Cases of neonatal sepsis

The first case presented at Neonatal Intensive Care Unit with an 18-hour-history of irritability, vomiting, and abdominal distension. With high white blood cell count and C-reactive protein level, the baby was initially diagnosed with neonatal sepsis. The ultrasound performed on day 3 after hospitalization found peritonitis but not seen appendicitis.

6p inception36 30-11-2021 10 1   Download

Neonatal septicemia is a clinically diagnosed condition having diverse etiology and changing antibiotic sensitivity pattern. The knowledge of common bacterial agents causing septicemia and their antibiogram is useful in deciding empirical antimicrobial therapy. The neonatal blood cultures were studied to know the bacterial species and their antibiotic sensitivity pattern. Aim of the study is to evaluate sensitivity pattern of bacterial isolates causing neonatal septicemia and to know clinical outcome of the cases.

9p angicungduoc6 20-07-2020 13 1   Download

Neonatal septicemia is responsible for nearly half of neonatal deaths. With emerging drug resistance mechanisms like Metallo Beta lactamase (MBL) production, treatment of neonatal sepsis has become a challenge. The present study was done to identify prevalence of bacterial pathogens, their resistance profile and incidence of MBL mediated resistance among Gram negative bacterial isolates in neonatal sepsis. Seventy three cases of suspected neonatal septicemia were included in this prospective study. Blood culture was done by BacT/Alert 3D system, bacterial isolates were identified.

7p angicungduoc6 20-07-2020 10 1   Download

Lactic acidosis is a common finding in neonates, in whom mitochondrial dysfunction is often secondary to tissue hypoperfusion, respiratory failure, and/or sepsis. Primary (non-physiological) lactic acidosis is comparatively rare, and suggests the presence of an inborn error of mitochondrial energy metabolism.

4p viorochimaru2711 29-05-2020 12 0   Download

Oxidase positive, non-fermenting, Gram negative bacilli are invariably incorrectly identified as Pseudomonas species in conventional culture methods often missing out isolates of Ochrobactrum anthropi. We report here the clinical and microbiological characteristics of this rare pathogen from a case of neonatal sepsis. Rapid isolation and correct identification followed by appropriate antimicrobial therapy was the key to favourable clinical outcome.

4p angicungduoc4 26-04-2020 19 2   Download

C-reactive protein (CRP) is widely used to detect bacterial infection in children. We investigated the impact of CRP test results on decision-making and summarized the evidence base (EB) of CRP testing.

7p virubber2711 21-03-2020 13 0   Download

Neonatal sepsis is one of the significant reasons for morbidity and mortality among the neonates in the developing countries. To determine the bacterial isolates and their antibiotic susceptibility pattern. Blood cultures were performed for all clinically suspected neonatal septicemia cases for 1 year. Identification of all pathogenic isolates was done by conventional methods followed by antibiotic sensitivity testing by Kirby bauer disk diffusion method. A total of 225 suspected for neonatal septicemia were included in this study. Among this 78(34.

6p nguathienthan3 27-02-2020 26 0   Download

Single CRP in combination with RNSOS can be used for rapid identification of neonates with sepsis due to high sensitivity (95.6%) but cannot exclude those without sepsis due to low specificity (56.4%). Serial CRP done 12hrs apart can be used to exclude non-cases. This study demonstrated very high levels of resistance to the first-line antibiotics.

7p vichengshin2711 26-02-2020 17 1   Download

The main causative pathogens of NS in our hospital were Gram-positive cocci, among which coagulase-negative Staphylococcus spp such as S. epidermidis and S. haemolyticus were the main conditional pathogens; among Gram-negative pathogens, Klebsiella pneumoniae were most frequently isolated and showed widespread resistance to penicillins and cephalosporins.

6p videshiki2711 19-02-2020 14 0   Download

Reducing death due to neonatal sepsis is a global health priority, however there are limited tools to facilitate early recognition and treatment. We hypothesized that measuring circulating biomarkers of endothelial function and integrity (i.e. Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome.

12p vidr2711 19-02-2020 13 1   Download

Neonatal sepsis is a significant cause of morbidity and mortality in newborns and is responsible for 30 – 50 % of total neonatal deaths. Multidrug resistant Gram negative bacilli belonging to the family Enterobcteriaceae have been increasingly responsible for infections among the neonates admitted to the NICU in many countries including India. The study was conducted to know prevalence of ESBL production in Klebsiella pneumoniae and Escherichia coli in NICU so that we can help clinicians to avoid injudicious use of antibiotics.

6p quenchua2 18-12-2019 12 1   Download

Neonatal septicemia constitutes a significant cause of neonatal mortality & morbidity in developing countries. It becomes essential to diagnose it as early as possible to reduce the mortality and treat with appropriate antibiotics. CRP is a sensitive & good inflammatory marker. Definite diagnosis of septicemia depends on positive blood culture, which takes around 48-72 hrs. Result of CRP test is available within an hour in tertiary care centers and remote areas, where there is no availability of well equipped laboratory setup for blood culture.

7p kethamoi2 15-12-2019 13 1   Download

The diagnosis of neonatal sepsis is difficult because clinical manifestation is non-specific. Timely detection and treatment will help in decreasing mortality and morbidity. Blood culture is gold standard but the diagnosis is often retrospective. Thus there is a need for an alternative method which is more rapid, reliable and sensitive. This study was designed to determine the sensitivity, specificity, NPV, PPV and accuracy of hs-CRP, IL-6 and PCT levels, as a diagnostic marker of EONS. 206 neonates with sign and symptoms of sepsis admitted in NICU were included in this study.

8p kethamoi2 14-12-2019 45 2   Download

Candida species are a common cause of neonatal nosocomial bloodstream infections in infants and are a leading cause of infectious-related mortality in the neonatal intensive care unit (NICU). The objective of this study was to determine the predominant organisms, antifungal sensitivity patterns and clinical risk factors in neonatal fungal blood stream infection cases (BSI) admitted to our hospital. This is a retrospective study of all neonatal fungal BSI cases between May 2018 and October 2018. Fungal sepsis was found in 25/210 (11.9%) of cases.

7p nguaconbaynhay1 08-12-2019 16 1   Download

Neonatal sepsis still remains a significant cause of morbidity and mortality in the newborn, particularly in preterm, low birth weight infants. Despite advances in neonatal care, overall case-fatality rates from sepsis may be as high as 50%. Clinical signs of bacterial infection are vague and non-specific, and up to now there exists no easily available, reliable marker of infection despite a large bulk of studies focussing on inflammatory indices in neonatology. Every neonatologist is faced with the uncertainty of under- or over- diagnosing bacterial infection.

104p bunmang_1 03-05-2013 64 8   Download