Biological phenotypes

Ebook "Longevity genes: A blueprint for aging" describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

199p ladongphongthanh1008 22-04-2024 3 2   Download

Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism.

14p vibransone 28-03-2024 5 2   Download

The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors.

19p vioraclene 31-03-2024 3 2   Download

Abnormal DNA methylation is observed as an early event in breast carcinogenesis. However, how such alterations arise is still poorly understood. microRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play key roles in various biological processes.

21p vibransone 28-03-2024 4 2   Download

In ebook "Weighted network analysis: Applications in genomics and systems biology" high-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.

433p cotieubac1004 15-03-2024 6 0   Download

Ebook "Crop systems biology: Narrowing the gaps between crop modelling and genetics" will be meant for those scientists and graduate students from fundamental plant biology and applied crop science who are interested in bridging the gap between these two fields. We have invited a group of scientists (who have very good track records in publishing excellent papers in this field or in a closely related area) to contribute chapters to this new book, and they have agreed to do so.​

241p cotieubac1004 15-03-2024 5 0   Download

Transcriptional classifcation has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent discrete, mutually exclusive entities or molecular/phenotypic states with potential overlap.

17p vicwell 29-02-2024 4 1   Download

Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive. With emerging multimodal data for these mechanisms, machine learning methods can be applied for phenotype prediction at different scales, but due to the black-box nature of machine learning, integrating these modalities and interpreting biological mechanisms can be challenging.

19p vicwell 29-02-2024 4 2   Download

In ebook "Ecology and the environment (The plant sciences series)" plant biology is considered from the perspective of plants and their surrounding environment, including both biotic and abiotic interactions. The intended audience is undergraduate students in the middle or final phases of their programs of study.

675p manmanthanhla0201 26-02-2024 4 1   Download

Ebook "Evolutionary biology: Biodiversification from genotype to phenotype" presents 20 selected contributions to the 18th Evolutionary Biology Meeting, which took place in September 2014 in Marseille. The aims of these annual meetings in Marseille are to bring together leading evolutionary biologists and other scientists who employ evolutionary biology concepts, e.g. for medical research, and to promote the exchange of ideas and encourage interdisciplinary collaborations.

406p manmanthanhla0201 26-02-2024 2 1   Download

Ebook "Applied bioinformatics: An introduction" introduces readers to the basic principles of bioinformatics and the practical application and utilization of computational tools, without assuming any prior background in programming or informatics. It provides a coherent overview of the complex field and focuses on the implementation of online tools, genome databases and software that can benefit scientists and students in the life sciences.

297p tachieuhoa 28-01-2024 7 2   Download

Ebook "Managing the prenatal environment to enhance livestock productivity" reviews phenotypic consequences of prenatal development, and provides details of mechanisms that underpin these effects in ruminants, pigs and poultry. The chapters have been divided into three parts: Quantification of prenatal effects on postnatal productivity, mechanistic bases of postnatal consequences of prenatal development and regulators of fetal and neonatal nutrient supply.

303p tachieuhoa 28-01-2024 3 2   Download

Ebook "Antibiotic resistance protocols (Third edition)" provides a wide range of different technologies, ranging from conventional growth basic techniques, application of molecular biology, development of resistance mutations, and diagnosis and monitoring treatment response. New and updated chapters cover techniques from the microscopic scale to whole animal models.

169p lamquandat 28-12-2023 4 2   Download

Ebook "Mammary gland development: Methods and protocols" provides key molecular biological protocols and experimental strategies currently employed to study the various stages of mammary gland development. Chapters are divided into four parts covering genetically modified mouse models that exhibit prenatal and pubertal mammary gland phenotypes, 2D and 3D-model culture systems, methodologies for mammary stem cell isolation, and translational applications that provide a bridge between experimental studies of mammary gland development and the study of human breast cancer.

357p lucchinguyen 28-12-2023 7 3   Download

Part 1 book "Reproductive endocrinology" includes content: Introduction to the molecular organization of the endocrine reproductive system; extracellular signaling receptors; the molecules that transmit information into the cell - the intracellular signaling pathways; introduction to molecular biology - structure and function of the macromoleculesof genetic information; regulation of gene expression; molecular basis of abnormal phenotype; recombinant DNA technology,... and other contents.

159p muasambanhan03 25-12-2023 1 1   Download

Nuclear receptor subfamily 1 group H member 4 (NR1H4) have been reported in various cancer types, however, little is known about the clinical values and biological function in clear cell Renal cell carcinoma (ccRCC).

17p vialfrednobel 23-12-2023 3 3   Download

Distant metastasis remains the main cause of death in breast cancer. Breast cancer risk is strongly influenced by pathogenic mutation. This study was designed to develop a multiple-feature model using clinicopathological and imaging characteristics adding pathogenic mutations associated signs to predict recurrence or metastasis in breast cancers in high familial risk women.

13p vischultz 20-10-2023 4 1   Download

Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects of different biological data types can boost learning capabilities and lead to a better understanding of the underlying interactions among molecular levels.

10p visteverogers 24-06-2023 8 2   Download

The discovery of selection signatures has enabled the identification of genomics regions under selective pressure, enhancing knowledge of evolutionary genotype-phenotypes. Sex chromosomes play an important role in species formation and evolution. Therefore, the exploration of selection signatures on sex chromosomes has important biological significance.

10p vihagrid 30-01-2023 6 3   Download

Gastric Cancer (GC) is the fourth most deadly cancer worldwide. Enhanced understanding of its key epidemiological and molecular drivers is urgently needed to lower the incidence and improve outcomes. Further‑ more, tumor biology in European (EU) and Latin American (LATAM) countries is understudied.

8p visusanwojcicki 28-06-2022 14 2   Download