Bioinformatics analysis

This study determines the interaction between RBPs and target-RNA complexes from public data of the ENCODE project and identifies mutations associated with Mendelian diseases that could disrupt the RBP-RNA interactions.

8p viharuno 03-01-2025 1 1   Download

Phosphoinositide-specific phospholipase C (PI-PLC) has been known as one of the key enzymes that involved in the phospholipid hydrolysis. However, the PI-PLC family in cassava has not been fully recorded. In this study, a comprehensive analysis of the PI-PLC family in cassava assembly has been performed based on various bioinformatics tools.

9p viprimi 16-12-2024 1 1   Download

The research project deals with two different types of data for two separate analysis. The first analysis deals with normalised RNA-seq breast cancer data where machine learning techniques are used to classify and identify the biomarker of cancer. Second analysis deals with raw DNA methylated leukemia samples to determine the mutations.

102p runthenight04 02-02-2023 8 4   Download

To achieve a structural context for the analysis of G-protein coupled recep-tor (GPCR) oligomers, molecular modeling must be used to predict the corresponding interaction interfaces. The task is complicated by the paucity of detailed structural data at atomic resolution, and the large number of possible modes in which the bundles of seven transmembrane (TM) seg-ments of the interacting GPCR monomers can be packed together into dimers and⁄or higher-order oligomers.

13p fptmusic 11-04-2013 50 3   Download

Addition of the second mannose is the only obvious step in glycosylphos-phatidylinositol (GPI) precursor assembly for which a responsible gene has not been discovered. A bioinformatics-based strategy identified the essential Saccharomyces cerevisiaeYbr004c protein as a candidate for the second GPIa-mannosyltransferase (GPI-MT-II). S. cerevisiae cells depleted of Ybr004cp have weakened cell walls and abnormal morphology, are unable to incorporate [ 3 H]inositol into proteins, and accumulate a GPI intermedi-ate having a single mannose that is likely modified with ethanolamine phosphate. ...

9p awards 05-04-2013 30 2   Download

In human monocyte-derived macrophages, the MCPIPgene (monocyte chemoattractant protein-induced protein) is strongly activated by inter-leukin-1b(IL-1b). Using bioinformatics, a PIN domain was identified, span-ning amino acids 130-280; such domains are known to possess structural features of RNases. Recently, RNase properties of MCPIP were confirmed on transcripts coding for interleukins IL-6 and IL-12p40.

14p vinaphone15 28-02-2013 46 3   Download

Activation of hepatic stellate cells (HSCs), which is regulated by multiple signal transduction pathways, is the key event in liver fibrosis. Moreover, members of these pathways are important targets for microRNAs (miR-NAs). To better understand the critical pathways of HSC activation, we performed comprehensive comparative bioinformatics analysis of micro-arrays of quiescent and activated HSCs.

14p vinaphone15 25-02-2013 41 3   Download

Proteomic analysis requires the combination of an extensive suite of tech-nologies including protein processing and separation, micro-flow HPLC, MS and bioinformatics. Although proteomic technologies are still in flux, approaches that bypass gel electrophoresis (gel-free approaches) are domi-nating the field of proteomics.

11p cosis54 09-12-2012 40 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Bioinformatic analysis of the CLE signaling peptide family

15p panasonic06 26-12-2011 45 6   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues...

0p thulanh20 12-11-2011 52 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex...

15p coxanh_8 05-11-2011 48 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis...

11p coxanh_6 30-10-2011 40 3   Download