Cbl family
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Interleukin 2 (IL-2) influences the development and severity of pain due to its antinociceptive and immunomodulatory effects. Its production is influenced by the increased expression of c-Cbl (Casitas B-lineage lymphoma proto-oncogene) and Cbl-b E3 ubiquitin ligases. We evaluated the effects on IL-2-mediated changes in c-Cbl and Cbl-b expression in a rat model of chronic neuropathic pain.
9p vampires36 30-12-2021 16 0 Download
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Plants evolved from long-term adaptation to form regulatory mechanisms of perception, transduction, and response to stresses. The CBL–CIPK signaling system is a basic calcium sensor that plays an important role in sensing adverse environmental stimuli. CBLs can perceive and bind Ca2+ under adversity and then specifically interact with CIPKs. The activated CBL–CIPK complex phosphorylates downstream target proteins (such as ion channels and transporters), or regulates transcription factors and stress responsive genes.
10p tudichquannguyet 29-11-2021 8 1 Download
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The CBL-interacting protein kinase (CIPK) gene family plays important roles in plant growth, development, and responses to abiotic stresses. To date, the CIPKs have been extensively identified and characterized in various plants. However, there have been few studies on CIPKs in Dimocarpus longan Lour (D. longan). In this study we identified eight putative CIPKs in D. longan (DlCIPKs) according to RNA-seq data.
13p tudichquannguyet 29-11-2021 5 1 Download
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Calcineurin B-like proteins (CBLs) are major Ca2+ sensors that interact with CBL-interacting protein kinases (CIPKs) to regulate growth and development in plants. The CBL-CIPK network is involved in stress response, yet little is understood on how CBL-CIPK function in pepper (Capsicum annuum L.), a staple vegetable crop that is threatened by biotic and abiotic stressors.
18p visilicon2711 20-08-2021 10 1 Download
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Calcineurin B-like protein (CBL)-interacting protein kinases (CIPKs) are the primary components of calcium sensors, and play crucial roles in plant developmental processes, hormone signaling transduction, and in the response to exogenous stresses.
20p vilichoo2711 25-06-2021 12 1 Download
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Calcium ions, the most versatile secondary messenger found in plants, are involved in the regulation of diverse arrays of plant growth and development, as well as biotic and abiotic stress responses. The calcineurin B-like proteins are one of the most important genes that act as calcium sensors.
15p vihashirama2711 21-05-2020 16 1 Download
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In recent years a slow-type anion channel (SLAC) family composing five members, including slow anion channel associated 1 (SLAC1) and four SLAC1 homologs (SLAHs), has been identified in Arabidopsis thaliana.
12p caplock2711 21-02-2019 14 1 Download
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The regulator of ubiquitous kinase (Ruk) protein, also known as CIN85 or SETA, is an adaptor-type protein belonging to the CD2AP/CMS family. It was found in complexes with many signaling proteins, including phos1 phoinositol (PtdIns) 3-kinase (EC 2.7.1.137), Cbl, GRB2, p130Cas and Crk. Functional analysis of these interactions, implicated Ruk in the regulation of apoptosis, receptor endocytosis and cytoskeletal rearrangements.
7p research12 01-06-2013 26 3 Download