Bio-analytical method

Ebook "Standardization and quality assurance in fluorescence measurements I: Techniques" is still in its infancy as compared to other prominent analytical and bioanalytical methods. Appropriate quality assurance standards are however a prerequisite for applications in highly regulated fields such as medical diagnostics, drug development, or food analysis. For the first time, a team of recognized international experts has documented the present status of quality assurance in fluorescence measurements, and outlines concepts for establishing standards in this field.

499p manmanthanhla0201 27-02-2024 4 1   Download

Ebook "Standardization and quality assurance in fluorescence measurements II: Bioanalytical and biomedical applications" is still in its infancy as compared to other prominent analytical and bioanalytical methods. Appropriate quality assurance standards are however a prerequisite for applications in highly regulated fields such as medical diagnostics, drug development, or food analysis. This second of two volumes covers applications of fluorescence for bioanalysis and biomedical diagnostics.

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The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid (1) and 2-(2,6-dibromo-3,5- dihydroxyphenyl)acetic acid (2) and as well as their derivatives 25 and 26 were carried out by substitution, hydrolysis and demethylation reactions of the corresponding four benzyl bromides. The antioxidant potentials of benzylic acid-derived bromophenols were, for the first time, appraised by several outstanding bioanalytical methods.

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This work is dealing with the use of polystyrene (PS) nanoparticles as substrates for bioanalytical specific interactions. Different techniques were used for the accurate characterization of the PS nanoparticles of 100 nm and 196 nm before coating them with a layer of antibodies against immunoglobulins of type E (aIgE).

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The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of ‘organ-on-a-chip’ systems. Organon-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development.

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We report herein the first synthesis of biologically active natural bromophenols, namely 1-(2,3,6-tribromo4,5-dihydroxybenzyl)pyrrolidin-2-one (2), 2RS-1-(2,3-dibromo-4,5-dihydroxybenzyl)-5-oxopyrrolidine-2-carboxylic acid (3), and 2RS-methyl 1-(2,3-dibromo-4,5-dihydroxybenzyl)-5-oxopyrrolidine-2-carboxylate (4), along with their different derivatives (6 and 8–18). Among the synthesized compounds, 3, 4, and their derivatives (8 and 9) are yielded in racemic form.

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5-Hydroxytryptamine (also known as 5-HT, serotonin) is one of the monoamine neurotransmitters which is distributed widely in plasma and brain of mammals and plays important roles in physiological manipulations.

9p vijiraiya2711 27-05-2020 6 1   Download

To formulate a nanoformulation (PLGA-NPs) and to improve brain bioavailability for thymoquinone (THQ) through intranasal (i.n.) drug delivery, using a newly UHPLC-PDA developed the method and validated. Five different THQ-PLGA-NPs (THQ-N1 to THQ-N5) were prepared by emulsion solvent evaporation method.

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Gender-based pharmacokinetics and/or pharmacodynamics differences can result in differences in treatment which can accordingly affect the drug safety and/or efficacy. A new validated bio-analytical LC-MS/ MS method was developed for the estimation of ezogabine, a third-generation antiepileptic drug, in human plasma using oxcarbazepine as an internal standard (IS) and to study the gender effect on the pharmacokinetic parameters in Egyptian human subjects.

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Biosystems and Biomaterials Division. The primary objective is to collaborate with or conduct research consistent with division projects in standards, measurement methods, and theoretical models that improve understanding and prediction of complex biological processes associated with environmental health, human health, and cell-based manufacturing.

130p thamgiacongdong 02-05-2013 38 5   Download