Cell biology of the immune system

Ebook "Crossroads between innate and adaptive immunity IV (Advances in experimental medicine and biology, Volume 785)" presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.

144p duongthandue0501 28-02-2024 1 1   Download

The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular alterations.

22p vicwell 29-02-2024 5 2   Download

Ebook "Innate immunity of plants, animals, and humans (Nucleic acids and molecular biology, Volume 21)" wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.

248p tachieuhoa 28-01-2024 3 2   Download

Part 2 book "Encyclopedia of immunobiology (Vol 5 - Physiology and immune system dysfunction)" includes content: The immunology of pancreas transplantation, animal models of transplantation, mesenchymal stem cells and regenerative medicine, allergic contact dermatitis - immune reactions in the skin, allergen immunotherapy, biologicals to treat allergy and asthma, the hygiene hypothesis of allergy and asthma,....and other contents.

379p oursky06 17-10-2023 3 2   Download

Radiotherapy (RT) is the standard of care for most advanced head and neck squamous cell carcinoma (HNSCC) and results in an unfavorable 5-year overall survival of 40%. Despite strong biological rationale, combining RT with immune checkpoint inhibitors does not result in a survival benefit.

8p visharma 20-10-2023 2 2   Download

Part 1 book "Pediatric allergy principles and practice" includes contents: Epidemiology of allergic diseases, natural history of allergic diseases and asthma, the genetics of allergic disease and asthma, regulation and biology of immunoglobulin E, inflammatory and effector cells cell migration, the developing immune system and allergy.

340p oursky01 17-07-2023 2 2   Download

Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin features genome-wide, including histone modifications and chromosome conformation, in bone marrow pro-B and pre-B cells from young and aged mice.

24p vigalileogalilei 27-02-2022 17 1   Download

Like many bacteria, Vibrio cholerae deploys a harpoon-like type VI secretion system (T6SS) to compete against other microbes in environmental and host settings. The T6SS punctures adjacent cells and delivers toxic effector proteins that are harmless to bacteria carrying cognate immunity factors.

14p vielonmusk 30-01-2022 11 0   Download

A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Our data highlight the importance of transcriptional and epigenetic variability for the key role of neutrophils as the first responders to inflammatory stimuli.

17p vialfrednobel 29-01-2022 11 0   Download

Understanding the interactions between tumor and the host immune system is critical to finding prognostic biomarkers, reducing drug resistance, and developing new therapies. Novel computational methods are needed to estimate tumor-infiltrating immune cells and understand tumor–immune interactions in cancers.

16p viaristotle 29-01-2022 10 0   Download

In order to become functionally competent but harmless mediators of the immune system, T cells undergo a strict educational program in the thymus, where they learn to discriminate between self and non-self. This educational program is, to a large extent, mediated by medullary thymic epithelial cells that have a unique capacity to express, and subsequently present, a large fraction of body antigens.

13p viaristotle 29-01-2022 5 0   Download

CD40 is an important tumor necrosis factor receptor (TNFR) family protein for the development of antitumor response against cancer cells, apart from its role in the regulation of the immune system as a costimulatory molecule. It is broadly expressed on the surface of immune cells and in diverse cancer types, including breast cancer. Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype.

9p thiencuuchu 27-11-2021 12 1   Download

Loss of STAT1 (Signal Transducer and Activator of Transcription-1) has been implicated in the pathobiology of a number of cancer types. Nonetheless, the biological and clinical significance of STAT1 in esophageal squamous cell carcinomas (ESCC) has not been comprehensively studied.

14p vilisa271 22-09-2020 8 1   Download

The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop. The aim of cancer vaccination is to activate the host immune system and some success has been observed particularly in the use of the BCG vaccine for bladder cancer as an immunostimulant.

10p vinaypyidaw2711 26-08-2020 6 1   Download

Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes chronic inflammation of the joints. Analysis of genetic variants offers promise for guiding treatment and improving outcomes in RA. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in several biological functions including immune response, cell survival and apoptosis.

7p vicaracas2711 27-11-2019 10 0   Download

Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility. The four double bonds of AA predispose it to oxygenation that leads to a plethora of metabolites of considerable importance for the proper function of the immune system, promotion of allergies and inflammation, resolving of inflammation, mood, and appetite.

10p trinhthamhodang1 14-11-2019 12 1   Download

It is time to shift the arachidonic acid (ARA) paradigm from a harm-generating molecule to its status of polyunsaturated fatty acid essential for normal health. ARA is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. Arachidonic acid is obtained from food or by desaturation and chain elongation of the plant-rich essential fatty acid, linoleic acid.

9p trinhthamhodang1 14-11-2019 21 0   Download

(BQ) Part 1 of the document Histology - Illustrated interactive Q&A has contents: Cell biology, epithelialt issue, connective tissue, cartilage and bone, blood and hematopoiesis, muscle tissue, nerve tissue, skin and epidermal appendages, immune system and lymphoid organs, cardiovascular system, respiratory system, oral cavity and associated glands. Invite you to refer.

176p thuongdanguyetan06 06-06-2019 18 1   Download

In recent years, cell adhesion and cell adhesion molecules have been shown to be important for many normal biological processes, including embryonic cell migration, immune system functions and wound healing. It has also been shown that they contribute to the pathogenesis of a large number of common human disorders, such as rheumatoid arthritis and tumor cell metastasis in cancer.

15p caplock2711 19-02-2019 22 1   Download

Upon completion of this lesson, the successful participant will be able to: Distinguish between innate and acquired immunity; name and describe four types of phagocytic cells; describe the inflammation response; distinguish between the following pairs of terms: antigens and antibodies; antigen and epitope; B lymphocytes and T lymphocytes;...

49p nomoney10 04-05-2017 29 3   Download