CD133+ cancer stem cells
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Ebook "Prominin-1 (CD133): New insights on stem & cancer stem cell biology" was conceived to celebrate the fi fteenth anniversary of the discovery of prominin-1, also known in the medical fi eld as CD133. This book is composed of 15 chapters that will describe, on one hand, the molecular and cellular biology of prominin-1 and other members of the prominin family and, on the other hand, the importance of this molecule in the medical fi eld as a valuable marker of stem and cancer stem cells.
255p tracanhphuonghoa1007 22-04-2024 7 1 Download
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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the adoptive immunotherapy of which is worth studying. CD133, a kind of cancer stem cell (CSC) antigen, together with glypican-3 (GPC3) has been proved to be highly expressed in HCC cells and both of them are used as targets to generate chimeric antigen receptor (CAR) T cells.
18p vikolindagrabar 27-07-2022 1 1 Download
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Fluorescence microscopy showed strong luminescent signals from ET2-exposed NTERA-2 cells. It was also demonstrated that the ET2 nanocomplex effectively labeled up to 97.74% of the tested NTERA2 cells, but only 2.35% of CCD-18Co human colon normal cells. Therefore, these results show that the ET2 luminescent nanocomplex specifically targeted and labeled CSCs, and may be used for further applications in fundamental and clinical research.
6p spiritedaway36 28-11-2021 6 1 Download
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This research is focused on using a rare-earth element, which is the fluorescent Tb3+ nano-ion, and the CD133 monoclonal antibody to create a CSC-targeting nanocomplex (LV3). Tb3+ nanorods were silica-surface treated and -NH2 activated before being conjugated with the monoclonal antibody (mAb) against CD133, a typical CSC surface marker...
7p nat_qb73 21-02-2021 7 1 Download
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Ovarian cancer is one of the most common cancers in women. Due to the difficulty in early detection and treatment of ovarian cancer, many research studies and clinical trials have been developed to discover more efficient therapies. Besides Western medicine, traditional medicine has gained increased interest as a research field with potential to lead to the production of marketable therapeutic products. With the diversity of tropical plants in Asia, traditional medicine has been very popular and has served as a traditional therapy for generations.
6p trinhthamhodang9 10-12-2020 21 2 Download
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Recently reported data have suggested that only a small subset of cancer cells possess the capability to initiate malignancies. These observations were based on investigation of cells within the primary tumors displaying a distinct surface marker pattern. CD133 marker is a putative hematopoietic and neuronal stem cell marker, which is also considered to be a tumorigenic marker in brain, prostate and liver. Recent studies have shown that a small population of CD133-positive cells, indeed, exists in human hepatocellular carcinoma (HCC) cell lines and primary HCC tissues.
11p trinhthamhodang9 10-12-2020 24 1 Download
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CD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinical and prognostic significance of CD133 in CRC remains controversial. Methods: Publications were identified which assessed the clinical or prognostic significance of CD133 in CRC up to October 2012. A meta-analysis was performed to clarify the association between CD133 expression and clinical outcomes.
6p vijisoo2711 30-09-2020 10 1 Download
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Cancer stem cells (CSCs) are notorious for their capacity of tumor progression, metastasis or resistance to chemo-radiotherapy. However, the undisputed role of cancer stem marker, CD133, in colorectal cancers (CRCs) is not clear yet.
10p vijisoo2711 29-09-2020 7 1 Download
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To characterize prognostic and risk factors of central nervous system (CNS) metastases in patients with epithelial ovarian cancer (EOC). Methods: A retrospective analysis of Xijing Hospital electronic medical records was conducted to identify patients with pathologically confirmed EOC and CNS metastases.
12p vilisa271 22-09-2020 9 1 Download
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Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133+ CSCs have been reported to resist conventional chemo- and radiotherapy, but little is known about their response to immune surveillance.
11p vinaypyidaw2711 26-08-2020 6 1 Download
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The heterogeneity and tumourigenicity of metastatic melanoma is attributed to a cancer stem cell model, with CD133 considered to be a cancer stem cell marker in melanoma as well as other tumours, but its role has remained controversial.
11p vimale2711 25-08-2020 7 2 Download
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The polyether antibiotic Salinomycin (Sal) is regarded as an inhibitor of cancer stem cells. Its effectiveness on human colorectal cancer (CRC) cells in vitro has been demonstrated before. The aim of this study was to establish a murine model to investigate the effectiveness of Sal in vivo. Furthermore, we investigated the impact of Sal on Wnt/β-catenin signaling in human CD133+ CRC cells.
15p vimale2711 25-08-2020 6 2 Download
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Tumour stem cells are considered important to promote disease progression, recurrence and treatment resistance following chemotherapy in colon cancer. However, genomic analyses of colorectal cancer have mainly been performed on integrated tumour tissue consisting of several different cell types in addition to differentiated tumour cells.
10p vimale2711 21-08-2020 10 4 Download
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CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these discussions.
9p vidhaka2711 31-07-2020 12 2 Download
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Retinoblastoma (Rb), the most common childhood intraocular malignant tumor, is reported to have cancer stem cells (CSCs) similar to other tumors. Our previous investigation in primary tumors identified the small sized cells with low CD133 (Prominin-1) and high CD44 (Hyaluronic acid receptor) expression to be putative Rb CSCs using flow cytometry (FSClo/SSClo/CD133lo/CD44hi)
12p vimanama2711 30-07-2020 11 2 Download
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The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate with breast tumor aggressiveness, suggesting that simultaneous targeting of the two surface antigens may be beneficial in treatment of TNBC.
11p vimanama2711 30-07-2020 9 1 Download
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Cervical cancer is a major cause of cancer-related mortality in women in the developing world. Cancer Stem cells (CSC) have been implicated in treatment resistance and metastases development; hence understanding their significance is important.
12p vibaku2711 22-07-2020 12 2 Download
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Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition.
10p vibaku2711 22-07-2020 13 1 Download
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Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel cancer stem cell marker for indicating tumour progression.
17p vimanila2711 25-06-2020 11 0 Download
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The CD133 transmembrane protein is a well-recognized stem cell marker that has been used to isolate putative cancer stem cell populations from gastric cancers (GCs). However, the molecular features or biomarkers underlying CD133 are largely unknown in GCs.
13p viputrajaya2711 22-06-2020 14 1 Download