Benzimidazole resistance

The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast cancer.

12p vialfrednobel 23-12-2023 4 3   Download

Infections of small ruminants with trichostrongyloid nematodes often result in reduced productivity and may be detrimental to the host. Anthelmintic resistance (AR) against most anthelmintic drug classes is now widespread amongst the trichostrongyloids.

9p vigalileogalilei 28-02-2022 13 1   Download

The aim of this study was to determine the prevalence of AR to benzimidazoles (BZ), macrocyclic lactones (ML) and imidazothiazoles represented by levamisole (LEV) in the Polish goat herds by using an in vitro larval development test, which is useful especially in large-scale epidemiological surveys.

12p vidarwin 23-02-2022 9 1   Download

Prophylactic anthelmintic treatment with one of three basic classes of anthelmintics (benzimidazoles, macrocyclic lactones and imidazothiazoles) is still the mainstay of control of gastrointestinal nematode infections in small ruminants worldwide. As a consequence, anthelmintic resistance is a serious threat to small ruminant health and production.

12p vigandhi 23-02-2022 14 1   Download

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13–22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1,4–12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillinresistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.

5p langthannam 29-12-2021 8 0   Download

The present study was planned to know the status of anthelmintic resistance in gastrointestinal (GI) nematodes of two organized sheep and one goat farms of subHimalayan region of northern India using faecal egg count reduction test (FECRT). Three anthelmintics, fenbendazole (FBZ), tetramisole HCl (TMS) and ivermectin (IVM) of benzimidazole, imidazothiazole and macrocyclic lactone groups, respectively were tested at each farm.

7p gaocaolon9 22-12-2020 11 1   Download

This study aimed to evaluate the anthelmintic resistance (AR) for gastrointestinal nematodes from naturally infected cattle in Assam to several commercially available anthelmintics like fenbendazole, albendazole and levamisole.

6p caygaocaolon7 18-09-2020 11 1   Download

Priming is a valuable, facile and well-established technique used to enhance seed quality to achieve rapid germination, establishment of stress resistance and improvement of crop yields.

11p vijiraiya2711 27-05-2020 6 1   Download

The mechanism of benzimidazoles resistance is linked to single nucleotide polymorphisms (SNPs) on beta-tubulin isotype-1 gene. The three known SNPs responsible for BZ resistance are F200Y, F167Y and E198A on the beta-tubulin isotype-1. The present study was aimed to characterize beta-tubulin isotype-1 gene of Bunostomum trigonocephalum, for identifying variations on possible mutation sites. The adult parasites were collected from Mukteswar, Uttarakhand. The parasites were thoroughly examined morphologically and male parasites were subjected for RNA isolation.

8p trinhthamhodang5 16-05-2020 12 1   Download

Anthelmintic drug resistant rising the major threat for the animal population. Benzimidazole group of anthelmintic drug are most popular and used drug in nematodal control strategy. High treatment frequency, single-drug regimens, targeting the mass treatments, under-dosing, improper use of anthelmintic, improper management, unguided and unaddressed policy of nematodal control leads to the resistant among the animal population which become main source of transferring and migrating the resistant to another. Selection pressure act majorly in escaping the treatment.

14p kethamoi4 16-04-2020 13 0   Download

Benzimidazole resistance (BZR) is known to be associated with single nucleotide polymorphisms (SNPs) on beta-tubulin isotype 1 gene at any of F200Y, F167Y and E198A positions. Characterization of beta-tubulin isotype 1 gene is prerequisite for designing molecular diagnostic method for ascertaining BZR at the early stage of development. Present study was designed to characterize beta tubulin isotype-1 gene of Trichostrongylus colubriformis of small ruminants.

9p trinhthamhodang1212 06-04-2020 17 1   Download

Parasitic diseases rank among the most prevalent infectious diseases. Chemotherapy forms the mainstay for control of parasites. Availability of antiparasitic drugs is limited due to high cost of development of newer drugs and rapid pace of development of resistance.

13p chauchaungayxua4 22-03-2020 14 1   Download