Biological signaling

Glioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features including extensive hypoxia. Hypoxia in glioblatoma associates with complex signaling patterns including activation of several pathways such as MAPK, PI3K-AKT/mTOR and IL-6/JAK/STAT3 with the master regulator HIF-1, which in turn drive particular tumor behaviors determining, in the end, treatment outcomes and patients fate.

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Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of glioma. In order to investigate the biological role of RTEL1 in glioma.

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This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases.

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Ebook "Systems medicine" guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action.

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Ebook "Notch signaling in embryology and cancer" is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer.

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Ebook "Biology of the fungal cell: Volume VIII (2nd edition)" provides readers with contents including: the endomembrane system of the fungal cell; motile tubular vacuole systems; the fungal woronin body; a molecular and genomic view of the fungal cell wall; the cytoskeleton and polarized growth of filamentous fungi; polarised growth in fungi; signal transduction and morphogenesis in candida albicans;...

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Ebook "Biology in stem cell niche" explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives.

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Ebook "Biophotonics and coherent systems in biology" provides readers with contents including: from mitogenetic rays to biophotons; photon sucking as an essential principle of biological regulation; quantum squeezed state description of spectral decompositions of a biophoton signal and the possibility of remote intervention; biological structure as a converter of coherent radiation;...

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Ebook "The neuropilins: Role and function in health and disease" covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases.

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Ebook "Proteomics and protein-protein interactions: Biology, chemistry, bioinformatics, and drug design" attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

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Ebook "Phase transitions in cell biology" should be suitable for anyone interested in the nature of biological function, particularly those who tire of lumbering along well trodden pathways of pursuit, and are eager to hear something fresh. The book is replete with fresh interpretations of familiar phenomena, and should serve as an excellent gateway to deeper understanding.

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Ebook "Molecular and cellular biology of platelet formation: Implications in health and disease" gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research.

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Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.

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Ebook "NF-KB/Rel transcription factor family" has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.

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Ebook "Handbook of Maize: Its biology" centers on the past, present and future of maize as a model for plant science research and crop improvement. The book includes brief, focused chapters from the foremost maize experts and features a succinct collection of informative images representing the maize germplasm collection.

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Ebook "Systems biology of apoptosis" summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches.

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Ebook "Frontiers in computational and systems biology" consists of 19 chapters and covers a wide spectrum of topics. Described applications of an RNA structure sampling algorithm to the rational design of short interfering RNAs for gene silencing by RNA interference and to target identification for microRNAs that play important roles in posttranscriptional gene regulation.

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Ebook "Mast cell biology: Contemporary and emerging topics" have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.

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In ebook "Developmental biology of neoplastic growth" tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest.

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Ebook "Biology of inositols and phosphoinositides: Subcellular biochemistry (Volume 39)" describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward.

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