B cell maturation antigen
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B cell maturation antigen (BCMA) targeted immunotherapies have demonstrated remarkable clinical efficacy in multiple myeloma (MM). Here, we evaluated the BCMA expression in MM and other plasma cell dyscrasias (PCDs), hoping to provide a potential treatment strategy for the relapsed/refractory PCDs besides MM.
9p vischultz 20-10-2023 1 1 Download
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B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor (BCR) genes and selection by their ability to bind antigens.
11p vijeeni2711 30-06-2021 12 1 Download
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Somatic hypermutation promotes affinity maturation of antibodies by targeting the cytidine deaminase AID to antibody genes, followed by antigen-based selection of matured antibodies.
13p vihamax2711 21-04-2020 12 1 Download
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Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) that affect prime naive T cells and create proper immune responses. The uncontrolled growth of cancer cells often results from the cell’s successful inhibition of cytotoxic T lymphocytes. In addition to conventional cancer treatments, including surgery, chemotherapy, and radiation therapy, immunotherapies have been seen to offer promising and innovative cancer treatments. Currently, DC therapy is one of the most popular immunotherapies because it uses tumour antigen-pulsed DC vaccines to fight against cancers.
5p caygaocaolon1 13-11-2019 10 0 Download
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IL-10 is an anti-inflammatory cytokine, participating in induction of immune tolerance and cell apoptotic death. Dendritic cells (DCs) is the most professional antigen-presenting cells among innate immune cells to exert generation and maintenance of immunological memory mediated through activation of T and B lymphocytes. The STAT signalling pathway plays a regulatory role of maturation and differentiation of immune cells.
8p gaunguyen6789 22-10-2019 8 0 Download
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Antigen binding to the B-cell receptor (BCR) of pre-mature B lymphocytes induces their apoptotic cell death, but binding to the BCR of mature B lymphocytes triggers activation and proliferation. Binding to pre-mature B lymphocytes is thought not only to function as a mechanism to exclude B-cell clones that possess the ability to react with self-antigen, but also to act as a defense mechanism in auto-immune diseases.
20p vinaphone15 27-02-2013 33 1 Download
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In summary, the DLEU2/miR-15a/16-1 tumor suppressor locus plays a role in regulating the expansion of the mature B-cell pool, by preventing the entry into G0/G1-S transition. The impairment of this cell cycle control in MDR-deleted cells may allow them to proliferate after BCR stimulation by foreign or self antigens. In these conditions, a model for the pathogenesis of CLL with 13q14 deletion based on the presumptive cellular origin of the tumor cell precursor can be proposed.
412p wawawawawa 26-07-2012 46 5 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin...
14p thulanh14 19-10-2011 41 3 Download