Attractive potential treatment

Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the context of currently used cancer treatments.

18p viarchimedes 26-01-2022 9 0   Download

Activated carbon (AC), a porous material with high pore volume, attracts increasing attention owing to its potential applications in several fields. The development of a porous structure in AC marginally relies on both the treatment methods and the type of precursor. Thus far, both renewable and nonrenewable precursor sources have been used to synthesize AC with high surface area and pore volume. This study presents the synthesis of AC via physicochemical treatment of waste oil fly ash (OFA), a waste material produced from power plants.

17p tudichquannguyet 29-11-2021 6 1   Download

Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to the angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) are an attractive potential treatment.

5p vichaeng2711 29-04-2021 26 1   Download

Identifying the predictors of noninvasive ventilation (NIV) failure has attracted significant interest because of the strong link between failure and poor outcomes. However, very little attention has been paid to the timing of the failure.

10p vimontana2711 05-04-2021 18 1   Download

ESR1 mutations have attracted attention as a potentially important marker and treatment target in endocrine therapy-resistant breast cancer patients. The E380Q mutation, which is one of the ESR1 mutations, is associated with estradiol (E2) hypersensitivity, increased DNA binding to the estrogen response element, and E2-independent constitutive trans-activation activity, but its frequency in ESR1 mutations remains unknown.

9p vimanama2711 30-07-2020 10 2   Download

Lonicera japonica Thunb. flower has been used for the treatment of various diseases for a long time and attracted many studies on its potential effects. Transcription factors (TFs) regulate extensive biological processes during plant development.

19p vishikamaru2711 25-04-2020 24 1   Download

Chagas disease, which is caused by Trypanosoma cruzi, is a major health problem in Latin America, and there are currently no drugs for the effective treatment of this disease. The energy metabolism of T. cruzi is an attractive target for drug design, and we previously reported that inhibitors of α-hydroxy acid dehydrogenase (HADH)-isozyme II exhibit trypanocidal activity.

13p vienzym2711 03-04-2020 12 2   Download

Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of cancer, diabetes and other human diseases. HDAC inhibitors, as a new class of potential therapeutic agents, have attracted a great deal of interest for both research and clinical applications. Increasing efforts have been focused on the discovery of HDAC inhibitors and some HDAC inhibitors have been approved for use in cancer therapy.

14p vienzym2711 30-03-2020 7 2   Download

The Chinese citrus fruit ßy, Bactrocera minax (Enderlein) is a univoltine Tephritidae pest that infests Citrus species. Field trials were conducted in 2010 to determine the potential use of a lure based on enzymatical-hydrolyzed beer yeast as liquid bait (hereafter named H-protein bait) for B. minax in the Hubei province, China.

9p caygaocaolon2 11-03-2020 11 0   Download

Guava is an important fruit of India, rich in minerals and vitamin C. Fruit flies are one of the most noxious pest of guava which can cause tremendous loss to farmers due to its infestation.

11p nguathienthan2 25-12-2019 28 1   Download

Chronic hepatitis C virus (HCV) infection is a systemic disease that leads to increased risks of cirrhosis and its complications, as well as extrahepatic disturbances, including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk, and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms (in)directly linking HCV infection to vascular damage.

8p kequaidan1 16-11-2019 12 0   Download

Current popular cancer treatment options, include tumor surgery, chemotherapy, and hormonal treatment. These treatments are often associated with some inherent limitations. For instances, tumor surgery is not effective in mitigating metastases; the anticancer drugs used for chemotherapy can quickly spread throughout the body and is ineffective in killing metastatic cancer cells. Therefore, several drug delivery systems (DDS) have been developed to target tumor cells, and release active biomolecule at specific site to eliminate the side effects of anticancer drugs.

15p caygaocaolon1 13-11-2019 17 0   Download

Recent strategies for the treatment of cancer, other than just tumor cell killing have been under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis inhibition is an important strategy for the treatment of solid tumors, which basically depends on cutting off the blood supply to tumor micro-regions, resulting in pan-hypoxia and pan-necrosis within solid tumor tissues. The differential activation of angiogenesis between normal and tumor tissues makes this process an attractive strategic target for anti-tumor drug discovery.

15p caygaocaolon1 13-11-2019 20 0   Download

Ultimately the aim would be for adequate long term funding being available to refugee and asylum seekers self-help, community and voluntary sector organisations in order for them to deliver local services to local communities. Treatment and service options would therefore be more easily controlled and chosen in accordance with the context of refugee and asylum seekers lives and therefore the actual needs and choices of the individual.

0p commentcmnr 03-06-2013 94 9   Download

Private investors can be valuable and innovative partners in maintaining and modernizing critical infrastructure. Our current system of financing, however, has often failed in its attempts to forge viable partnerships with private investors. While the traditional American method of attracting private capital by offer- ing tax-exempt municipal bonds has been successful in many instances and will remain a valuable tool for infrastructure investment, it often leaves many large potential investors sitting on the sidelines.

42p enterroi 02-02-2013 49 4   Download

A put option contract gives its holder the right to sell a specified number of shares of the underlying stock at the given strike price on or before the expiration date of the contract. I. Buying puts to participate in downward price movements. Put options may provide a more attractive method than shorting stock for profiting on stock price declines, in that, with purchased puts, you have a known and predetermined risk. The most you can lose is the cost of the option. If you short stock, the potential loss, in the event of a price upturn, is unlimited.

20p quaivattim 04-12-2012 36 1   Download

The core list presents a list of minimum medicine needs for a basic health‐care system, listing the most efficacious, safe and cost‐effective medicines for priority conditions. Priority conditions are selected on the basis of current and estimated future public health relevance, and potential for safe and cost‐effective treatment. The complementary list presents essential medicines for priority diseases, for which specialized diagnostic or monitoring facilities, and/or specialist medical care, and/or specialist training are needed.

45p kikyou751998 23-05-2012 439 37   Download

This information is not presented by a medical practitioner and is for educational and informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read.

69p tienwru 13-09-2010 106 38   Download