Bioinformatics method

Ebook "Systems medicine" guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action.

492p dongmelo 27-05-2024 6 2   Download

The exponential growth of bioinformatics in the healthcare domain has revolutionized our understanding of DNA, proteins, and other biomolecular entities. This remarkable progress has generated an overwhelming volume of data, necessitating big data technologies for efficient storage and indexing. While big data technologies like Hadoop offer substantial support for big XML file storage, the challenges of indexing data sizes and XPath query performance persist.

20p dianmotminh02 03-05-2024 2 1   Download

Ebook "Functional coherence of molecular networks in bioinformatics" will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective.

235p ladongphongthanh1008 22-04-2024 5 3   Download

Ebook "Proteomics and protein-protein interactions: Biology, chemistry, bioinformatics, and drug design" attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

325p ladongphongthanh1008 22-04-2024 5 2   Download

Single-cell RNA sequencing (scRNA-Seq) is an increasingly popular platform to study heterogeneity at the single-cell level. Computational methods to process scRNA-Seq data are not very accessible to bench scientists as they require a significant amount of bioinformatic skills.

12p vioraclene 31-03-2024 3 2   Download

Ebook "Protein modelling" detailed description of cutting-edge computational methods applied to protein modeling as well as specific applications are presented. Chapters include: the application of Car-Parrinello techniques to enzyme mechanisms, the outline and application of QM/MM methods, polarizable force fields, recent methods of ligand docking, molecular dynamics related to NMR spectroscopy, computer optimization of absorption, distribution, metabolism and excretion extended by toxicity for drugs, enzyme design and bioinformatics applied to protein structure prediction.

332p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Computational biology: Issues and applications in oncology" provides a comprehensive report on recent techniques and results in computational oncology essential to the knowledge of scientists, engineers, as well as postgraduate students working on the areas of computational biology, bioinformatics, and medical informatics. With chapters timely prepared and written by experts in the field, this in-depth and up-to-date volume covers advanced statistical methods, heuristic algorithms, cluster analysis, data modeling, image and pattern analysis applied to cancer research.

309p cotieubac1004 15-03-2024 4 0   Download

Ebook "G protein-coupled receptors - Modeling and simulation" which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.

228p nhanphanguyet 28-01-2024 5 2   Download

Ebook "Introduction to mathematical methods in bioinformatics" looks at the mathematical foundations of the models currently in use. All existing books on bioinformatics are software-orientated and they concentrate on computer implementations of mathematical models of biology. This book is unique in the sense that it looks at the mathematical foundations of the models, which are crucial for correct interpretation of the outputs of the models.

305p tachieuhoa 28-01-2024 6 2   Download

Ebook "Theory and mathematical methods for bioinformatics" on biomathematics published within the past ten years have consisted of collections of standard bioinformatics problems and informational methods, and focus mainly on the logistics of implementing and making use of various websites, databases, software packages and serving platforms. While these types of books do introduce some mathematical and computational methods alongside the software packages, they are lacking in a systematic and professional treatment of the mathematics behind these methods.

450p tachieuhoa 28-01-2024 5 2   Download

Ebook "Pattern recognition in bioinformatics: 5th IAPR international conference, PRIB 2010 Nijmegen, The Netherlands, September 22-24, 2010 proceedings" has two main objectives: the creation and maintenance of biological databases and the analysis of life sciences data in order to unravel the mysteries of biological function. Computer science methods such as pattern recognition, machine learning, and data mining have a great deal to offer the field of bioinformatics.

458p tachieuhoa 28-01-2024 4 2   Download

Ebook "Genomics of tree crops" cover a wide area of concepts and methods; written by a panel of renowned experts in the field; an indispensable guide for scientists, advanced students, and teachers studying tree genomics. Genomics of Tree Crops is an earnest attempt towards compiling genomics of tree crops.

377p tachieuhoa 28-01-2024 7 2   Download

Ebook "AMPK: Methods and protocols" explores the latest methods used to study AMPK by computational, biochemical, biophysical, cellular, and ex vivo and in vivo approaches. The chapters in this book cover specific topics, such as methods to measure change in cellular energy metabolism and analyze metabolic pathways regulated by AMPK; bioinformatics tools to identify AMPK targets; knockdown of AMPK by CRISPR-Cas9;...

617p lucchinguyen 28-12-2023 4 2   Download

Ebook "Bacterial protein secretion systems: Methods and protocols" details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport.

521p lucchinguyen 28-12-2023 4 2   Download

Ebook "mRNA decay: Methods and protocols" explores the latest methods that can be used to probe mRNA decay pathways and identify mRNA-binding protein targets as well as miRNA targets. Subjects include metabolic labelling and RNAseq methods for determining RNA decay rates, approaches for discovering RNA-binding protein targets, bioinformatics, miRNA targets and novel components of the miRNA-directed decay pathway, and recently developed approaches for studying nonsense-mediated mRNA decay, among other areas.

231p lucchinguyen 28-12-2023 7 2   Download

Part 2 book "Genetics and evolution of infectious diseases" includes content: Evolution of resistance to insecticide in disease vectors, genetics of major insect vectors, multilocus sequence typing of pathogens - methods, analyses, and applications, next generation sequencing, bioinformatics, and infectious diseases, genomics of infectious diseases and private industry, current progress in the pharmacogenetics of infectious disease therapy.... and other contents.

357p oursky07 23-10-2023 2 1   Download

Cuproptosis is a regulated cell death form associated with tumor progression, clinical outcomes, and immune response. However, the role of cuproptosis in pancreatic adenocarcinoma (PAAD) remains unclear. This study aims to investigate the implications of cuproptosis-related genes (CRGs) in PAAD by integrated bioinformatic methods and clinical validation.

18p visharma 20-10-2023 5 3   Download

Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive malignant tumors. Chromobox (CBX) family plays the role of oncogenes in various malignancies. Methods The transcriptional and protein levels of CBX family were confirmed by GEPIA, Oncomine, CCLE, and HPA database. Screening of co-expressed genes and gene function enrichment analysis were performed by GeneMANIA and DAVID 6.8.

17p vioracle 29-09-2023 9 2   Download

Advances in next generation sequencing allow us to do DNA sequencing rapidly at a relatively low cost. Multiple bioinformatics methods have been developed to identify genomic variants from whole genome or whole exome sequencing data. The development of better variant calling methodologies is limited by the difficulty of assessing the accuracy and completeness of a new method.

7p vicaptainmarvel 21-04-2023 5 2   Download

In this paper we present IntroMap, a bioinformatics pipeline for the screening of candidate plants through the application of signal processing techniques to NGS data, using alignment to a reference genome sequence (annotation is not required) that shares homology with the recurrent parental cultivar, and without the need for de novo assembly of the read data or variant calling.

12p vinarcissa 21-03-2023 6 1   Download