Careful annotation

High throughput sequencing technologies have been an increasingly critical aspect of precision medicine owing to a better identification of disease targets, which contributes to improved health care cost and clinical outcomes. In particular, disease-oriented targeted enrichment sequencing is becoming a widely-accepted application for diagnostic purposes, which can interrogate known diagnostic variants as well as identify novel biomarkers from panels of entire human coding exome or disease-associated genes.

11p vibeauty 23-10-2021 14 1   Download

The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated.

4p visilicon2711 20-08-2021 13 1   Download

Loss-of-function phenotypes are widely used to infer gene function using the principle that similar phenotypes are indicative of similar functions. However, converting phenotypic to functional annotations requires careful interpretation of phenotypic descriptions and assessment of phenotypic similarity.

12p vioklahoma2711 19-11-2020 10 1   Download

Automatically understanding chemical-disease relations (CDRs) is crucial in various areas of biomedical research and health care. Supervised machine learning provides a feasible solution to automatically extract relations between biomedical entities from scientific literature, its success, however, heavily depends on large-scale biomedical corpora manually annotated with intensive labor and tremendous investment.

14p vijisoo2711 27-10-2020 16 1   Download

Most ontologies are being developed in an engineering-oriented method: A small group of engineers carefully builds and maintains a presentation of their view of the world. Certainly, there are several tools oriented towards collaborative work: A consensus-building mechanism that allows a large group of people to contribute or annotate a common ontology in a collaborative way to reach consensus among individuals.

12p vititan2711 13-08-2019 16 1   Download

This paper presents ongoing research in clinical information extraction. This work introduces a new genre of text which are not well-written, noise prone, ungrammatical and with much cryptic content. A corpus of clinical progress notes drawn form an Intensive Care Service has been manually annotated with more than 15000 clinical named entities in 11 entity types. This paper reports on the challenges involved in creating the annotation schema, and recognising and annotating clinical named entities. ...

9p hongphan_1 15-04-2013 42 2   Download

Together, Flex and Java make a powerful web development platform—they blend the strengths of Java on the server with the richness of Flex on the frontend. Flex on Java is a unique book that teaches you how to work with Flex in concert with the full array of Java technologies: Spring, POJOs, JMS, and other standard tools. You also learn how to integrate Flex with server-side Java via BlazeDS remoting. Almost all the carefully annotated examples use free or open source software.

262p phungnguyet_123 20-02-2013 58 10   Download

Discovering the distinction between Roles (local restrictions on properties), and Properties (annotations to a specific class) was another important step. At this point in the development, we were forced to make a choice in which species of OWL to use. Developers attached properties that are not inherited to concepts. If the translator directly attached Properties to classes, the ontology would be in OWL Full. For computational benefits, we decided to work in OWL Lite, and thus owl:AnnotationProperties were used. For other conversions, these...

15p taisaokhongthedung 09-01-2013 68 2   Download

This is paper are the more or less raw results of the trial and error natural process of hacking a system. As the initial idea was not to made it public, I did not take care of the “feel and look” and I wrote as a simple reminder to me of what attack vectors where tried and its time-line. As the R+D work increased, what where simple annotations begun to look interesting, maybe for readers other than me. At the end I got what I was looking for: a way to hack the tested system, but then I realize that what was more interesting –at...

219p hidiefei 17-05-2012 76 15   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The SeqFEATURE library of 3D functional site models: comparison to existing methods and applications to protein function annotation...

19p coxanh_8 05-11-2011 56 1   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation...

12p coxanh_8 05-11-2011 47 1   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species...

23p coxanh_8 05-11-2011 53 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly...

12p thulanh19 05-11-2011 45 1   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data...

9p thulanh19 05-11-2011 41 1   Download