Brain tumors

In this thesis, the author focussed on providing an application framework to be used in brain segmentation - the process of tumor detection. This constitutes setting up software bundled into a Window machine which is easily distributable. Moreover, a segmentation algorithm was implemented and tested using the provided software. In order to test the bundled software by implementing specific brain segmentation from the literature, the author used CT scans freely available from the database of 108 Central Military Hospital.

85p capheviahe27 23-02-2021 19 3   Download

Wilson disease (WD), an inherited disorder affecting copper metabolism, is characterized by hepatic cirrhosis and neuronal degeneration, which result from toxic levels of copper that accumulate in the liver and brain, respectively. We reported previously that the  1.3-kb promoter of the WD gene contains four metal response elements (MREs). Among the four MREs, MREa plays the most important role in the transcriptional activation of the WD promoter.

11p research12 01-06-2013 54 3   Download

d-Atracotoxins (d-ACTXs) from Australian funnel-web spiders differ structurally from scorpion a-toxins (ScaTx) but similarly slow sodium current inactivation and compete for their binding to sodium channels at receptor site-3. Characterization of the binding of 125 I-labelled d-ACTX-Hv1a to various sodium channels reveals a decrease in anity for depolarized (0 mV;Kdˆ6.5 ‹1.4 nM) vs.polar-ized ()55 mV;Kdˆ0.6‹0.2nM) rat brain synaptosomes.

11p research12 29-04-2013 36 5   Download

Hsp105aisoneof themajormammalianheat shockproteins that belongs to the HSP105/110 family, and is expressed at especially high levels in the brain as compared with other tissues in mammals. Previously, we showed that Hsp105a prevents stress-induced apoptosis in neuronal PC12 cells, and is a novel anti-apoptotic neuroprotective factor in the mammalian brain.

9p research12 23-04-2013 43 1   Download

We have recently identified an Ets element controlling over 90%of the basal expression of the human presenilin 1 (PS1) gene. We have also shown that Ets1 and Ets2 act as trans-activators of the PS1 gene by cotransfection experiments in SK-N-SH neuronal cells. The PS1 gene is widely but dif-ferentially expressed across tissues and the expression in brain appears to be restricted to neurons. To gain further insight into the regulation of the gene we have examined the regulation of PS1 by 12-O-tetradecanoylphorbol 13-acetate (TPA). ...

7p tumor12 22-04-2013 29 4   Download

Theb-amyloid peptide (Ab) is a major component of toxic amyloid plaques found in the brains of patients with Alzheimer’s disease.Abis liberated by sequential cleavage of amyloid precursor protein (APP) byb-andc-secre-tases.The level of Abdepends directly on the hydrolytic activity ofb-secretase.Therefore, b-secretase is an excel-lent target for drug design.An approach based on RNA-cleaving ribozymes was developed to control expression ofb-secretase.

9p tumor12 20-04-2013 38 4   Download

TheST2gene, which is specifically induced by growth sti-mulation in fibroblasts, encodes interleukin-1 receptor-rela-tedproteins and iswidely expressed in hematopoietic, helper T, and various cancer cells. However, the physiological as well as pathological functions of the ST2 gene products are not yet fully understood. In this study, we analyzed the expression of theST2gene in human glioma cell lines and human brain tumor samples with real-time polymerase chain reactionmethod,

8p tumor12 20-04-2013 48 4   Download

Incubation of an NAD + -dependent succinic semialdehyde dehydrogenase from bovine brain with 4-dimethylamino-azobenzene-4-iodoacetamide (DABIA) resulted in a time-dependent loss of enzymatic activity. This inactivation followed pseudofirst-order kinetics with a second-order rate constant of 168M )1 Æmin )1 .The spectrumofDABIA-labeled enzyme showed a characteristic peak of the DABIA alkyl-ated sulfhydryl group chromophore at 436 nm, which was absent from the spectrum of the native enzyme.

0p awards 05-04-2013 31 2   Download

The interplay among reactive oxygen species (ROS) formation, elevated intracellular calcium concentration and mitochondrial demise is a recurring theme in research focusing on brain pathology, both for acute and chronic neurodegenerative states. However, causality, extent of contribution or the sequence of these events prior to cell death is not yet firmly established.

18p dell39 27-03-2013 43 3   Download

RasGRF is a family of guanine nucleotide exchange factors with dual spe-cificity for both Ras and Rac GTPases. In this study, using mouse brain extracts, we show that both RasGRF1 and RasGRF2 interact with micro-tubules in an in vitro microtubule assembly system and this binding is very tight. To characterize this association, recombinant purified proteins con-taining different regions of RasGRF1 were tested for their ability to bind microtubules preassembled from pure tubulin.

12p inspiron33 26-03-2013 49 4   Download

N-Glycosylation is a cotranslational and post-translational process of pro-teins that may influence protein folding, maturation, stability, trafficking, and consequently cell surface expression of functional channels. Here we have characterized two consensus N-glycosylation sequences of a voltage-gated K + channel (Kv3.1). Glycosylation of Kv3.1 protein from rat brain and infected Sf9 cells was demonstrated by an electrophoretic mobility shift assay.

14p inspiron33 25-03-2013 56 4   Download

Hemitoxin (HTX) is a new K + channel blocker isolated from the venom of the Iranian scorpionHemiscorpius lepturus. It represents only 0.1% of the venom proteins, and displaces [ 125 I]a-dendrotoxin from its site on rat brain synaptosomes with an IC50value of 16 nm.

10p galaxyss3 07-03-2013 35 3   Download

It has been recently established that in various brain regions d-serine, the product of serine racemase, occupies the so-called ‘glycine site’ within N-methyl d-aspartate receptors. Mammalian brain serine racemase is a pyridoxal-5¢ phosphate-containing enzyme that catalyzes the racemization ofl-serine to d-serine.

8p galaxyss3 07-03-2013 33 4   Download

Formation of new blood vessels is required for the growth and metastasis of all solid tumors. New blood vessels are established in tumors mainly through angiogenesis. Brain tumors in particular are highly angiogenic. Therefore, interventions designed to prevent angiogenesis may be effective at controlling brain tumors.

12p vinaphone15 25-02-2013 49 3   Download

Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins. Of particular inter-est is transthyretin, which in mammals is synthesized in the liver, choroid plexus, meninges

15p viettel02 20-02-2013 40 3   Download

Atrial natriuretic factor receptor guanylate cyclase (ANF-RGC) is the receptor and the signal transducer of two natriuretic peptide hormones: atrial natriuretic factor and brain natriuretic peptide. It is a single trans-membrane-spanning protein. It binds these hormones at its extracellular domain and activates its intracellular catalytic domain.

14p mobifone23 21-01-2013 38 5   Download

Alzheimer’s disease (AD) is an age-related, progressive degenerative dis-order that is characterized by synapse and neuron loss in the brain and the accumulation of protein-containing deposits (referred to as ‘senile plaques’) and neurofibrillary tangles. Insoluble amyloid b-peptide (Ab) fibrillar aggregates found in extracellular plaques have long been thought to cause the neurodegenerative cascades of AD.

11p mobifone23 18-01-2013 45 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Abstract Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still poor.

10p dauphong4 03-01-2012 64 5   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Immunological considerations of modern animal models of malignant primary brain tumors

9p dauphong3 03-01-2012 42 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors

14p dauphong3 03-01-2012 62 3   Download