Biopharmaceuticals

Efavirenz (EFZ) is one of the most used drugs in the treatment of AIDS and is the first antiretroviral choice. However, since it has low solubility, it does not exhibit suitable bioavailability, which interferes with its therapeutic action and is classified as a class II drug according Biopharmaceutical Classification System (low solubility and high permeability).

8p vihermione 06-01-2023 8 1   Download

Nanosponges are a novel class of hyperbranched cyclodextrin-based nanostructures that exhibits remarkable potential as a drug host system for the improvement in biopharmaceutical properties. This work aims the development of cyclodextrin-based nanosponge of norfloxacin to improve its physicochemical characteristics.

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Mechanical characterisation of agarose-based resins is an important factor in ensuring robust chromatographic performance in the manufacture of biopharmaceuticals. Pressure-flow profiles are most commonly used to characterise these properties.

9p viginny 23-12-2022 3 2   Download

In the biopharmaceutical industry, pre-packed columns are the standard for process development, but they must be qualified before use in experimental studies to confirm the required performance of the packed bed. Column qualification is commonly done by pulse response experiments and depends highly on the experimental testing conditions.

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Monoclonal antibodies (mAbs) dominate themarketfor biopharmaceutical proteins because they provide active and passive immunotherapies for many different diseases. However, for most mAbs,two expensive manufacturing platforms are required.

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Current biopharmaceutical production heavily relies on chromatography for protein purification. Recently, research has intensified towards finding suitable solutions to monitoring the chromatographic steps by multivariate spectroscopic sensors.

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Pre-packed chromatography columns are routinely used in downstream process development and scaledown studies. In recent years they have also been widely adopted for large scale, cGMP manufacturing of biopharmaceuticals.

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To obtain consistent chromatographic behavior, it is important to develop resin packing methods in accordance with the characteristics of each resin. Resins, particularly those with a significant level of compressibility, require proper knowledge of the packing methodology to ensure scalable performance.

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Plants are advantageous as biopharmaceutical manufacturing platforms because they allow the economical and scalable upstream production of proteins, including those requiring post-translational modifications, but do not support the replication of human viruses. However, downstream processing can be more labor-intensive compared to fermenter-based systems because the product is often mixed with abundant host cell proteins.

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In the last decade, there has been a growing interest in developing microfluidic systems as new scaledown models for accelerated and cost-effective biopharmaceutical process development. Nonetheless, the research in this field is still in its infancy and requires further investigation to simplify and accelerate the microfabrication process.

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Endotoxins are a highly pyrogenic and immunogenic contaminant of bacterial origin that must be avoided during the manufacturing of biopharmaceutical products to ensure safety and efficacy. Low endotoxin recovery, also known as a masking effect, is defined as the ability to detect

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Various high-throughput systems and strategies are employed by the biopharmaceutical industry for early to late-stage process development for biologics manufacturing. The associated increases to experiment productivity and reduction in material consumption makes high throughput tools integral for bioprocess development.

11p vironald 15-12-2022 3 1   Download

Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal antibodies (mAb) are one of the most widely used therapeutic proteins and are important for the treatment of cancer and autoimmune diseases, among others.

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The trend in the biopharmaceutical industry is changing from batch process to continuous process. For continuous biomanufacturing, traceability of the material is required by regulatory authorities.

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Protein aggregation is a significant problem in the biopharmaceutical industry (protein drug stability) and is associated medically with over 40 human diseases. Although a number of computational models have been developed for predicting aggregation propensity and identifying aggregation-prone regions in proteins, little systematic research has been done to determine physicochemical properties relevant to aggregation and their relative importance to this important process.

9p viwyoming2711 16-12-2020 3 0   Download

Over the last 20 years in biotechnology, the production of recombinant proteins has been a crucial bioprocess in both biopharmaceutical and research arena in terms of human health, scientific impact and economic volume. Although logical strategies of genetic engineering have been established, protein overexpression is still an art.

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The present study was carried out on Sprague Dawley rats to evaluate the sub-acute toxicity of an anti - tumor necrosis factor -alpha receptor fusion protein named etanercept. Etanercept is a biopharmaceutical compound and is the first anti-tumor necrosis factor agent to be approved for the treatment of rheumatoid arthritis.

17p nguaconbaynhay7 15-08-2020 7 0   Download

This present study was aimed to identify the skin sensitization potential of the etanercept, in guinea pigs by following Guinea Pig Maximization Test (GPMT) of Magnusson and Kligman method. The animals were divided into two groups; negative control comprising six males and 6 females and treatment groups having ten males and ten females.

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Công văn số 6991/CT-TTHT năm 2019 về thuế thu nhập cá nhân do Cục thuế thành phố Hồ Chí Minh ban hành. Mời các bạn cùng tham khảo chi tiết nội dung công văn.

2p jiangfengmian 17-06-2020 10 1   Download

Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics. One of the methods usually used for characterization and quantification of biopharmaceuticals is amino acid analysis

18p vijiraiya2711 27-05-2020 6 1   Download