Bio-transformation

Part 1 book "Basic and clinical pharmacology" includes contents: Introduction - The nature of drugs and drug development and regulation, drug receptors and pharmacodynamics, pharmacokinetics and pharmacodynamics - rational dosing and the time course of drug action, drug biotransformation, pharmacogenomics, introduction to autonomic pharmacology; cholinoceptor activating and cholinesterase inhibiting drugs; cholinoceptor blocking drugs; adrenoceptor agonists and sympathomimetic drugs, adrenoceptor antagonist drugs,... and other contents.

502p dianmotminh01 17-05-2024 3 3   Download

Ebook "Biotransformations in organic chemistry: A textbook (7th edition)" have been introduced which include alcohol and amine oxidases, amine dehydrogenases, imine reductases, haloalkane dehalogenases, ATP-independent phosphorylation, Michael-additions and cascade reactions. This new edition also emphasizes the use of enzymes in industrial biotransformations with practical examples.

442p tracanhphuonghoa1007 22-04-2024 3 2   Download

Ebook "Pyrethroids: From chrysanthemum to modern industrial insecticide" includes chapters on the progress and the future of pyrethroids, the biosynthesis of natural pyrethrins, newly developed polyfluorobenzyl-type pyrethroids with potent insecticidal activity, the mode of action, mammal toxicology, biotransformation and enzymatic reactions, environmental behavior, and ecotoxicology of pyrethroids.

233p coduathanh1122 27-03-2024 3 1   Download

Part 1 book "Casarett and Doull's toxicology - The basic science of poisons" includes content: History and scope of toxicology; principles of toxicology; mechanisms of toxicity; risk assessment; absorption, distribution, and excretion of toxicants; biotransformation of xenobiotics; toxicokinetics8. chemical carcinogenesis; genetic toxicology; developmental toxicology11. toxic responses of the blood; toxic responses of the immune system; toxic responses of the liver; toxic responses of the kidney; toxic responses of the respiratory system.

751p muasambanhan01 11-12-2023 3 2   Download

Part 1 book "Introduction to food toxicology" includes content: Principles of toxicology; determination of toxicants in foods; biotransformation; chemical carcinogenesis; natural toxins in animal foodstuffs; toxic phytochemicals.

169p oursky10 07-12-2023 5 2   Download

Part 1 book "The toxicology of fishes" includes content: Introduction, bioavailability of chemical contaminants in aquatic systems, toxicokinetics in fishes, biotransformation in fishes, receptor mediated mechanisms of toxicity, reactive oxygen species and oxidative stress, liver toxicity, the osmoregulatory system, toxic responses of the fish nervous system

476p oursky08 02-11-2023 5 2   Download

Part 1 book "Comparative pharmacokinetics - Principles, techniques and applications" includes content: Introduction, principles of drug movement in the body, principles of drug movement in the body, absorption, distribution, renal elimination, hepatic biotransformation and biliary excretion, compartmental models, noncompartmental models.

208p oursky05 20-09-2023 5 1   Download

Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxifcation of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine kinase inhibitors.

11p viangelamerkel 27-07-2022 4 2   Download

Gluconobacter oxydans is a strictly aerobic Gram-negative acetic acid bacterium used industrially for oxidative biotransformations due to its exceptional type of catabolism. It incompletely oxidizes a wide variety of carbohydrates regio- and stereoselectively in the periplasm using membrane-bound dehydrogenases with accumulation of the products in the medium.

17p vitzuyu2711 29-09-2021 11 1   Download

In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human physiology.

12p visilicon2711 20-08-2021 10 0   Download

Xylose reductase (XR) is responsible for biotransformation of xylose to xylitol and it has gained significant position amongst industrial enzymes due to its role in meeting the demand of xylitol by utilizing agriculture waste. Xylitol is a rare pentose sugar alcohol having a number of therapeutic and pharmaceutical applications. There is a paradigm shift for biotechnological production of xylitol over conventional chemical method.

16p angicungduoc8 07-11-2020 10 1   Download

Neonicotinoid insecticides are widely used nowadays to control many sucking insect-pests in several horticultural crops. They are neurotoxic and systemic in nature and their indiscriminate use may affect both target as well as beneficial insects. They are persistent insecticides and can enter food chain through soil application because of high water solubility. Microbes play an important role in removing toxic insecticides from soil environment and microbial degradation can be considered to be a cost effective mechanism to detoxify the insecticides.

23p kethamoi7 26-08-2020 16 2   Download

Oil rich effluents are always a menance for many industries in the process of effluent treatment. The process usually requires more complex methods to resolve the issue to reach to disposable effluent standards. Enzymatic degradation was proved to be promising for the efficient treatment of oil rich effluents. Among the hydrolytic enzymes, lipases are the second most widely-used enzymes in industrial applications. A potential lipolytic fungus obtained from a marine soil sample exposed to oil spillage was identified as Aspergillus japonicus MF-1.

16p angicungduoc6 20-07-2020 11 1   Download

The present study explores the bioconversion by Geotrichum candidum of five amino acids to their corresponding α-keto acids used in the treatment of chronic kidney disorder. The amino acid oxidase activity biotransforming amino acids to α-keto acids was detected in biomass as well as extracellular culture fluids of G. candidum. Bioconversion was determined by measuring α-keto acid production along with residual amino acid. There was a 2-fold increase in the amount of α-keto acids produced over a period of 24 hours by permeabilization of biomass when compared to immobilized biomass.

9p nguaconbaynhay6 24-06-2020 7 1   Download

The objective of the work was to characterize fungal endophytes from aerial parts of Vanilla planifolia. Also, to establish their biotransformation abilities of flavor-related metabolites. This was done in order to find a potential role of endophytes on vanilla flavors.

19p vihashirama2711 21-05-2020 16 1   Download

Fexofenadine is an important medicament having significant antihistaminic activity. It is currently being prepared by chemical route which is in numerous stages of development with a yield of less than 10%. In this study, bio-transformation of terfenadine to fexofenadine was investigated using few microbial strains. Among the microbes studied, Absidia corymbifera ATCC14058 showed the highest conversion efficiency in a base line study.

8p trinhthamhodang5 16-05-2020 15 2   Download

L-arabinose isomerase (AI) is a crucial catalyst for the biotransformation of D-galactose to D-tagatose. In previous reports, AIs from thermophilic bacterial strains had been wildly researched, but the browning reaction and by-products formed at high temperatures restricted their applications.

11p viuchiha2711 21-04-2020 13 1   Download

β-D-xylosidase is a vital exoglycosidase with the ability to hydrolyze xylooligosaccharides to xylose and to biotransform some saponins by cleaving outer β-xylose.

11p vihamax2711 21-04-2020 13 0   Download

Production of secondary metabolites from plant tissue culture has emerged as a promising and feasible option attracting the attention of scientists worldwide. Plant cell, tissue and organ cultures offer an attractive alternative for homogeneous, controlled production of secondary metabolites, throughout the year, especially when we take commercial demand into account. They not only facilitate the de novo synthesis of novel compounds, but also are able to produce compounds sometimes even in higher amounts than the intact plants.

9p cothumenhmong1 08-12-2019 17 0   Download

Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products.

17p trinhthamhodang1 16-11-2019 14 1   Download