Cell activation

Astaxanthin (AST) and pycnogenol (PYC) are natural bioactive compounds commonly used in pharmaceuticals and functional foods due to their highly antioxidant activity and potential health benefits. However, the widespread application of astaxanthin is hindered by its poor water solubility and highly unsaturated structure. In this study, nanoparticles co-delivering astaxanthin and pycnogenol (NAP) were fabricated to enhance the dispersibility, stability, and bioavailability of astaxanthin.

9p vifilm 11-10-2024 1 0   Download

A novel series of s-triazine derivatives was designed and screened for in silico an cancer activity in histone deacetylase 6 (HDAC6) target by molecular docking method using AutoDock Vina.

10p vifilm 11-10-2024 1 0   Download

FtsZ is conserved in almost all bacteria and is an essential protein for bacterial cell division. The cell division is prevented by the inhibitors against FtsZ’s functions. Thus, FtsZ is known as an attractive, and underexploited novel antibacterial target protein. The aim of this research is searching for new antibacterial agents from 72 plants collected in Central Vietnam.

6p vifaye 20-09-2024 3 1   Download

Green tea consumption has been shown to exhibit cancer-preventive activities in preclinical studies. Polyphenon E (Poly E) is a green tea standardized extract. This study was undertaken to examine the antiproliferative effect and pro-oxidant activity of Poly E on PC3 prostate cancer cells.

5p vifaye 20-09-2024 1 1   Download

The methanol extracts as well as some compounds from this plant exhibited anti-inflammatory, antimicrobial activity, antioxidant, hepatoprotective and anti-cancer effect, and antiosteoporotic. On going to search for bioactive components from the Vietnamese plant, this paper reported the isolation of seven phenolic compounds including one new from the aerial parts of A. ilicifolius. The cytotoxic activity of the isolates against two cancer cell lines (HepG2 and SK-LU1) were also screened and reported herein.

5p dianmotminh02 03-05-2024 8 2   Download

. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.

10p dianmotminh02 03-05-2024 6 3   Download

The specific objectives of this study are: 1. To conduct a literature review on carbon-based hydrogen storage electrodes and direct proton absorbance in various forms of carbon; 2. To prepare and characterise activated carbon samples with proper porosity for the present application; 3. To manufacture and characterise a range of composite materials containing carbon material and a proton-conducting medium such as nafion in various levels of hydration 4. To fabricate a number of membrane-electrode-assembly (MEA) from the composite materials;…

264p runthenight05 01-03-2023 6 3   Download

This thesis documents a research program in which Australian grown Danshen extracts and related bioactive compounds have been demonstrated to be effective in scavenging free radicals, namely ROS generation, in a cell free system and NADPH oxidase derived superoxide (O2-) generation in vascular tissue (rat aorta). Danshen extracts, both aqueous and ethanol, and their active compounds (Tanshinone IIA, Salvianolic Acid B and Danshensu) demonstrated anti-oxidant activity however findings exhibited stronger activity in a cell free system than in the aortic vascular tissue.

138p runthenight07 01-03-2023 9 3   Download

The primary objectives of this study were to: Investigate the fouling potential, and characterise the organic components of the membrane foulant layers, of clarified activated sludge and lagoon effluent obtained from the WTP; Investigate the fouling propensities of EOM and AOM derived from a blue-green algal culture as it passed through the growth cycle, ie., for which the cells had not been subject to physical disruption; Determine any difference in the fouling propensity of EOM and AOM and relate it to organic composition.

99p runthenight07 01-03-2023 3 3   Download

Recent sequencing technologies enable joint quantification of promoters and their enhancer regions, allowing inference of enhancer–promoter links. We show that current enhancer–promoter inference methods produce a high rate of false positive links. We introduce FOCS, a new inference method, and by benchmarking against ChIAPET, HiChIP, and eQTL data show that it results in lower false discovery rates and at the same time higher inference power.

14p vimichaelfaraday 25-03-2022 14 1   Download

The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infltration in breast cancer (BRCA) remain uncertain.

20p vielonmusk 21-01-2022 12 0   Download

Loss of prostate cancer differentiation or de-differentiation leads to an untreatable disease. Patient survival would benefit if this can be prevented or reversed. Cancer de-differentiation transforms luminal-like (differentiated) adenocarcinoma into less luminal-like and more stem-like (undifferentiated) small cell carcinoma through a sequential activation of stem cell transcription factors (scTF) POU5F1, LIN28A, SOX2 and NANOG.

13p vielonmusk 21-01-2022 11 0   Download

Malignant melanoma is an aggressive skin cancer and a tumor of melanocytic origin. Recent studies have suggested that long non-coding RNAs (lncRNAs) play crucial regulatory roles in multiple malignancies, including melanoma. Testis expressed 41 (TEX41) is a relatively new lncRNA whose mechanism in melanoma remains vague.

14p vielonmusk 21-01-2022 13 0   Download

PHI-101 is an orally available, selective checkpoint kinase 2 (Chk2) inhibitor. PHI-101 has shown antitumour activity in ovarian cancer cell lines and impaired DNA repair pathways in preclinical experiments. Furthermore, the in vivo study suggests the synergistic effect of PHI-101 through combination with PARP inhibitors for ovarian cancer treatment.

7p vielonmusk 21-01-2022 20 2   Download

Lactic acid produced by tumors has been shown to overcome immune surveillance, by suppressing the activation and function of T cells in the tumor microenvironment. The strategies employed to impair tumor cell glycolysis could improve immunosurveillance and tumor growth regulation. Dichloroacetate (DCA) limits the tumorderived lactic acid by altering the cancer cell metabolism.

12p vielonmusk 21-01-2022 7 0   Download

Peroxisomes are pivotal metabolic organelles that exist in almost all eukaryote cells. A reduction in numbers and enzymatic activities of peroxisomes was found in colon adenocarcinomas. However, the role of peroxisomes or the peroxisome pathway in colorectal cancer (CRC) is not defined.

17p vielonmusk 21-01-2022 12 0   Download

Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) has been implicated in multiple tumor type progression.

11p vielonmusk 21-01-2022 12 1   Download

The aim of our in vitro study was to assess the potential effect of BPF on H295R cells mitochondrial activity, metabolic activity, membrane integrity, lysosomal function, and testosterone synthesis. Adrenocortical carcinoma cells were cultivated during 24 h in the presence of BPF (0.1, 0.5, 1, 10, 25, 50, 75, 100, 300, 500 μM). Exposure doses of BPF caused a significant decrease of mitochondrial activity starting from 1 μM, we observed a slight increase in mitochondrial activity at the lowest concentration (0.1 μM).

4p mudbound 10-12-2021 13 1   Download

In vitro study evaluates the cytoroxicity, MTT assay, Inhibition of carbohydrates digestive enzymes and Glucose Uptake assay on Grewia umbellifera and Aphanamixis polystachaya. It shows that ELEGU has Glucose uptake by L6 cell lines to some extent than ELEAP.

253p spiritedaway36 26-11-2021 13 3   Download

Regulatory B cells (Bregs) produce antiinflammatory cytokines and inhibits proinflammatory response. Recently, immunosuppressive roles of Bregs in the effector functions of dendritic cells (DCs) were demonstrated. However, cross talk between Bregs and DCs in Helicobacter infection remains unknown. Here, we showed that direct stimulation of bone marrow-derived DCs (BMDCs) with Helicobacter felis (H.

11p thiencuuchu 27-11-2021 10 2   Download