Candidate drugs

This plant contains natural compounds such as iridoids, naphthalene glycosides, and especially anthraquinones and anthraquinone glycosides. [9,10] Several compositions of M. longissima stems and roots have been reported to inhibit the in vitro replication of the hepatitis B virus. [11,12] Thus, the search for TNF-α inhibitors from the M. longissima plant and their natural constituents, especially anthraquinone compounds, by molecular docking approaches is necessary for the discovery of potential drug candidates for inflammation-mediated diseases.

7p dianmotminh02 03-05-2024 5 1   Download

Ebook "Synthesis of heterocycles in contemporary medicinal chemistry" is special in several aspects. First, it was composed by industrial medicinal and process chemists with decades of industrial experience. Secondly, it is dedicated to the heterocyclic drug compounds that have particularly marked the area of medicinal chemistry over the last decade.

281p tracanhphuonghoa1007 22-04-2024 7 3   Download

Ebook "Reducing drug attrition (Topics in Medicinal chemistry, Volume 11)" is to provide guidance to those persons who are dedicated to the creation and development of new drugs to aid patients. Our aim was to address the key factors that have led to failure of preclinical and clinical drug candidates. Despite the significant scientific advances over the past few decades in the disciplines associated with research and development (R&D), the overall productivity, as measured by new approved drugs, has not improved.

176p tudohanhtau1006 29-03-2024 1 1   Download

While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.

18p viellison 28-03-2024 1 1   Download

The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).

13p vicwell 29-02-2024 2 1   Download

Ebook "Fragment-based drug discovery and X-ray crystallography (Topics in current chemistry, Volume 317)" bring together chapters by a number of practitioners in the field, drawn from both the pharmaceutical industry and academia. Our aim has been to highlight the important roles that X-ray crystallography plays in the fragmentapproach: as a sensitive technique for primary screening, its use in combination with other biophysical techniques to allow robust hit validation, and its importance in providing structural information to guide progression from hit to clinical candidate.

235p manmanthanhla0201 26-02-2024 6 1   Download

Ebook "Medicinal chemistry and pharmacological potential of fullerenes and carbon nanotubes" particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.

411p manmanthanhla0201 27-02-2024 3 1   Download

Mesoporous silica nanoparticles (MSNs) have been demonstrated as a promising candidate in drug delivery applications. With the ambition of enhancing their drug loading capacity and controlled release, in this innovative study, MSNs were tailored with polyamidoamine (PAMAM) dendrimers thereby exerting advantageous properties onto the surface of the nanoplatforms.

7p vimichaelfaraday 28-12-2023 5 3   Download

Part 2 book "Comparative hepatitis" includes content: Comparative hepatitis - Diseases caused by adult parasites or their distinct life cycle stages, autoimmune hepatitis in humans, hepatitis in dogs, hepatitis in horses, the woodchuck model of hepadnavirus infection, hepadnaviruses have a narrow host range — do they, the liver as immune escape site for pathogens, drug candidates for the treatment of viral hepatitis.

219p muasambanhan01 13-12-2023 3 1   Download

Bladder cancer (BC) is one of the most common malignant diseases and the most common causes of cancer death worldwide. Immunotherapy has opened new avenues for precision treatment of bladder tumours, and immune checkpoint inhibitors (ICIs) have revolutionized the clinical treatment strategy of bladder tumours.

15p vischultz 20-10-2023 4 1   Download

Part 1 book "Antiparasitic and antibacterial drug discovery - From molecular targets to drug candidates" includes content: Anthelmintic resistance as a guide to the discovery of new drugs, target identification and validation in antiparasitic drug discovery, selective drug targets in parasites, lessons learned from target based lead discovery, approaches towards antiparasitic drug candidates for veterinary use,.... and other contents.

235p oursky04 14-09-2023 4 3   Download

Part 2 book "Antiparasitic and antibacterial drug discovery - From molecular targets to drug candidates" includes content: In search of trypanocidal drugs, trypanosomatid protein kinases as potential drug targets, chemotherapeutic development strategies for schistosomiasis, searching new antiparasitics in virtual space, chemical optimization of anthelmintic compounds – a case study,.... and other contents.

255p oursky04 14-09-2023 5 4   Download

GAW20 working group 5 brought together researchers who contributed 7 papers with the aim of evaluating methods to detect genetic by epigenetic interactions. GAW20 distributed real data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study, including single-nucleotide polymorphism (SNP) markers, methylation (cytosine-phosphate-guanine [CpG]) markers, and phenotype information on up to 995 individuals.

7p vihagrid 30-01-2023 5 3   Download

The aim of this work was to strengthen the evidence of using micro diatom frustule as a promising candidate for drug loading materials for both hydrophobic and hydrophilic drug models. The morphological, surface elemental composition of diatomite powder, a raw source of micro diatom frustules and purified diatomite to collect micro diatom frustule were investigated.

6p paddington36 04-01-2022 15 1   Download

Catecholamines are the first-line vasopressors used in patients with septic shock. However, the search for novel drug candidates is still of great importance due to the development of adrenergic hyposensitivity accompanied by a decrease in catecholamine activity. Terlipressin (TP) is a synthetic vasopressin analogue used in the management of patients with septic shock. In the current study, we aimed to compare the effects of TP and catecholamine infusion in treating septic shock patients.

8p vizhangzhidong 29-12-2021 7 0   Download

Biotinylated analogs of drug candidates provide useful tools for studying the drug–target protein interactions. Polyhalogenated N,N’diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N’-diarylureas were synthesized and evaluated in AMPK-activation studies.

7p langthannam 29-12-2021 9 0   Download

Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents.

9p langthannam 29-12-2021 10 1   Download

In the study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h.

12p langthannam 29-12-2021 14 0   Download

The adverse effects of high temperature stress can be alleviated by thermotolerance induced by exogenous application of plant growth regulators or by gradual application of temperature stress. Physalis peruviana L., commonly known as the Cape gooseberry, is a source of a variety of phytocompounds such as withanolides (withanone, withaferin A, and withanolide A). These withanolides are potentially high-value drug candidates because of their various pharmacological properties. The production of withanolides via traditional agriculture is commercially inadequate.

7p tudichquannguyet 29-11-2021 14 1   Download

Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a–g) were synthesized and characterized by elemental analysis, 1H NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a–g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (–H, –CH3, and –I) and their positions (ortho, meta, and para) on the antiproliferative activities were evaluated.

9p tudichquannguyet 29-11-2021 8 1   Download