatic heterocycles to aldehyde SAMP-hydrazones, followed by BH3·THF or SmI 2 promoted removal of the chiral auxiliary. The CBz or benzoyl-protected amines were obtained in good yields (40%–78%) and excellent enantiomeric excesses (ee = 88%–99%). The methodology can be applied to the synthesis of highly enantioenriched α-amino acids (ee = 90%–99%).

27p langthannam 29-12-2021 16 0   Download

This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N -heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.

24p langthannam 29-12-2021 15 0   Download

A series of asymmetrical substituted tetrahydropyrimidinium salts and different kinds of bridged bistetrahydropyrimidinium salts were prepared through the quaterization of tetrahydropyrimidine or the dehydrogenation of hexahydropyrimidine. They were characterized and used as NHC precursors in the palladium catalyzed Buchwald– Hartwig amination reaction.

9p langthannam 29-12-2021 6 0   Download

Three new asymmetrical photochromic diarylethenes containing a variable heteroaryl ring and a quinoline unit were synthesized and their structures were determined by single-crystal X-ray diffraction analysis. Their properties, including photochromism, acidichromism, and fluorescence, were investigated systematically. For these diarylethenes, the one with an indole moiety had the largest absorption maximum, cyclization quantum yield, photoconversion ratio, emission peak, and fluorescent modulation efficiency.

16p langthannam 29-12-2021 5 0   Download

Numerous efficient synthetic methodologies have been elaborated for the synthesis of β -blockers since the introduction of propranolol (a beta-blocker) in 1968. In this review, focus is placed on the more concise asymmetric and bioenzymatic synthetic approaches attempted towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol).

32p langthannam 29-12-2021 1 0   Download

Novel chiral bisoxazoline ligands based on norbornadiene were synthesized and used for the asymmetric Henry reaction. Various aromatic aldehydes were converted into chiral β -nitro alcohols with high yields and moderate to acceptable enantioselectivities under the optimized reaction conditions. The short and efficient synthesis of bisoxazoline ligands, the flexibility in ligand design, coordination to a large number of transition metals, and excellent enantioselectivity in many reactions make these ligands indispensable in asymmetric catalysis.

14p langthannam 29-12-2021 7 0   Download