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Cancer entities
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Pancreatic ductal adenocarcinoma (PDAC) is a ‘difcult-to-treat’ entity. To forecast its prognosis, we introduced a new biomarker, SARIFA (stroma areactive invasion front areas), which are areas at the tumour invasion front lacking desmoplastic stroma reaction upon malignant invasion in the surrounding tissue, leading to direct contact between tumour cells and adipocytes.
12p
vikoch
27-06-2024
1
1
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The “HER2-low” nomenclature identifies breast carcinomas (BCs) displaying a HER2 score of 1+/2+ in immunohistochemistry and lacking ERBB2 amplification. Whether HER2-low BCs (HLBCs) constitute a distinct entity is debated.
16p
viellison
28-03-2024
3
1
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Transcriptional classifcation has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent discrete, mutually exclusive entities or molecular/phenotypic states with potential overlap.
17p
vicwell
29-02-2024
4
1
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Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other cancer entities have revealed differences in treatment response and prognosis. However, only limited data in OPSCC according to gender and human papillomavirus (HPV) status exist.
12p
vialfrednobel
23-12-2023
5
3
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Composition of the intestinal microbiota has been correlated to therapeutic efficacy of immune check‑point inhibitors (ICI) in various cancer entities including melanoma. Prediction of the outcome of such therapy, how‑ever, is still unavailable.
11p
vialfrednobel
23-12-2023
2
2
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Cancer of Unknown Primary (CUP) is metastatic cancer with an unidentifiable primary tumour origin during life. It remains difficult to study the occurrence and aetiology of CUP. Hitherto, it is unclear whether risk factors are associated with CUP, yet identifying these factors could reveal whether CUP is a specific entity or a cluster of metastasised cancers from various primary tumour origins.
13p
vischultz
20-10-2023
6
1
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Giant breast malignant phyllodes tumor or sarcoma (GBPS) are rare entities with diameter larger than 10 cm and variously histological pleomorphisms. This disease poses a significant threat to the quality of life of individuals, and its prognosis remains unclear. This study aimed to explore the diferential diagnosis, treatment, and prognosis of GBPS in a real-world retrospective cohort.
14p
vioracle
29-09-2023
3
2
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Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in multiple organs with lungs being the most commonly involved. Gastrointestinal sarcoidosis is a rare entity.
3p
viintuit
26-09-2023
2
0
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Accurate extraction of breast cancer patients’ phenotypes is important for clinical decision support and clinical research. This study developed and evaluated cancer domain pretrained CancerBERT models for extracting breast cancer phenotypes from clinical texts.
9p
vighostrider
25-05-2023
2
2
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Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer entities, including prostate cancer (PCa). Sectioning and haematoxylin and eosin (H&E) staining technique remain the gold standard for the evaluation of LN metastases despite some limitations, especially low sensitivity in detecting an accurate tumour burden within the LN, as well as a subjective and time-consuming result.
10p
vikolindagrabar
27-07-2022
10
2
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Cancer is an extremely complex disease. Recent largescale studies have revealed fascinating insights into the genetic make-up of multiple tumor entities, but numerous challenges remain.
4p
vialfrednobel
29-01-2022
15
0
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Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor entities and often associated with a favorable outcome. The aim of this study was to evaluate the infiltration of immune cells in gliomas and their association with cerebrospinal fluid (CSF) cytokine concentrations.
13p
vimahuateng
26-11-2021
13
1
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Small soft tissue masses are often falsely assumed to be benign and resected with failure to achieve tumor-free margins. Therefore, this study retrospectively investigated the distribution of histopathologic diagnosis to be encountered in small soft tissue tumors (≤ 5 cm) in a large series of a tertiary referral center.
10p
vianrose2711
27-04-2021
13
0
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Immune checkpoint inhibitors (ICI) have become standard treatment in different tumor entities. However, safe treatment with ICI targeting the PD-1/PD-L1 axis requires early detection of immune-related adverse events (irAE).
10p
vianrose2711
27-04-2021
12
2
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Recently it has been revealed that lung adenocarcinomas with distinct gene mutations or fusions are associated with particular histopathological entities. For example, epidermal growth factor receptor (EGFR) gene mutations are often associated with well differentiated adenocarcinoma of the lung with bronchioloalveolar pattern.
4p
vimontana2711
05-04-2021
8
2
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The Cancer Genome Atlas (TCGA) is a pool of molecular data sets publicly accessible and freely available to cancer researchers anywhere around the world. However, wide spread use is limited since an advanced knowledge of statistics and statistical software is required.
7p
vioklahoma2711
19-11-2020
9
2
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Clear cell sarcoma (CCS) and malignant melanoma share overlapping immunohistochemistry with regard to the melanocytic markers HMB45, S100, and Melan-A. However, the translocation t(12; 22)(q13; q12) is specific to CCS. Therefore, although these neoplasms are closely related, they are now considered to be distinct entities.
4p
vijisoo2711
30-09-2020
9
1
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Cancer, far more than any other disease entity, requires a multidisciplinary approach. This multidisciplinary approach to cancer involves the integration of treatment strategies specifically set forth by surgical oncologists, medical oncologists, and radiation oncologists.
2p
vijennie2711
29-09-2020
14
0
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Exercise seems to minimize prostate cancer specific mortality risk and treatment related side effects like fatigue and incontinence. However the influence of physical activity on the immunological level remains uncertain. Even prostate cancer patients undergoing palliative treatment often have a relatively long life span compared to other cancer entities.
6p
vijennie2711
29-09-2020
13
1
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In the present study we determined the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.
19p
virose2711
25-09-2020
17
0
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