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BAF complex
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Open chromatin regions are correlated with active regulatory elements in development and are dysregulated in diseases. The BAF (SWI/SNF) complex is essential for development, and has been demonstrated to remodel reconstituted chromatin in vitro and to control the accessibility of a few individual regions in vivo.
17p
viaristotle
29-01-2022
14
0
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An intricate gene regulatory network drives neural crest migration and differentiation. How epigenetic regulators contribute to this process is just starting to be understood.
11p
viwyoming2711
16-12-2020
11
1
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Lamins are major structural components of the nuclear envelope in multi-cellular eukaryotes. Particularly A-type lamins are also located in the nucleoplasm, likely involving a specific binding partner, lamina-associated polypeptide 2a (LAP2a). LAP2a–lamins A⁄C complexes in the nucleo-plasm have been implicated in the regulation of gene expression by various means.
12p
galaxyss3
21-03-2013
34
2
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The SWI⁄SNF chromatin remodelling complexes are important regulators of transcription; they consist of large multisubunit assemblies containing either Brm or Brg1 as the catalytic ATPase subunit and a variable subset of approximately 10 Brg⁄Brm-associated factors (BAF). Among these factors, BAF60 proteins (BAF60a, BAF60b or BAF60c), which are found in most complexes, are thought to bridge interactions between transcription factors and SWI⁄SNF complexes.
12p
mobifone23
18-01-2013
23
2
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