Biliary excretion

Part 1 book "Comparative pharmacokinetics - Principles, techniques and applications" includes content: Introduction, principles of drug movement in the body, principles of drug movement in the body, absorption, distribution, renal elimination, hepatic biotransformation and biliary excretion, compartmental models, noncompartmental models.

208p oursky05 20-09-2023 5 1   Download

Idiopathic or transient neonatal cholestasis (TNC) represents a group of cholestatic disorders with unidentified origin and remains a diagnosis of exclusion. Dysfunction of hepatobiliary transporters mediating excretion of biliary constituents from hepatocytes may play a central role in the pathogenesis of cholestasis.

5p vimanama2711 28-07-2020 12 2   Download

The physiologically based pharmacokinetic (PBPK) model for liver transporter substrates has been established previously and used for predicting drug–drug interactions (DDI) and for clinical practice guidance. So far, nearly all the published PBPK models for liver transporter substrates have one or more hepatic clearance processes (i.e., active uptake, passive diffusion, metabolism, and biliary excretion) estimated by fitting observed systemic data.

11p caothientrangnguyen 09-05-2020 18 0   Download

However, cellular uptake of aglycones has been suggested to occur in their native form by passive diffusion. Absorbed polyphenols can directly undergo phase II metabolism as phenolic structures are generally unfavorable substrates to the cytochrome P450s (phase I metabolism). At nutritional doses, almost all polyphenols are conjugated to form O- glucuronides, sulfate esters and O-methyl ethers, by glucuronidation, sulfation and methylation, in the gut mucosa and later in the liver or kidney.

402p wqwqwqwqwq 23-07-2012 90 8   Download