Autoinhibitory

Myeloid ecotropic insertion site (Meis)2 is a homeodomain protein contain-ing a conserved homothorax (Hth) domain that is present in all Meis and Prep family proteins and in theDrosophilaHth protein. The Hth domain mediates interaction with Pbx homeodomain proteins, allowing for efficient DNA binding.

14p mobifone23 21-01-2013 30 4   Download

The etiology of PV is unknown. Although nonrandom chromosome abnormalities such as 20q, trisomy 8, and especially 9p, have been documented in up to 30% of untreated PV patients, unlike CML no consistent cytogenetic abnormality has been associated with the disorder. However, a mutation in the autoinhibitory, pseudokinase domain of the tyrosine kinase JAK2—which replaces valine with phenylalanine (V617F), causing constitutive activation of the kinase— appears to have a central role in the pathogenesis of PV.

5p thanhongan 07-12-2010 71 4   Download