Cecal ligation

Some studies have demonstrated dexmedetomidine has anti-inflammatory effect on septic rats. However, the mechanism of how dexmedetomidine exerts these effects is still remained unknown. This study was designed to investigate the mechanism of how dexmedetomidine inhibits the production of inflammatory mediators in cecal ligation and puncturinduced septic rats.

6p viisaacnewton 25-04-2022 7 1   Download

The present study investigated the phytochemical, antibacterial, acute toxicity properties, hemodynamic parameters, and myeloperoxidase activity of methanolic extract of Bauhinia vahlii (Bv), and its effects on cecal ligation and puncture (CLP)-induced sepsis in mice.

9p vimississippi2711 08-12-2020 5 1   Download

The present study aimed to determine the role of Kupffer cells (KCs) in cytochrome P450 (CYP) isozyme activity and the expression of its gene during polymicrobial sepsis. For ablation of KCs, rats were pretreated with gadolinium chloride (GdCl3 ) at 48 and 24 h before cecal ligation and punc-ture (CLP). The depletion of KCs was confirmed by measuring the mRNA level of the KC marker gene CD163.

11p cosis54 05-01-2013 40 2   Download