Brain evolution
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Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.
10p vioraclene 31-03-2024 3 1 Download
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Ebook "Culture and neural frames of cognition and communication" is organized so that two chapters provide general views of the relation between biological evolution, cultural evolution and recent cultural neuroscience studies, while other chapters focus on several aspects of human cognition that have been shown to be strongly influenced by sociocultural factors such as self-concept representation, language processes, emotion, time perception, and decision-making.
316p tachieuhoa 28-01-2024 10 2 Download
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Across recent decades, profound changes in the practice of medicine have been accompanied by parallel developments in the daily mental efforts of medical professionals. Using visual metaphors and hand-drawn illustrations, the author explores the evolution of one physician’s brain over the past 25 years.
5p visteverogers 24-06-2023 3 2 Download
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The methyl-CpG Binding Protein two gene (MECP2) encodes a multifunctional protein comprising two isoforms involved in nuclear organization and regulation of splicing and mRNA template activity. This gene is normally expressed in all tissues, with a higher expression level in the brain during neuronal maturation.
11p vinarcissa 21-03-2023 4 1 Download
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The availability of high-coverage genomes of our extinct relatives, the Neanderthals and Denisovans, and the emergence of large, tissue-specific databases of modern human genetic variation, offer the possibility of probing the effects of modern-derived alleles in specific tissues, such as the brain, and its specific regions.
10p vihagrid 30-01-2023 6 3 Download
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To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals.
43p viarchimedes 26-01-2022 4 0 Download
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The complex interspersed pattern of segmental duplications in humans is responsible for rearrangements associated with neurodevelopmental disease, including the emergence of novel genes important in human brain evolution.
35p viarchimedes 26-01-2022 6 0 Download
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Gene expression variation is a key underlying factor influencing phenotypic variation, and can occur via cis- or trans-regulation. To understand the role of cis- and trans-regulatory variation on population divergence in chicken, we developed reciprocal crosses of two chicken breeds, White Leghorn and Cornish Game, which exhibit major differences in body size and reproductive traits, and used them to determine the degree of cis versus trans variation in the brain, liver, and muscle tissue of male and female 1-day-old specimens.
10p viansan2711 30-07-2021 18 1 Download
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Large difference in cerebrum size exist between avian species and populations of the same species and is believed to reflect differences in processing power, i.e. in the speed and efficiency of processing information in this brain region.
11p vijeeni2711 30-06-2021 15 1 Download
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Understanding cellular and molecular heterogeneity in glioblastoma (GBM), the most common and aggressive primary brain malignancy, is a crucial step towards the development of effective therapies. Besides the inter-patient variability, the presence of multiple cell populations within tumors calls for the need to develop modeling strategies able to extract the molecular signatures driving tumor evolution and treatment failure.
12p vicolorado2711 22-10-2020 15 1 Download
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Evolution of multi drug resistant isolates has become rampant in today’s world. The credit of this goes to the incomplete dosage and irrational use of antibiotics. The human brains are now in search of alternate methods. Use of Silver nanoparticles is one amongst them. In the following study, 50 multi-drug resistant clinical isolates of P. aeruginosa acquired from the intensive care units were tested with antibiotics, AgNps and AgNp-antibiotic conjugates. The conjugates were prepared by impregnating 30 µl of AgNps in sterile plain disks and the antibiotic disks separately.
6p angicungduoc5 14-06-2020 28 1 Download
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Brain metastases often occur in cancer evolution. They are not only responsible for death but also for disorders affecting the quality of life and the cognitive functions.
9p vijakarta2711 09-06-2020 11 1 Download
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Tham khảo sách 'evolution of the molecular biology of brain tumors and the therapeutic implications edited by terry lichtor', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
648p xumxaxumxit 09-04-2013 62 8 Download
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Although technical advances have resulted in marked improvements in the ability to diag‐ nose and surgically treat primary and metastatic brain tumors, the incidence and mortality rates of these tumors is increasing. Particularly affected are young adults and the elderly. The present standard treatment modalities following surgical resection including cranial irradia‐ tion and systemic or local chemotherapy each have limited efficacy and serious adverse side effects.
648p lyly_5 22-03-2013 41 7 Download
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Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins. Of particular inter-est is transthyretin, which in mammals is synthesized in the liver, choroid plexus, meninges
15p viettel02 20-02-2013 37 2 Download
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It was 2538 years After the Year of the Son of Man. For six centuries mankind had been developing machines. The Ear-apparatus was discovered as early as seven hundred years before. The Eye came later, the Brain came much later. But by 2500, the machines had been developed to think, and act and work with perfect independence. Man lived on the products of the machine, and the machines lived to themselves very happily, and contentedly. Machines are designed to help and cooperate. It was easy to do the simple duties they needed to do that men might live well. And men had created them.
24p hotmoingay8 28-01-2013 52 1 Download
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MNB⁄DYRK1A is a member of the dual-specificity tyrosine phosphoryla-tion-regulated kinase (DYRK) family that has been strongly conserved across evolution. There are substantial data implicating MNB⁄DYRK1A in brain development and adult brain function, as well as in neurodegener-ation and Down syndrome pathologies.
13p mobifone23 07-01-2013 38 3 Download
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It would seem that an introduction to oxygen is unnecessary, for we deal with it and depend upon it every moment of our lives. Oxygen is to us the essential stuff of the air we breathe. We are aerobic animals who obtain energy by oxidizing foodstuffs. As such, we are wholly dependent on oxygen for life – go without it for a couple of minutes and we panic and may even suffer irreversible brain damage. In a few more minutes, we perish. Animal metabolism depends upon oxygen for almost all of its energy-generating processes. Yet this was not always so. Early in the history of the Earth,...
0p thienbinh1311 13-12-2012 41 3 Download
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Isn’t it strange that the animal we used to be developed into the creature that we now are? How – and why – did human intelligence and culture evolve? How did we evolve minds, philosophies and technologies? And now that we have them, where are they taking us? The orthodox answer to these questions looks inside our brains to see what they are made of and how the various components operate.
337p camchuong_1 04-12-2012 61 4 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evolution of changes in the computed tomography scans of the brain of a patient with left middle cerebral artery infarction: a case report
4p dauphong1 22-12-2011 36 3 Download