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Cardiac toxicities
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Amiodarone is one of the most commonly used and effective antiarrhythmic drugs to treat ventricular and supraventricular arrhythmias. Besides its advantages, this drug has side effects like liver, digestive, pulmonary, thyroid, neural, skin, optical, hematologic, psychiatric, and cardiac complications.
4p
vitiki
30-01-2024
2
2
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Part 2 book "Modern medical toxicology" includes content: Cardiac drugs and lipid lowering agents, anticoagulants and related drugs, cardiotoxic plants, toxic gases, miscellaneous drugs and poisons, hydrocarbons and pesticides, gastrointestinal and endocrinal drugs, substances of dependence and abuse, . biochemical and haematological tests, analytical instrumentation, food poisoning.
317p
oursky02
06-08-2023
5
2
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The impact of pectoralis muscle mass index (PMI) on cardiac events is not well studied in cancer patients, especially in those who have received chemotherapy with high potential cardiac toxicity such as anthracyclines.
8p
vikolindagrabar
27-07-2022
6
2
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Epinephrine is a first-line drug for cardiopulmonary resuscitation, but its efficacy in the treatment of bupivacaine-induced cardiac toxicity is still in question. We hypothesized that epinephrine can reverse cardiac inhibition of bupivacaine by modulating ion flows through the ventricular myocyte membrane channels of rats.
8p
viisaacnewton
25-04-2022
10
1
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Clostridium difficile (CD) is the most common pathogen causing nosocomial diarrhea. The clinical presentation ranges from mild diarrhea to severe complications, including pseudomembranous colitis, toxic megacolon, sepsis, and multi-organ failure.
8p
vampires36
30-12-2021
15
1
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Today, cancer ranks as one of the leading causes of death. Despite the large number of novel available therapies, radiotherapy (RT) remains as the most effective non-surgical method to cure cancer patients. In fact, approximately 50% of all cancer patients receive some type of RT and among these 60% receive RT-treatment with a curative intent.
9p
vimahuateng
26-11-2021
10
1
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Carfilzomib is a selective proteasome inhibitor approved in the United States in 2012 for the treatment of relapsed and refractory multiple myeloma. Although cardiopulmonary and vascular events have been reported infrequently, they can be potentially serious complications, and their incidence and pathophysiology following carfilzomib treatment remain poorly characterized in a real-world patient population.
9p
vilisa271
22-09-2020
14
0
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Cancer is the leading cause of premature death in Canada. In the last decade, important gains in cancer survival have been achieved by advances in adjuvant treatment. However, many oncologic treatments also result in cardiovascular "toxicity".
6p
vimale2711
25-08-2020
13
1
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To assess the personal beliefs of radiation oncologists regarding heart sparing techniques in breast cancer patients. Most radiation oncologists believe that there is enough evidence to support heart sparing for breast cancer patients.
7p
vidhaka2711
31-07-2020
12
1
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Anthracycline-induced cardiac toxicity is a cause of significant morbidity and early mortality in survivors of childhood cancer. Current strategies for predicting which children are at greatest risk for toxicity are imperfect and diagnosis of cardiac injury is usually made relatively late in the natural history of the disease.
9p
vidhaka2711
31-07-2020
16
1
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Cancer treatment during pregnancy is a growing problem especially now that women delay childbearing. Systemic treatment of these malignancies during pregnancy centers mainly on the anticancer drugs anthracyclines, widely used in treating hematological and breast cancer during pregnancy and sometimes associated with early and late toxicity for the fetus.
9p
vimanama2711
30-07-2020
15
2
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Chemoradiotherapy effectively treats superficial esophageal cancer and is optimal to preserve organs. However, late toxicity, particularly in cardiac diseases, obstructs clinical outcomes. We revealed the risk factors for cardiac event development post-chemoradiotherapy.
7p
viputrajaya2711
22-06-2020
11
1
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The progress of treatments of childhood acute lymphoblastic leukemia (ALL) has made it possible to reach a survival rate superior to 80%. However, the treatments lead to several long-term adverse effects, including cardiac toxicity.
8p
vikuala271
13-06-2020
10
1
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Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs underscores the need for better, more predictive in vitro safety screens to be deployed early in the drug discovery process.
12p
vienzym2711
03-04-2020
11
3
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Drugs not commonly considered to be cardioactive agents may cause prolongation of the QT interval with resultant torsades de pointes and ventricular fibrillation. This form of drug toxicity often causes cardiac arrest or sudden death.
6p
vienzym2711
03-04-2020
14
2
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Gloriosa superba (GSb) is a highly poisonous plant and its toxicity is due to anti-mitotic effects of constituents such as colchicine and gloriosine on rapidly proliferating cells. Poisoning is known to cause very rapid and severe clinical manifestations due gastro intestinal, neurological, cardiac and bone marrow toxicity.
4p
vienzym2711
30-03-2020
16
2
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Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline.
12p
vimax2711
30-03-2020
23
2
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Cardiac glycosides are natural compounds used for the treatment of congestive heart failure and cardiac arrhythmias. Recently, they have been reported to exhibit anticancer activity. Proscillaridin A (PSN-A), a cardiac glycoside constituent of Urginea maritima has been shown to exhibit anticancer activity. However, the cellular targets and anticancer mechanism of PSN-A in various cancers including prostate cancer remain largely unexplored.
8p
vihasaki2711
12-11-2019
29
1
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(BQ) Continued part 1, part 2 of the document A simplified approach with Goldberger’s clinical electrocardiography has contents: Digitalis toxicity, limitations and uses of the ECG, sudden cardiac arrest and sudden cardiac death syndromes, pacemakers and implantable cardioverter defibrillators - essentials for clinicians,... and other contents. Invite you to refer.
181p
thuongdanguyetan05
05-07-2019
6
0
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Students conduct mechanistic and translational research on: the causes of breast, liver, lung and prostate cancer, inflammatory processes in cardiomyopathy, signal pathway disruption in cardiac hypertrophy, chronic obstructive pulmonary disease (COPD), autoimmunity, neurodevelopmental disorders and identification of pathways of toxicity. Seminars, journal clubs and research retreats are an integral part of the student experience.
44p
nhamnhiqa
01-03-2013
57
1
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