Augmented renal clearance

In ICU patients, glomerular filtration is often impaired, but also supraphysiological values are observed (“augmented renal clearance”, >130 mL/min/1.73 m2 ). Renally eliminated drugs (e.g. many antibiotics) must be adjusted accordingly, which requires a quantitative measure of renal function throughout all the range of clinically encountered values.

8p viisaacnewton 25-04-2022 11 1   Download

Administration of vancomycin in critically ill patients needs close regulation. While subtherapeutical vancomycin serum concentration (VSC) is associated with increased mortality, accumulation is responsible for nephrotoxicity. Our study aimed to estimate the efficacy of a vancomycin-dosing protocol in reaching appropriate serum concentration in patients with and without kidney dysfunction.

7p viisaacnewton 25-04-2022 9 1   Download

This study aimed to estimate PKparameters of imipenem and those potential covariates. Methods: Burn patients with body surface area injured >20% andimipenem indicationwere recruited. Two set of plasma samples (30 min post-dose and 1-2 hours before next dose)were obtainedat imipeneminitiation and before the end of imipenem use. ARC was defined if 8h-urinary creatinine clearance (8hClcr) was above 130 mL.min1173 m2.

13p thithizone4 31-07-2019 18 1   Download