Biological discoveries

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses.

113p vimeyers 29-05-2024 3 2   Download

This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development.

339p vimeyers 29-05-2024 4 2   Download

Building on the success of the previous editions, the Textbook of drug design and discovery, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

451p vimeyers 29-05-2024 3 2   Download

Cancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells.

10p dianmotminh02 03-05-2024 4 1   Download

Ebook "Dictyostelids: Evolution, genomics and cell biology" covers the latest advances in our knowledge of these extraordinary organisms with topics spanning from their evolutionary history, ecology and diversity to the recent discoveries regarding their cellular and molecular biology.

259p ladongphongthanh1008 22-04-2024 7 2   Download

Ebook "Development of the inner ear" provides a detailed overview of the development of the inner ear, particularly as our understanding has increased in the last decade of the twentieth century and the first five years of the twenty-first. They complete their chapter with suggestions for areas of future research and discovery.

250p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Molecular biology of long non-coding RNAs" will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

232p tracanhphuonghoa1007 22-04-2024 1 1   Download

Ebook "Prominin-1 (CD133): New insights on stem & cancer stem cell biology" was conceived to celebrate the fi fteenth anniversary of the discovery of prominin-1, also known in the medical fi eld as CD133. This book is composed of 15 chapters that will describe, on one hand, the molecular and cellular biology of prominin-1 and other members of the prominin family and, on the other hand, the importance of this molecule in the medical fi eld as a valuable marker of stem and cancer stem cells.

255p tracanhphuonghoa1007 22-04-2024 7 1   Download

Ebook "Adult stem cells: Biology and methods of analysis" offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells, while it also describes and critically evaluates the methods currently used to assess stem cell self-renewal.

282p tracanhphuonghoa1007 22-04-2024 5 2   Download

Ebook "Ten years of progress in GW/P body research" richly explores these original scienti fi c discoveries and many of the subsequent detailed studies of the components and functions of RNA processing that take place in GW/P bodies. The author list is truly impressive and reading the history will pique the interests of students and senior investigators, and hopefully, provide insights into future directions of the fi eld of RNA biology.

280p tracanhphuonghoa1007 22-04-2024 1 1   Download

Ebook "X-ray free electron lasers: A revolution in structural biology" aims to provide the readers with an overview of the new methods that have been recently developed as well as a prospective on new methods under development. It highlights the most important and novel Structural Discoveries made recently with XFELS, contextualized with a big-picture discussion of future developments.

486p tracanhphuonghoa1007 22-04-2024 5 3   Download

Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism.

14p vibransone 28-03-2024 5 2   Download

Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

248p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "Amination and formation of sp2 C–N bonds (Topics in Organometallic chemistry, Volume 46)" highlights in the first chapter, written by Lemen and Wolfe, the discovery and the development of original palladium-based catalysts for C(sp2 )-N bond formation via the coupling of nitrogen nucleophiles and aryl/alkenyl halides and pseudohalides. The authors also report various applications of these transformations to the synthesis of useful compounds, including biologically active molecules and materials.

214p coduathanh1122 27-03-2024 7 1   Download

Ebook "Novel synthetic chemistry of ureas and amides" investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive.

179p coduathanh1122 27-03-2024 3 1   Download

Ebook "Vanadium: Biochemical and molecular biological approaches" is particularly timely as it exactly coincides with the centennial anniversary of the discovery of vanadium by Professor Henze, in the blood cells of an ascidian (tunicate) collected in Gulf of Naples in 1911. Vanadium, atomic number 23, covers a wide range of oxidation states (from -2 to +5) and has unpaired electrons. Depending on these properties, a wide variety of enzymes and compounds containing vanadium have been found and the biochemical behaviour of vanadium has been investigated extensively.

235p coduathanh1122 27-03-2024 4 1   Download

Ebook "HOX gene expression (Molecular biology intelligence unit)" is crucial not only in exploring the enigma of homeosis but also in understanding normal development at the fundamental molecular level. "Hox Gene Expression" starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes- their evolution, structure, normal and abnormal function.

158p cotieubac1004 15-03-2024 1 0   Download

Ebook "Modern molecular biology: Approaches for Unbiased discovery in cancer research" is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics.

196p cotieubac1004 15-03-2024 1 0   Download

Ebook "The biology of gastric cancers" represents the very first volume devoted to the subject of the basic biology of gastric cancer. Although there were major achievements 30–40 years ago in the description of the histopathology of stomach tumors and the preneoplastic conditions that preceded these lesions, it was of course the pioneering (and Nobel prize– winning) studies involving the discovery of Helicobacter pylori by Marshall and Warren that set the stage for the more recent insights on the role of chronic inflammation and cancer.

654p cotieubac1004 15-03-2024 0 0   Download

Ebook "RAMPs (Advances in experimental medicine and biology, Volume 744)" provides a general introduction to RAMPs including its discovery. The second chapter (by Poyner and colleagues) and the third chapter (by Bomberger and colleagues) are intended to provide in depth discussion on how the different RAMP isoforms can regulate various aspects of receptor signaling especially stimulated with calcitonin gene related peptide (CGRP) and adrenomedullin. In addition, in the third chapter, Bomberger et al discuss the differences in RAMP2 and -3 with regard to their role in receptor trafficking.

126p cotieubac1004 15-03-2024 2 0   Download