Autoimmune hepatitis

PD-1 is an immunoinhibitory receptor which plays vital role in pathogenesis of hepatitis B virus (HBV) infection. The aim of this study was to understand the relationship between PD-1.1 polymorphism in HBV infection and liver disease progression.

6p vilarry 12-03-2024 4 2   Download

Autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome is a form of autoimmune hepatitis with cholestatic features and is characterized by negative anti-mitochondrial antibody and cholangiographic changes on magnetic resonance cholangiopancreatography or endoscopic retrograde cholangiopancreatography.

5p vilazada 31-01-2024 4 2   Download

Pregnancy after liver transplantation poses a significant challenge to both the patient and the transplant team. We present the case of a 19-year-old European patient who underwent liver transplantation 5 years previously owing to autoimmune hepatitis.

9p vitiki 30-01-2024 2 2   Download

Hepatocellular carcinoma (HCC) is a primary tumor of the liver. The majority of HCCs are associated most frequently with chronic B or C viral hepatitis, alcohol intake or aflatoxin exposure. Cirrhosis is a strong risk factor associated with HCC.

8p vitiki 30-01-2024 9 2   Download

Part 2 book "Comparative hepatitis" includes content: Comparative hepatitis - Diseases caused by adult parasites or their distinct life cycle stages, autoimmune hepatitis in humans, hepatitis in dogs, hepatitis in horses, the woodchuck model of hepadnavirus infection, hepadnaviruses have a narrow host range — do they, the liver as immune escape site for pathogens, drug candidates for the treatment of viral hepatitis.

219p muasambanhan01 13-12-2023 3 1   Download

Primary biliary cholangitis (PBC) is a chronic, autoimmune cholestatic disease, characterized by inflammation of the small and mediumsized bile ducts, which can lead to cirrhosis. Two to nineteen percent of patients with PBC have been reported to have features that overlap with autoimmune hepatitis (AIH).

3p viintuit 26-09-2023 4 0   Download

Vanishing bile duct syndrome (VBDS) is an acquired syndrome characterized by clinical and laboratory signs of cholestasis with pathologic findings of interlobular bile duct paucity in liver biopsy specimens. VBDS can result from a variety of conditions including infections, autoimmune diseases, adverse drug reactions, and neoplastic processes.

7p viwhitewolf 03-07-2023 5 2   Download

There is ample evidence indicating that immunosuppressive therapy or immune dysregulation in systemic lupus erythematosus increases the risk for tuberculosis. Interestingly, a few case reports suggest that tuberculosis could also be a risk factor for systemic lupus erythematosus and other autoimmune diseases.

6p vigamora 23-05-2023 5 2   Download

Overlap syndrome between primary biliary cholangitis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only few published cases so far in the literature. We highlight here the rarity of this condition and indicate the importance of its recognition.

5p vidoctorstrange 06-05-2023 5 2   Download

Despite extensive research the genetic component of extremely low birth weight (ELBW) in newborns has remained obscure. A family of four was studied: mother, father and two ELBW-phenotype children. Studies were made of the medical conditions of the second child at birth and post-partum - peculiar phenotype, micro-anomalies, recurrent infections, suspicion of autoimmune hepatitis, multifactorial encephalopathy and suspected metabolic and chromosomal abnormalities.

5p vinarcissa 21-03-2023 6 1   Download

End stage liver disease (ESLD) is associated with significant thrombotic complications. In this study, we attempted to determine if patients with ESLD, due to oncologic or autoimmune diseases, are susceptible to thrombosis to a greater extent than patients with ESLD due to other causes.

7p viisaacnewton 25-04-2022 18 1   Download

Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases.

4p vimaine2711 26-03-2021 10 2   Download

The incidence of bilateral corticosteroid-induced osteonecrosis of the femoral head (ONFH) is high. Although the precise mechanism of corticosteroid-induced ONFH development is unclear, hepatic enzyme abnormalities such as low activity of hepatic cytochrome P450 3A could be one cause.

4p vivermont2711 28-01-2021 9 2   Download

Since its discovery in 1989, hepatitis C virus (HCV) infection has become a major cause of chronic liver disease worldwide with 14.7% prevalence in Egypt. There is increasing body of evidence that chronic HCV infection is usually associated with several extrahepatic manifestations. Several studies have shed light on the association of autoimmune thyroiditis (ATD) and type 1 diabetes (T1D) with chronic HCV infection as both are considered to be one of the most common organ specific autoimmune disease frequently occur together.

10p angicungduoc8 07-11-2020 11 1   Download

The revolution of Epigenetics mechanisms including mi-RNA, DNA methylation and histone modification has drawn our attention to target Th17 cell regulatory cytokines and transcription factors which in turn will inhibit the production of interleukin 17 (IL17)- as it’s the key proinflammatory cytokine secreted by TH17 cells.

7p nguathienthan8 20-10-2020 12 2   Download

Pembrolizumab is an anti- Programmed Death 1 (PD-1) antibody approved in melanoma, non-small cell lung cancer and investigated in malignant pleural mesothelioma. The most frequent immunotherapy related autoimmune reactions include dermatitis, pneumonitis, colitis, hypophysitis, uveitis, hypothyreodism, hepatitis and interstitial nephritis.

3p vimale2711 25-08-2020 7 1   Download

Autoimmune endocrine disorders are considered one of the extrahepatic manifestations of Hepatitis C virus (HCV) infection. HCV could trigger cytokines release due to local inflammation. Interleukin 17 a (IL17a) and Interferon gamma (IFNγ) play an important role in pathogenesis of autoimmune disease. Herein, we tried to assess the serum levels of IL17a and IFN-gamma in cirrhotic HCV infected patients with autoimmune thyroiditis. Serum samples were collected from 183 cirrhotic HCV infected patients.

12p kethamoi6 29-06-2020 20 1   Download

Turmeric is a popular herbal dietary supplement that has been considered safe and even shown to have hepatoprotective properties. In the recent times, however, there have been a few case reports of turmeric-induced liver injury. We report a 55-year-old woman with chronic turmeric consumption whose initial diagnosis was acute autoimmune hepatitis. She declined steroid treatment, and hence, we recommended discontinuing her long-term turmeric usage. A month after discontinuation, her liver function returned to normal.

4p covid19 11-05-2020 17 1   Download

Cholestatic hepatitis has not been reported as a paraneoplastic syndrome of endometrial adenocarcinoma to our knowledge. We present a patient who, shortly after endometrial adenocarcinoma diagnosis, presented with elevated liver chemistries in the setting of an acute, paraneoplastic sensorimotor polyneuropathy. Infectious, autoimmune, pharmacologic, malignant, metabolic, and structural causes of cholestatic hepatitis were screened for and ruled out.

3p covid19 11-05-2020 30 0   Download

Hepatitis C virus (HCV) infected patients are known to be exposed to major liver complications i.e. cirrhosis and hepatocellular carcinoma. In addition, many extrahepatic manifestations including rheumatologic disorders have been reported in up to two-third of HCV infected patients. These manifestations include frank auto-immune and rheumatic diseases (such as arthralgia, myalgia, arthritis, sicca syndrome and vasculitis) which may dominate the course of infection.

9p kequaidan1 16-11-2019 14 0   Download