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Biological activities ranging
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The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.
18p
dianmotminh02
03-05-2024
2
1
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Ebook "Kinesin protocols (Methods in molecular biology, Volume 164)" present a wide range of domain organizations with a motor domain located at different positions in the molecule. Their motility properties are also variable in directionality, velocity, and such other characteristics as bundling activity and processivity. Finally, and most important, they practicipate in a multitude of cellular functions.
228p
manmanthanhla0201
26-02-2024
3
1
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Ebook "Current topics in developmental biology (Volume 1)" provides both a unique perspective and a much needed resource. Work in zebrafish disease models has expanded beyond genetic disorders and developmental defects, and there is now an active and growing community of researchers studying a range of diseases in zebrafish.
373p
lucchinguyen
28-12-2023
4
2
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Ebook "The handbook of culture and biology" provides an overview of current empirical and theoretical advances in culture and biology interplay research through the work of some of the most influential scholars in the field. Harnessing insights from a range of disciplines and research methods (experiments, genetic epidemiology, naturalistic observations, neuroimaging), it explores diverse topics including animal culture, cultural genomics, and neurobiology of cultural experiences. The authors also advance the field by discussing key challenges and limitations in current research.
543p
lucchinguyen
28-12-2023
7
3
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Insulin-like growth factor binding protein 5 (IGFBP5) is the highest conserved member of IGFBP family, and has the broad range of biological activities effecting on the cell growth. This study aims to investigate the association between genetic variation in IGFBP5 gene and the growth of striped catfish (Pangasianodon hypophthalmus).
11p
vimulcahy
18-09-2023
4
3
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Cobalt ferrite CoFe2O4 (CFO) is a ferromagnetic material with a cubic inverse spinel structure that has the potential to be widely applied in various interdisciplinary fields ranging from information storage, electronic devices, electromagnetic interference suppressors, electromagnetic wave absorbers, sensors, catalytic to the environment, medical.
7p
viengels
25-08-2023
9
2
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Imidazole derivatives are one of the most important classes of nitrogen-containing five-membered heterocycles with a wide range of biological activities. Thus, the synthesis of these heterocycles has attracted intensive research interest.
8p
vidudley
20-02-2023
5
2
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Onosma L., the largest genus of Boraginaceae, is represented by 105 species in Turkey with an endemism rate of 52%. Phytochemical studies indicate that Boraginaceae plants mainly comprise naphthoquinones with a wide range of biological activities including anticancer, antiinflammatory, wound healing, and antioxidant effects. However, few taxa of the genus Onosma have been investigated in detail for their bioactivities.
13p
lyhuyenthu
31-01-2023
5
2
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Chalcones are a class of compounds with a wide range of biological activities. In addition, derivatives based on the quinazolinone skeleton are currently of interest to research in the screening of compounds with cytotoxic effects. Compounds containing chalcone structures on the basis of quinazolinone can yield new structures with cytotoxic effects.
8p
viporsche
25-10-2022
6
2
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Recently, it has become clear that some promoters function as long-range regulators of gene expression. However, direct and quantitative assessment of enhancer activity at long intergenic noncoding RNA (lincRNA) or mRNA gene bodies has not been performed.
14p
vigalileogalilei
27-02-2022
11
1
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The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is controlled by regulatory elements located in the centromeric TAD (C-DOM) through long-range contacts.
15p
vialfrednobel
29-01-2022
13
0
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Herpesviruses can infect a wide range of animal species. Herpes simplex virus 1 (HSV-1) is one of the eight herpesviruses that can infect humans and is prevalent worldwide. Herpesviruses have evolved multiple ways to adapt the infected cells to their needs, but knowledge about these transcriptional and post-transcriptional modifications is sparse.
19p
vialfrednobel
29-01-2022
10
0
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The impact of signal-dependent transcription factors, such as glucocorticoid receptor and nuclear factor kappa-b, on the three-dimensional organization of chromatin remains a topic of discussion. The possible scenarios range from remodeling of higher order chromatin architecture by activated transcription factors to recruitment of activated transcription factors to pre-established long-range interactions.
15p
viaristotle
29-01-2022
12
0
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The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation.
15p
viaristotle
29-01-2022
16
0
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The physiological role of lectins in a plant is still not well understood. The overabundant presence of lectins in plant seeds and storage tissues indicated their role in plant development. Plant lectins shows a broad range of activities like antibacterial, antifungal, insecticidal, anticancerous, antileishmanial, antiviral, and anticoagulants. In this review, we aim to highlight the plant lectins classification and their application in various biological aspects.
10p
mudbound
10-12-2021
12
1
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Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20–34) and 4,6-diarylpyrimidine-2(1H)-thiol derivatives (35–44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1- one compounds (1–19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20–44) were evaluated with regard to their α-glucosidase activity. However, only compounds 22–25, 27, 31, 34, 35, 37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC50 values of the active compounds ranged between 2.36 and 13.
16p
tudichquannguyet
29-11-2021
9
1
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The tetrahydropyridine (THP) ring system has received considerable focus due to its excellent ability to act as a pharmacophore. It is recognized as a major constituent in natural alkaloids. THP derivatives have been reported for a diverse range of biological activities. Recent synthetic works contain syntheses of monosubstituted, disubstituted, trisubstituted, highly functionalized, and condensed structures. In this review, we summarize the recent literature dealing with the bioactive nature of this important heterocycle.
26p
tudichquannguyet
29-11-2021
6
0
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The absolute configuration of compound 14 was found as SR in the solid state. Analytical and spectroscopic data of the phosphazenes were consistent with their suggested structures. Antimicrobial activities of the benzyl-pendant-armed cyclotriphosphazenes were scrutinized against G(+) and G(−) bacteria and yeast strains. The bacterium most affected by the synthesized compounds was Pseudomonas aeruginosa. Minimum inhibitory concentrations and minimal bacterial concentrations were in the range of 125–500 µM.
26p
tudichquannguyet
29-11-2021
9
1
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The nanostructuring of hydroxyl-substituted diazacrown-ether (DC) by silver nanoparticles was obtained by green synthesis method in order to increase the antibacterial activity of silver nanoparticles. The synthesized DC, nanoparticles, and nanosupramolecular complex (Ag@DC) were studied by TEM, powder-XRD, and NMR, IR, and UV spectroscopy methods. The Ag@DC nanostructures were uniform and their sizes ranged from 8 to 18 nm. IR and UV spectra revealed the noncovalent formation of the nanosupramolecular complex.
11p
tudichquannguyet
29-11-2021
7
0
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E2F6 is a member of the E2F family of transcription factors involved in regulation of a wide variety of genes through both activation and repression. E2F6 has been reported as overexpressed in breast cancers but whether or not this is important for tumor development is unclear. We first checked E2F6 expression in tumor cDNAs and the protein level in a range of breast cancer cell lines.
13p
thiencuuchu
27-11-2021
6
0
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